< BACK Patty de Groot Discusses Digital Biomarkers in Rheumatology Podcast Jan 10, 2025 Exploring the Future of Digital Biomarkers in Rheumatology Patty de Groot from Erasmus MC recently appeared on the Digital Rheumatology Network podcast on Spotify, where she shared her insights on the role of digital biomarkers in rheumatology care. In this engaging conversation, Patty discusses the potential of digital tools, including findings from the iPROLEPSIS project, to improve early diagnosis, personalise treatment, and enhance patient care. She also talks about the use of design-thinking approaches to optimise healthcare workflows and the challenges of integrating digital innovations in clinical practice. Listen to the full podcast episode to learn more about how digital biomarkers are transforming rheumatology care and the future of healthcare innovation. 🎧 Listen here 1/1 PREVIOUS NEXT

< BACK Season's Greetings from iPROLEPSIS Dec 21, 2023 Merry Christmas and Happy New Year! No updates and announcements, simply warmth, joy, health and peace from the iPROLEPSIS consortium to all our community! Thank you for being a part of our journey. merry (1).png merry (1).png 1/1 PREVIOUS NEXT

< BACK ChatGPT in Nutrition: Trends, Challenges and Future Directions Jun 27, 2024 Exploring the Role of AI in Shaping the Future of Personalised Nutrition Introducing our latest iPROLEPSIS publication, "ChatGPT in Nutrition: Trends, Challenges, and Future Directions" , presented at PETRA 2024. This study explores the evolving role of AI in personalized nutrition. Abstract: A healthy and balanced diet is of paramount importance to the physical and psychological well-being of an individual, since unhealthy dietary choices have been linked with the occurrence of non-communicable diseases. Recent technological advances has led to the development of large language models, such as ChatGPT that has been widely adopted as a convenient tool for creating meal plans and obtaining nutritional information. This work aims to provide a thorough review of the scientific work performed so far regarding the use of ChatGPT in the field of nutrition. In this survey, the advantages and limitations of ChatGPT in different aspects of nutrition are pinpointed, while the challenges from the use of ChatGPT in nutrition are identified and discussed. Future research directions are also proposed to assist researchers towards the development of more effective nutrition recommendation systems. Read the full publication: https://zenodo.org/records/13142880 ChatGPT in Nutrition .pdf Download PDF • 620KB 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS at IEEE-EMBS BSN 2025 Nov 6, 2025 Showcasing iPROLEPSIS at a leading international conference on body sensor research The IEEE-EMBS International Conference on Body Sensor Networks (IEEE-EMBS BSN 2025) took place in Los Angeles, USA, from 3–5 November 2025. The conference brings together researchers, clinicians, and industry representatives working on body sensor technologies and their applications in health and biomedical research. iPROLEPSIS was showcased at the event by project partner PLUX , which hosted a dedicated booth. The project was presented to an international audience, increasing its visibility within the body sensor and digital health research community. IEEE EMBS 2025 2.HEIC IEEE EMBS 2025 1.HEIC IEEE EMBS 2025 3.HEIC IEEE EMBS 2025 2.HEIC 1/3 PREVIOUS NEXT

< BACK Ongoing preparation for the iPROLEPSIS-PDPID study Mar 4, 2024 iPROLEPSIS-PDPID Study: Advancing Psoriatic Arthritis through Innovative Digital Biomarkers Patients with Psoriatic arthritis (PsA) experience difficulties in dealing with unpredictable disease activity, which can affect their quality of life. Developing a digital biomarker using a smartphone and smartwatch would allow for unobtrusive monitoring of the disease activity in these patients. Besides, understanding what factors trigger flare would allow for better disease control. The iPROLEPSIS-PDPID study is a multicentre observational cohort study that aims to develop an unobtrusive and affordable digital biomarker capable of detecting changes in disease activity, including flare, and to identify triggers of flare in patients with PsA. The study will be conducted in four countries: the Netherlands, the UK, Portugal and Greece. Ethical approval for initiating the iPROLEPSIS-PDPID study in the Netherlands and the UK has been granted. The OpenClinica platform will be used in the collection and storage of data for the iPROLEPSIS-PDPID study. Future steps include obtaining ethical approvals for Portugal and Greece as well as local approvals from centres participating in each country, and inclusion of patients from each participating country. The miPROLEPSIS phone app , currently under development, will be used in this study. The app will be installed on the patient smartphone and utilised as a data collector, which will be then used for algorithms development and training. The app will measure physical activity, the length of sleep, self-registered flare, and register daily pain, fatigue, sleep and morning stiffness. The Garmin smartwatch Vivoactive 5 device will be used to collect data on physical activity, heart rate, heart rate variability and sleep quality. The collected data from Garmin will be downloaded from the miPROLEPSIS app by Wellics software (developer in the project), which allows extracting, visualising and exporting collected both company-processed data, as well as raw data. 10.png 13.png 14.png 10.png 1/5 PREVIOUS NEXT

< BACK Federated Learning Aggregation based on Weight Distribution Analysis Oct 4, 2023 Enhancing Federated Learning: Leveraging Weight Distribution Analysis for Superior Aggregation Federated learning has recently been proposed as a solution to the problem of using private or sensitive data for training a central deep model, without exchanging the local data. In federated learning, local models are trained on the client side using the available data, while a server is responsible for aggregating the weights of these models into a global model. However, the traditional weight averaging approach does not take into consideration the importance of the different weights for the performance of a model. To this end, this work proposes a novel federated learning weight aggregation method that estimates the statistical distance of each client's parameters from the Gaussianity, and weighs the contribution of each client to the global model accordingly so that the most significant information is retained and enhanced. To create an accurate global model, a complex weighted averaging of the parameters of clients' models at the layer level is performed, considering as low quality the parameters following the Gaussian distribution. The proposed method can be employed to both convolutional and linear layers and it is based on the notion that parameters following a Gaussian distribution do not significantly affect the output of a model. Experiments with different network architectures and a comparison with a plethora of state-of-the-art approaches on three well-known image classification datasets demonstrate the superiority of the proposed method for federated learning weight aggregation. Read the full publication: https://www.researchgate.net/publication/374440973_Federated_Learning_Aggregation_based_on_Weight_Distribution_Analysis 1/1 PREVIOUS NEXT

< BACK World Psoriasis Day 2025: Advancing Prevention and Care Oct 29, 2025 On World Psoriasis Day, iPROLEPSIS highlights ongoing efforts to improve early detection, prevention, and digital support for people living with psoriasis and psoriatic arthritis October 29 marks World Psoriasis Day – a day dedicated to raising awareness of the impact psoriasis has on millions worldwide. For many, the condition goes beyond the skin: up to 30% develop psoriatic arthritis , an inflammatory disease that causes joint pain, stiffness, and fatigue, significantly affecting daily life. This year’s World Psoriasis Day video shares how iPROLEPSIS is working to advance psoriatic arthritis prevention and care. Through clinical studies, digital biomarkers, and co-created digital health tools, the project aims to support early detection , timely monitoring , and personalised care . The ongoing PDPID study is developing and validating predictive models for psoriatic arthritis progression, while the iPROLEPSIS digital ecosystem – including the miPROLEPSIS apps, miDashboard for professionals, and lifestyle interventions – is designed together with patients and clinicians to make technology more supportive of everyday care. Its tools – the miPROLEPSIS and miPROLEPSIS-Lite apps, the miDashboard for professionals, and lifestyle interventions such as serious games and personalised recommendations – are co-created with patients and healthcare providers to ensure they are practical, easy to use, and truly supportive of everyday care. On this World Psoriasis Day, iPROLEPSIS stands with everyone living with psoriasis and psoriatic arthritis. Together with clinical and research partners across Europe, the project continues to work toward earlier detection, prevention, and innovative digital solutions to improve lives. Watch the World Psoriasis Day 2025 video here: https://www.youtube.com/watch?v=FvbTCNH9vMY Screenshot 2025-10-29 083418.png Screenshot 2025-10-29 083418.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS 3rd Plenary Meeting Nov 30, 2023 iPROLEPSIS 3rd Plenary Meeting in Rotterdam: 12-13 December 2023 On 12-13 December 2023, iPROLEPSIS partners will meet in Rotterdam for the third plenary meeting. The agenda includes workshops on the PDPID study, digital biomarkers, technical ecosystem development, serious games co-creation, an External Advisory Board session, and more. Stay tuned for updates on our progress! iPROLEPSIS 3rd Plenary meeting (1).png iPROLEPSIS 3rd Plenary meeting (1).png 1/1 PREVIOUS NEXT

< BACK Seasons Greetings from iPROLEPSIS Dec 23, 2025 Happy holidays and best wishes for the year ahead! We wish you a warm and peaceful holiday season. May the coming year bring good health, positive moments, and new opportunities. Happy holidays! iPROLEPSIS iPROLEPSIS Happy Holidays.png iPROLEPSIS Happy Holidays.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS at Faculdade de Motricidade Humana PhD Seminar Dec 4, 2025 Lecture on recent findings shared with PhD students On 20 November 2025 , iPROLEPSIS was presented at Faculdade de Motricidade Humana (FMH) during the PhD seminar “Métodos de Investigação Avançada em Motricidade Humana”. Sofia Balula Dias spoke to more than 20 PhD students , presenting key findings from the project’s most recent publications and ongoing research on psoriatic arthritis. The session was an opportunity to share current scientific work and answer questions from the students. Slide1.JPG Slide2.JPG Slide8.JPG Slide1.JPG 1/8 PREVIOUS NEXT

< BACK Designing Exergames for Psoriatic Arthritis: The Spy and Zen Forest Paradigms Feb 4, 2026 New iPROLEPSIS publication presents the co-design of exergames to support physical activity and rehabilitation in psoriatic arthritis A new publication from the iPROLEPSIS project has been published in the proceedings of the 2025 IEEE International Conference on E-health Networking, Application & Services (HealthCom) . Psoriatic arthritis (PsA) is a rheumatic disease affecting the skin and joints and is commonly associated with stiffness, impaired mobility, and chronic pain. In addition to biological treatments, physiotherapy and exercise are often recommended to improve range of motion and physical function. However, low adherence, high costs, and limited engagement frequently reduce the effectiveness of these interventions. The paper presents the design of two exergames – The Spy and Zen Forest – developed as accessible digital tools to complement traditional rehabilitation approaches. Exergames embed therapeutic movements into game mechanics, supporting motivation and consistency in physical activity. Both games were co-designed with 29 experts , including patients with psoriatic arthritis, clinicians, researchers, and technical stakeholders, to ensure alignment with clinical goals, patient needs, and safe physical engagement. In The Spy , players complete physically engaging missions designed to stimulate dynamic body movement and support coordination, mobility, balance, strength, and flexibility. Zen Forest focuses on slow, calm stretching routines inspired by Pilates and Yoga, promoting flexibility, relaxation, and body awareness. Together, the exergames aim to support personalised activity routines and enable clinicians to monitor progress and recommend tailored interventions. Read the full publication: https://zenodo.org/records/18468928 iPROLEPSIS_Zen and Spy.png iPROLEPSIS_Zen and Spy.png 1/1 PREVIOUS NEXT

< BACK British Society for Rheumatology Annual Conference 2024 Apr 26, 2024 Dr. Laura Coates Addresses Psoriasis to Psoriatic Arthritis Transition British Society for Rheumatology Annual Conference, the UK’s leading rheumatology event, took place on 24-26 April 2024. Dr Laura Coates discussed preventing the transition of psoriasis to psoriatic arthritis, including the evidence so far and studies underway with iPROLEPSIS and HIPPOCRATES IMI . Laura Coates_BRC 2024.jfif Laura Coates_BRC 2024.jfif 1/1 PREVIOUS NEXT