5 okt 2026
New iPROLEPSIS publication presents the protocol for an international study combining clinical, biological, environmental and digital data to investigate PsA flares
A new peer-reviewed publication from the iPROLEPSIS project presents the protocol of the Psoriatic Arthritis Digital Phenotyping and Inflammation Drivers (PDPID) study, an international multicentre prospective cohort study focused on improving the monitoring and prediction of psoriatic arthritis (PsA) flares.
The study is being conducted across 30 sites in the Netherlands, United Kingdom, Portugal and Greece and follows participants with PsA for 12 months. Its main objectives are to develop and internally validate digital biomarkers capable of detecting disease flares and to develop machine-learning models for flare prediction.
The PDPID study brings together several types of information. Clinical assessments and patient-reported outcomes are combined with biological markers, including DNA, gut microbiome, cortisol and C-reactive protein, as well as environmental information such as weather and air pollution.
Digital data are collected through the miPROLEPSIS app and a smartwatch. These include smartphone and smartwatch sensor data, keystroke dynamics, screen time, physical activity, sleep and other wellness measures. Participants can also report flares through the app and complete questionnaires and photo- and video-based assessments.
By combining these different data sources, the study aims to identify patterns associated with changes in disease activity and investigate factors that may contribute to PsA flares. The resulting models are intended to support continuous and less burdensome monitoring of disease activity and, in the longer term, contribute to more personalised approaches to PsA management.
The study also incorporates patient involvement. People with PsA contributed to the development and testing of the app and continue to provide feedback on the study procedures, usability and user experience.
The article, “Psoriatic arthritis digital phenotyping and inflammation drivers (PDPID) study: protocol for an international multicentre prospective cohort”, was published in BMJ Open in September 2026.
Read the full open-access publication: https://doi.org/10.1136/bmjopen-2025-115903
