iPROLEPSIS networking activities

Sobre os parceiros do consórcio Coordenador do projeto iPROLEPSIS Coordination About team Software development About team Clinical experts About team Ethics, legal, exploitation About team Data sience About team Dissemination and communication About team

Sobre os parceiros do consórcio Kristina Leipuviene SmartSol SIA Position Project manager What is your role in iPROLEPSIS? Dissemination/Communication lead What are your main activities in the project? Leading and planning communication and dissemination activities. SmartSol team also supports networking and clustering with stakeholders. What is your motivation? As leaders of WP6, SmartSol aims to increase awareness of iPROLEPSIS and make it accessible to everyone. We focus on sharing information, raising awareness about psoriatic arthritis, and making a lasting impact through thoughtful planning and engagement with the public.

Sobre os parceiros do consórcio Laura Coates Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Position NIHR Research Professor What is your role in iPROLEPSIS? Lead for WP5 (clinical studies) What are your main activities in the project? I oversee all of the clinical studies within the consortium. What is your motivation? I am a rheumatologist who has worked in research in psoriatic arthritis for around 20 years. My interest is in improving outcomes for people living with psoriatic arthritis and I believe that work in this project can help us to predict, monitor and understand the disease better in day to day clinics.

The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalized digital care ecosystem. iPROLEPSIS é um solução para artrite psoriática O projeto iPROLEPSIS explica a inflamação da artrite psoriática através da análise de dados de múltiplas fontes, com orientação de um novo ecossistema de cuidados digitais personalizados. SOBRE o CONSÓRCIO CONTACTE-NOS outubro de 2025 Hoje segunda terça quarta quinta sexta sábado domingo 29 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Dia (1/4) HLTH Event 2025 Mais 1 20 Dia (2/4) HLTH Event 2025 Mais 1 21 Dia (3/4) HLTH Event 2025 Mais 1 Mais 2 22 Dia (4/4) HLTH Event 2025 Mais 1 23 24 25 26 27 28 29 30 31 1 2 3 4 5 6 7 8 9 Próximos eventos A artrite psoriática (PsA) é uma doença crónica progressiva inflamatória que afeta 1-2% da população geral, manifestando-se em até 30% das pessoas com psoríase (PsO). Visão do projeto e impacto iPROLEPSIS é um projeto financiado pelo Horizon Europe que desenvolve um novo ecossistema de atendimento digital personalizado para pessoas com PsA. O objetivo do iPROLEPSIS é propor um novo ecossistema que envolve mecanismos de recolha de Dados do Mundo Real (RWD) e um poderoso sistema de apoio à decisão para fornecer novos conhecimentos sobre os fatores chave que influenciam a transição da saúde para a artrite psoriática (PsA), adotando uma abordagem multiescala/multifatorial. Assim, com o uso de modelos baseados em xAI, oferecer um ecossistema de cuidados digitais personalizados eficiente, eficaz e clinicamente validado para pacientes com PsA. DESCUBRA MAIS Objetivos e atividades do projeto O consórcio iPROLEPSIS trabalha em 7 objetivos chave no campo da Artrite Psoriática (PsA) e tem 6 atividades que irão reunir diversas e complementares competências dos parceiros do consórcio. DESCUBRA MAIS Sobre o projeto 15 Parceiros 9 Países 48 M Duração do projeto 6,4 M € Total Investimento Os domínios de atividade central Estabelecimento • A base para as atividades de pesquisa do projeto é estabelecida por meio de uma exploração extensiva da literatura e dos dados disponíveis e do desenho dos estudos de recolha e validação de dados clínicos; • Será utilizado um design participativo que apoiará o desenvolvimento de um ecossistema de soluções orientado para o utilizador para estabelecer um quadro para a investigação e desenvolvimento (I&D) baseado em IA de confiança. Validação • A concepção e implementação de estudos clínicos que irão recolher dados de investigação, validar os biomarcadores digitais de sintomas inflamatórios em indivíduos em risco de pacientes com PsA e PSO e avaliar a eficácia das ferramentas de cuidados digitais no que diz respeito à prevenção da exacerbação da inflamação. Investigação e desenvolvimento • Pesquisa sobre dados multimodais para revelar os principais fatores de inflamação da PsA, fornecer biomarcadores digitais dos sintomas inflamatórios da PsA e explorar o efeito da PsA nas articulações e na microvasculatura da pele, bem como o papel das células mastro na transição da PsA; • Sintetizar os resultados num modelo multiescala/multifatorial da transição da saúde para PsA; • Fornecer o ecossistema de saúde digital iPROLEPSIS integrado, que inclui ferramentas para cuidados preventivos personalizados de PsA, para capacitar pacientes e profissionais de saúde. Contacte-nos Agradecemos os seus comentários ou questões sobre o projeto iPROLEPSIS! CONTACTE-NOS

iPROLEPSIS networking activities Our shared vision is to establish a robust ecosystem of initiatives , where the combined strength of each project contributes to the overarching goal of advancing healthcare and well-being . By pooling our resources, knowledge, and expertise, we believe in the potential for significant benefits both for the collaborative cluster and the individual projects involved. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Key Facts Key Facts Quizzes about Psoriatic Arthritis Take a Quiz Search about Psoriatic Arthritis Search Psoriatic Arthritis Handbook Handbook News Feed about Psoriatic Arthritis News Feed

Download needed deliverables for iProlepsis project for psoriatic arthritis. Entregáveis D1.2 Data managmeent plan (initial version) WP1 - Management and coordination Read More D2.3 The iPROLEPSIS trustworthy AI framework WP2 - Knowledge mining, foundation and participatory design Read More D6.1 Project branding and communication channels WP6 - Dissemination, communication and exploitation Read More D2.1 Initial report on user research and co-creation process WP2 - Knowledge mining, foundation and participatory design Read More D4.2 The iPROLEPSIS patient and HCP apps (study version) WP4 - Development of the iPROLEPSIS digital health ecosystem for personalised preventive care Read More D6.2 Dissemination, exploitation and communication plan WP6 - Dissemination, communication and exploitation Read More D2.2 Initial report on the state-of-the-art and datasets WP2 - Knowledge mining, foundation and participatory design Read More D5.1 Study initiation package (iPROLEPSIS-PDPID study) WP5 - Clinical studies Read More D6.3 First report on project visibility and educational material WP6 - Dissemination, communication and exploitation Read More

iPROLEPSIS networking activities Our shared vision is to establish a robust ecosystem of initiatives , where the combined strength of each project contributes to the overarching goal of advancing healthcare and well-being . By pooling our resources, knowledge, and expertise, we believe in the potential for significant benefits both for the collaborative cluster and the individual projects involved. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Key Facts keyfacts 1 Understanding Psoriatic Arthritis Learn what psoriatic arthritis is, how it’s connected to psoriasis, what symptoms to look out for, how it’s diagnosed, and how to recognise a flare. f1.1 f1.2 See related Handbook section See related Handbook section See related Handbook section See related Handbook section See related Handbook section f1.3 f1.5 F1.4 keyfacts 2 Managing Psoriatic Arthritis: Treatments and Lifestyle Learn how psoriatic arthritis is treated through medications, non-pharmacological treatments, and everyday lifestyle choices that support health and wellbeing. See related Handbook section See related Handbook section See related Handbook section See related Handbook section See related Handbook section f2.1 f2.2 f2.3 f2.4 f2.5 keyfacts 3 Living with Psoriatic Arthritis Everyday tips for balancing work, improving sleep, managing fatigue, and supporting mental wellbeing. f3.1 See related Handbook section See related Handbook section See related Handbook section See related Handbook section f3.2 f3.3 f3.4 key facts 4 Intimacy, Reproductive Health and Family Life Understanding how psoriatic arthritis may affect relationships, sexual and reproductive health, and family planning decisions. See related Handbook section See related Handbook section See related Handbook section See related Handbook section f4.1 f4.2 f4.3 f4.4

iPROLEPSIS networking activities Our shared vision is to establish a robust ecosystem of initiatives , where the combined strength of each project contributes to the overarching goal of advancing healthcare and well-being . By pooling our resources, knowledge, and expertise, we believe in the potential for significant benefits both for the collaborative cluster and the individual projects involved. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Handbook Living with Psoriatic Arthritis Handbook How will psoriatic arthritis affect me? WORK Work can provide a sense of purpose, identity, achievement, and a supportive social network, contributing positively to your emotional and physical wellbeing. While your condition may pose some challenges, people living with psoriatic arthritis can continue to work as long as their profession does not exacerbate their symptoms and worsen their health. People with certain health conditions have defined rights set out in law, designed to protect them against direct and indirect discrimination in the workplace. Your employer is legally obligated to make “reasonable accommodations” to your working environment and practices to ensure your condition does not prevent you from doing your job to the best of your ability and in a comfortable and safe environment. For most people, treatment for psoriatic arthritis will involve trying several different medications. Since many people with psoriatic arthritis have psoriasis, managing the condition can seem like treating two diseases. Some treatments work on both diseases, while others work mainly on the arthritis or skin problems. h3.1 In the European Union, the definition of reasonable accommodation at work was introduced by Article 5 of the Employment Equality Directive (Directive 2000/28/EC): “shall take appropriate measures, where needed in a particular case, to enable a person with disability to have access to, participate in, or advance in employment, or to undergo training, unless such measures would impose a disproportionate burden on the employer.” This directive has been transposed into national law in all EU member states. Research has shown that people who need workplace accommodations and effectively use them are more likely to keep a job and stay productive than those who do not use workplace accommodations (39). However, asking for workplace accommodations can be difficult. You may be concerned about being treated differently and negative reactions from your supervisor(s) or colleague(s). For this reason, you may prefer to negotiate informal workplace accommodations rather than seeking formal accommodations. Some of these accommodations may include those supported by the American College of Sports Medicine guidelines for physical activity and public health (40) and the ISO 11226 standard , https://www. iso.org/standard/25573.html , which defines joint limits to safeguard musculoskeletal health. By aligning workplace practices with these scientifically supported guidelines, employers and healthcare professionals can better accommodate the needs of their employees, fostering an inclusive and supportive work environment. Some examples follow: Recommendation #1: Avoid working for prolonged periods in the same position, whether sitting or standing. During the work shift: a continuous period of time in the standing position should not exceed 1 hour; the total time spent in a standing position should not exceed 4 hours; continuous sitting should be limited to 2 hours; when periods are dedicated to holding meetings, the duration of which should be reasonable, consideration should be given to the possibility of having them while standing or walking (41). Recommendation #2: Take frequent breaks throughout the shift. Please note that he definition of “breaks” must consider the following characteristics: Frequency: number of breaks/interruptions during the working day; Duration: micro-breaks (less than 2 minutes); short breaks (typically those that occur in the morning or afternoon, lasting between 7 and 10 minutes); or long breaks (meal breaks); and Type: passive or resting and active (including stretching or walking) (42). Thus, in an 8-hour working day, a worker should take at least a 7–10-minute break after consecutive 90-minute work periods. Recovery periods can include moments of rest or the performance of any other task to recover the muscle groups that have been worked. Within a period of at least 90 minutes, a worker should enjoy at least 30 seconds after 20 minutes of work. Both recommendations aim to address the prolonged exposure to low-intensity static load by limiting the duration of this exposure. These interventions help to alleviate fatigue and pain symptoms in the short-term, and to prevent work-related musculoskeletal injuries in the long-term. Active breaks add value; however, they do not replace the need to introduce diversity in the intensity of the mechanical load, such as rotational planes suited to the job’s demands (43). Please note that these recommendations refer to low-intensity, physically demanding tasks. Other recommendations apply to high-intensity tasks, such as those involving manual force. Recommendation #3: Physical changes to workstations work surfaces (desks) that allow alternation between standing and sitting, alone or combined with a training and information program for workers, reduce sitting time by approximately 60 minutes per working day (in the medium term, i.e., up to 3-12 months). This change in physical working conditions can bring about a behavioural change, with repercussions in an average reduction of 82 minutes in total sitting time per day (at and away from work) and in the average duration of consecutive periods of sitting (57 minutes) (42, 44). Even though workplace adaptations are consigned in the law, many people living with rheumatic and musculoskeletal diseases report a lack of understanding from their employer(s), colleague(s), and workplace doctor(s). You have options and rights; it is important to understand them and fully explore all available alternatives. If you are unsure about your rights in the workplace, please get in touch with your HR or occupational health department. More information can be found below: The Advisory, Conciliation and Arbitration Service. (ACAS) https://www.acas.org.uk/reasonable-adjustments If you require workplace adaptations, please talk to your assistant doctor about the difficulties you have been feeling and request reports to present to your employer and/or workplace doctor. See related Key Facts section SLEEP Pain, anxiety, and side effects of the medication can make it more difficult for a person with psoriatic arthritis to fall asleep and stay asleep throughout the night. In fact, about 40% of people living with psoriatic arthritis report sleep difficulties (45). Good sleep hygiene habits may help to improve sleep: develop a regular sleep routine, that is, go to bed and get up at a similar time each day; avoid caffeine, alcohol, and large meals before you go to bed; if you smoke, try to stop smoking, or at least do not smoke close to bedtime; a warm bath before bedtime may help ease pain and stiffness; listen to soothing music or sounds before going to bed; avoid watching TV and using computers, tablets, or smartphones in your bedroom; make sure your bedroom is dark, quiet, relaxing, and at a comfortable temperature. h3.2 The impact of exercising before bedtime can vary among individuals. It is essential to listen to your body, establish a consistent routine, and pay attention to how evening workouts affect your sleep patterns. If you have specific concerns about your sleep or exercise routine, it is also advisable to consult with a healthcare professional or a fitness expert. Pros: Improved sleep quality: For some people, engaging in moderate-intensity exercises a few hours before bedtime may promote better sleep quality. It can help reduce stress and anxiety, leading to a more relaxed state conducive to sleep. Body temperature regulation: Exercise increases body temperature, and the subsequent drop in temperature after exercise can signal the body that it is time to sleep. This mimics the natural temperature drop that occurs during the evening. Establishing a routine: Regular exercise, regardless of the time of day, can contribute to better sleep quality. Establishing a consistent exercise routine is often more important than the specific time of day. Cons: Stimulating effect: For some people, intense exercise close to bedtime may have a stimulating effect, making it more challenging to wind down and fall asleep. Body temperature: While the drop in body temperature after exercise can promote sleep, exercising too close to bedtime may disrupt the body’s natural cooling process, potentially interfering with sleep. Individual variability: People respond differently to exercise timing. Some may find that late-night workouts do not impact their sleep, while others may experience difficulties. Recommendations: Timing matters: Try to finish exercising at least 2-3 hours before bedtime to allow your body temperature to return to normal and your adrenaline levels to decrease. Listen to your body: Pay attention to how your body responds to evening workouts. It might be a good fit for you if it helps you relax and improves your sleep. Experiment: Everyone is different. Experiment with varying timings of exercise to see what works best for you. If evening workouts negatively impact your sleep, consider shifting them earlier. Moderation is key: Intense or vigorous exercise close to bedtime might be more likely to interfere with sleep. Opt for moderate-intensity activities in the evening (47). Nearly 50% of patients living with psoriatic arthritis report high levels of fatigue (five or higher on a 10-point scale) and consider fatigue a high-ranking problem, after joint pain and before skin issues (48). See related Key Facts section FATIGUE Problem solving, planning, prioritising, and pacing may help you cope better with your fatigue: PROBLEM SOLVING Identify factors/tasks/chores/activities that are contributing to your fatigue; Think about solutions that could help minimise the impact of these factors/tasks/chores/ activities. PLANNING Plan the tasks/chores/activities you want to complete in a day or week; Make sure to include activities that you enjoy and can improve your mood/wellbeing; Do not beat yourself up if you cannot stick to the plan. PRIORITISING Organise your tasks/chores/activities by order of importance. PACING Do not use your energy all in one go; Break the planned tasks/chores/activities into smaller portions that can be spread out over the course of a day, a week or even longer. See related Key Facts section EMOTIONAL WELLBEING Living with psoriatic arthritis can take a toll on your mental health (49, 50). You need to treat mental health symptoms as seriously as physical symptoms. Poor mental health can cause your psoriatic arthritis to flare, increase pain and fatigue, negatively affect your work and personal relationships, and limit your ability to manage your overall health. If you feel sad, hopeless, and lose interest in things you used to enjoy, talk to your doctor, and let your loved ones know what you are going through. Your doctor may redirect you to useful mental health services such as cognitive behavioural therapy (CBT) and/or they may prescribe you an antidepressant. h3.3 h3.4 Remember that you are not alone. If you need extra support, we are here to help you: NHS Mental Health Services https://www.nhs.uk/nhs-services/mental-health-services/ VERSUS ARTHRITIS / Psoriatic arthritis https://versusarthritis.org/ +44 800 520 0520 Be kind to your joints and your mind. See related Key Facts section See related Key Facts Previous page Next page

The consortium of iProlepsis project for psoriatic arthritis consists of 15 partners from 9 countries. Discover more about project by visiting our website. Sobre os parceiros do consórcio Coordenador do projeto iPROLEPSIS Universidade Aristóteles de Salónica Consórcio é constituido por 15 parceiros de 9 países. Parceiros do consórcio iPROLEPSIS

Download iProlepsis project applications for psoriatic arthritis. Aplicativos para baixar miPROLEPSIS app The miPROLEPSIS app facilitates the iPROLEPSIS-PDPID multicenter clinical study as a data collection tool that will enable the development of digital biomarkers for psoriatic arthritis symptoms and predictive models for inflammation exacerbation. More specifically, the app performs (i) passive data collection from the sensors of the smartwatch used in the study (i.e., Garmin Vivoactive 5), (ii) passive data collection from the accelerometer and gyroscope sensors of the smartphone, (iii) patient reported outcomes via questionnaires. Moreover, the app includes (i) a custom keyboard that captures the user’s typing dynamics and (ii) photo- and video-based activities for the collection of hand/feet photos and skeletal data related to joints flexibility, respectively. Note: The app can be used only by psoriatic arthritis patients that have enrolled to the PDPID study. This enrollment is available for patients in the UK, Netherlands, Portugal, and Greece. Information on how to enroll in the study and gain access to the miPROLEPSIS app will be provided soon. miPROLEPSIS app The miPROLEPSIS PDPID Study application functions as a data collection tool, utilized during the PDPID study, in order to produce datasets used for model generation and training. The app utilises both continuous and unobtrusive data collection (via bluetooth) from wearable devices, as well as user interactions (questionnaires, reporting etc). miPROLEPSIS Joint Landmarker app The miPROLEPSIS Joint Landmarker is an accompanying app of the miPROLEPSIS app that enables the video-based active tests feature. More specifically, a set of 6 hand and body movement exercises are presented and the user is asked to perform them in front of the smartphone camera. The app captures the videos and extracts skeletal data (coordinates of skeletal joints) locally. The skeletal data will be further analysed to develop digital biomarkers that assess the functionality and flexibility of joints. Note: The miPROLEPSIS Joint Landmarker app cannot be used without the miPROLEPSIS app. miPROLEPSIS Joint Landmarker app This app is a research app that accompanies the miPROLEPSIS app and aims to assess the physical functioning of people with Psoriatic Arthritis. More specifically, a set of 6 hand and body exercises are given and the user is asked to perform them in front of the smartphone camera. The app uses the collected videos to extract skeletal data (coordinates of skeletal joints), which are then sent to a cloud for further processing. Through the skeletal data processing, the aim is to identify whether a patient with Psoriatic Arthritis have difficulties in performing certain hand and body actions. The videos are immediately discarded and no personal information is retained, saved or transmitted.

iPROLEPSIS networking activities Our shared vision is to establish a robust ecosystem of initiatives , where the combined strength of each project contributes to the overarching goal of advancing healthcare and well-being . By pooling our resources, knowledge, and expertise, we believe in the potential for significant benefits both for the collaborative cluster and the individual projects involved. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Handbook Handbook Handbook Understanding Psoriatic Arthritis Handbook Sections What is psoriatic arthritis? What causes psoriatic arthritis? What are the symptoms of psoriatic arthritis? How is psoriatic arthritis diagnosed? Read Sections Living with Psoriatic Arthritis Handbook Sections Work Sleep and fatigue Emotional wellbeing Read Sections Managing Psoriatic Arthritis Handbook Sections How is psoriatic arthritis treated? Non-pharmacological treatments Self-care and lifestyle Read Sections Intimacy, Reproductive Health and Family Life Handbook Sections Relationships and sex Fertility, pregnancy, and breastfeeding Read Sections Psoriatic Arthritis Handbook Handbook

iPROLEPSIS project will perform four different clinical studies in four different counties. Learn more about clinical studies by visiting iprolepsis.eu. Sobre Estudos Clínicos iPROLEPSIS irá realizar quatro estudos clínicos diferentes: 1.iPROLEPSIS-PDPID Estudo de fenotipagem digital e fatores de inflamação da Artrite Psoriática (PsA) 2. iPROLEPSIS-MOJMI Estudo de mastócitos e imagens microvasculares e articulares baseados em optoacústica 3. iPROLEPSIS-IDBV Estudo de validação de biomarcadores digitais de inflamação. 4. iPROLEPSIS-PPIDC Estudo para a prevenção da inflamação da PsA através do cuidado digital: um estudo de intervenção. Os estudos clínicos serão realizados em 5 países: Holanda Reino Unido Portugal Grécia Alemanha Estudos Clínicos Estudo de fenotipagem digital e fatores de inflamação da PsA (iPROLEPSIS-PDPID) Coorte de desenvolvimento de biomarcadores digitais baseados em smartphones e smartwatches e baseados em Inteligência Artificial (IA) para avaliação e monitorização remota de pessoas com Artrite Psoriática (AP). Medir Desenvolver novos biomarcadores digitais para smartphones e dispositivos inteligentes (cinto, anel, câmera) para a avaliação de sintomas inflamatórios, com foco especial no reconhecimento de mudanças nos padrões de movimento, dor, fadiga, rigidez matinal em comparação com o "gold standard" – avaliação médica através da avaliação clínica das articulações, tendões e pele. Prever Prever a mudança de um estado não inflamado para inflamado utilizando três fatores desencadeantes que podem causar inflamação de longa duração em pacientes com artrite psoriática em risco de exacerbação. Esses três desencadeadores são stress, stress mecânico, e alterações no microbioma intestinal. OBJETIVOS Objetivos principais fornecer registros precisos, factuais e clinicamente relevantes do sistema autónomo de biomarcadores digitais baseado em smartphone e smartwatch, impulsionado por IA, na detecção de inflamação específica de AP ; prever inflamação específica de AP de forma precisa, factual e clinicamente relevante. Objetivos secundários determinar a confiabilidade interpessoal do sistema de biomarcadores digitais baseado em IA; determinar a validade de construto em relação à avaliação clínica da inflamação; determinar a validade do construto em relação à avaliação da inflamação pelo paciente; determinar alterações clinicamente relevantes no sistema de biomarcadores digitais suportado por IA; determinar a diferença mínima detectável no sistema de biomarcadores digitais suportado por IA; avaliar a variação interpessoal de stress, stress mecânico, e mudanças no microbioma intestinal na ocorrência de inflamação; valiar a conformidade e a satisfação dos utilizadores com o sistema de monitorização digital utilizando smartphone/smartwatch e baseado em IA. O estudo foi desenhado para desenvolver uma nova forma de medir a inflamação em pacientes com artrite psoriática. Definição de novos biomarcadores optoacústicos de psoríase e artrite psoriática (iPROLEPSIS-MOJMI) Estudo de mastócitos e imagens microvasculares e articulares baseados em optoacústica (iPROLEPSIS-MOJMI). A abordagem multiescala proposta (mesoscópica com RSOM e macroscópica com MSOT) visa explorar e definir novos biomarcadores baseados em imagens, a fim de descrever as alterações fisiopatológicas que caracterizam a doença e possam prever a transição de Psoríase para AP. Por outras palavras, espera-se que a natureza multiescala única da optoacústica torne a microvasculatura da pele uma via para efeitos sistémicos (articulares) posteriores da psoríase e, assim, melhore o prognóstico em futuros pacientes com Psoríase. OBJETIVOS Objetivos principais Definir novos mastócitos inflamatórios, biomarcadores extraídos por MSOT e RSOM em pacientes com Psoríase/AP. Quantificar as alterações dos novos mastócitos inflamatórios, biomarcadores extraídos de MSOT e RSOM com o aumento da gravidade da doença. Objetivos secundários Revelar correlações entre os mastócitos e os biomarcadores inflamatórios extraídos por MSOT e RSOM em pacientes com Psoríase/AP. Definir um novo índice derivado de mastócitos, recursos baseados em MSOT e RSOM, para permitir a detecção precoce de AP em pacientes com Psoríase ou alto risco de desenvolver Psoríase. Estudo de validação de biomarcadores digitais de inflamação (iPROLEPSIS-IDBV) Encontrar pessoas que transitam de um estado saudável para pessoas com inflamação é uma tarefa difícil na Doença Inflamatória Imunomediada (IMID). Os sintomas iniciais são semelhantes aos de qualquer outro distúrbio músculo-esquelético, como dores nas costas, nos dedos ou problemas no tendão de Aquiles. Com o tempo, os sintomas podem desaparecer temporariamente, tornar-se crónicos ou tornar-se tão graves que é necessário atendimento médico. A identificação precoce de pessoas com IMID beneficiaria consideravelmente a qualidade de vida, mantê-las-ia no trabalho e evitaria custos elevados com cuidados de saúde devido a medicamentos caros. Os biomarcadores digitais irão dar-nos, pela primeira vez, a capacidade de estudar a conversão de distúrbios musculoesqueléticos em doenças inflamatórias das articulações e tendões imunomediadas. O objetivo deste estudo é validar os resultados dos biomarcadores digitais na AP em pacientes com Psoríase. OBJETIVOS Objetivos principais validar registros precisos, factuais e clinicamente relevantes do sistema autónomo de biomarcadores digitais baseado em smartphone e smartwatch, e suportados por IA, na detecção de inflamação específica de articulações ou tendões do IMID. Objetivos secundários avaliar a aceitação e aceitabilidade do biomarcador digital "in-the-wild"; avaliar o impacto dos dados que faltam na detecção de inflamação; avaliar o número de falsos positivos quando os dados são capturados "in-the-wild"; avaliar a variação interpessoal de stress e stress mecânico. O objetivo é identificar a inflamação com um dispositivo médico baseado em software. Este software consistirá num algoritmo que analisa dados recolhidos "in-the-wild" por meio de dispositivos inteligentes: smartphone, smartwatch, anel. Prevenção da inflamação da AP através de cuidados digitais: um estudo de intervenção (iPROLEPSIS-PPIDC) Este estudo combina as descobertas dos biomarcadores digitais mais recentes, as primeiras descobertas dos fatores desencadeadores: stress, stress mecânico e alterações no microbioma do estudo de fenotipagem digital, bem como fatores de inflamação da AP (iPROLEPSIS-PDPID), para fornecer uma abordagem personalizada para lidar com os desencadeadores com intervenções de última geração. OBJETIVOS Objetivos principais Em pacientes com AP com baixa atividade da doença, uma intervenção personalizada sobre alimentação, atividade física e stress, com base num perfil individual de stress, stress mecânico e microbioma, será comparada aos cuidados habituais no desenvolvimento da inflamação, conforme detectado pelo sistema de biomarcadores digitais recentemente desenvolvidos e pelo exame clínico. Objetivos secundários avaliar a aceitação e a aceitabilidade do biomarcador digital e da intervenção como parte do tratamento médico normal entre pacientes, médicos e enfermeiros; avaliar a adesão à intervenção personalizada.