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< BACK "The Kite" Breathing Serious Game: Agile Co-Design for Psoriatic Arthritis Jul 31, 2024 Enhancing PsA Management through Innovative Breathing Exercises and Game-Based Therapy Latest research initiative under the iPROLEPSIS project: “The Kite” Breathing Serious Game: Agile Co-Design for Psoriatic Arthritis presented at IEEE MELECON 2024. This study is part of a broader effort to develop and validate innovative digital biomarkers for managing Psoriatic Arthritis (PsA) through the Artificial Intelligence-Personalised Game Suite (AI-PGS). Abstract: Serious Games (SGs) have the potential to provide clinical care and enhance patients’ quality of life, while incorporating an element of entertainment. As part of the iPROLEPSIS Horizon Europe project, we introduce two Sensorimotor Art games designed as SGs to assist Psoriatic Arthritis (PsA) patients in managing their symptoms. These SGs provide a platform for self-expression and pain relief through engaging in rhythmic puzzle activities. The co-design process for the proposed Sensorimotor Art games followed an agile methodology, involving 14 experts (including clinicians, researchers, and game developers), to gather feedback on game requirements, storyboards, and mechanics. From the thematic analysis of the transcribed discussion, four main themes emerged, namely: Clinical value (Theme 1), Motor skills and adaptation (Theme 2), Creative engagement (Theme 3), and Feedback and future directions (Theme 4). Clinical value underlines the therapeutic benefits of Sensorimotor Art games for pain distraction and emotional well-being. Motor skills and adaptation focus on hand/finger use and adapting games for older patients. Creative engagement emphasizes fostering creativity, a positive environment, and goal achievement. Finally, feedback and future directions highlight the importance of continuous feedback and occupational therapists’ involvement in coming sessions. The development of Sensorimotor Art games lays the groundwork for digital interventions to alleviate psychological distress and improve fine motor symptoms in PsA patients. At the same time, these SGs can also provide insights to healthcare providers and policymakers for developing future digital solutions tailored to PsA patients. Read the full publication: https://zenodo.org/records/13141465 IEEE_MELECON_2024 .pdf Download PDF • 1.33MB 1/1 PREVIOUS NEXT

< BACK 6th iPROLEPSIS Plenary Meeting Held in Oxford May 15, 2025 Partners Shared Progress and Plans for the Future The iPROLEPSIS consortium came together on 13–14 May 2025 for its 6th Plenary Meeting , hosted by the University of Oxford in the beautiful city of Oxford, UK. The two-day meeting covered updates on various parts of the project, including system development, clinical studies, data harmonisation, and user needs. It was a great opportunity for partners to share progress, discuss challenges, and align on next steps. Workshops helped address open issues and refine priorities for the coming months. On the first day, the consortium also welcomed feedback from the External Advisory Board , offering helpful guidance on recent developments. A warm thank you to the University of Oxford for hosting and to all participants for the active and constructive discussions! IMG_9529.jpg IMG_9431.jpg IMG_9527.jpg IMG_9529.jpg 1/8 PREVIOUS NEXT

iPROLEPSIS project news Nov 24, 2025 iPROLEPSIS Games Showcased at Lisboa Games Week 2025 The FMH/IST-ULisboa team presented the iPROLEPSIS Games, connecting with the gaming community and industry stakeholders READ MORE Oct 29, 2025 World Psoriasis Day: iPROLEPSIS featured by HaDEA On World Psoriasis Day, the European Health and Digital Executive Agency (HaDEA) highlights how the iPROLEPSIS project is advancing early detection and personalised care for psoriatic arthritis READ MORE Oct 8, 2025 iPROLEPSIS presented at the MULTIPULM project kick-off meeting iPROLEPSIS tools to be adapted for clinical studies in Brazil, Serbia, and Türkiye READ MORE Jul 24, 2025 iPROLEPSIS Games Pitch video from HiTech 2025 iPROLEPSIS Games presented during the HiSeedTech programme READ MORE Jul 2, 2025 iPROLEPSIS Newsletter No. 9 Latest News from iPROLEPSIS READ MORE Jun 2, 2025 Khalifa University Features iPROLEPSIS in Research News AI, Apps and Arthritis: A Digital Leap in Psoriatic Care READ MORE May 16, 2025 Call for Workshop Papers: AI-enabled Digital Health Tools for Non-Communicable Diseases: From Concepts to Impact A joint workshop by iPROLEPSIS and AI-PROGNOSIS at IEEE HealthCom 2025 in Abu Dhabi, focusing on AI-enabled Digital Health Tools for Non-Communicable Diseases READ MORE Nov 6, 2025 iPROLEPSIS Newsletter No. 10 Latest News from iPROLEPSIS READ MORE Oct 29, 2025 World Psoriasis Day 2025: Advancing Prevention and Care On World Psoriasis Day, iPROLEPSIS highlights ongoing efforts to improve early detection, prevention, and digital support for people living with psoriasis and psoriatic arthritis READ MORE Oct 2, 2025 iPROLEPSIS at the European Researchers’ Night 2025 Presentation of the iPROLEPSIS Games in Oeiras, Portugal by FMH/IST-ULisboa researchers READ MORE Jul 18, 2025 iPROLEPSIS at GRAPPA 2025: Advancing Digital Tools for Psoriatic Arthritis Care Exploring how digital biomarkers can support hand function assessment in real-world settings READ MORE Jun 27, 2025 iPROLEPSIS Games Presented at HiTech Program in Lisbon FMH/IST-ULisboa team showcased the project’s serious games to investors and health innovation experts READ MORE May 19, 2025 iPROLEPSIS Research on Digital Rheumatology Published in The Lancet eClinicalMedicine New Publication Highlights Explainable AI Tools, Digital Biomarkers, and Multimodal Disease Monitoring for PsA READ MORE May 15, 2025 6th iPROLEPSIS Plenary Meeting Held in Oxford Partners Shared Progress and Plans for the Future READ MORE Nov 3, 2025 iPROLEPSIS at IEEE HealthCom 2025: AI-Enabled Digital Health for Psoriatic Arthritis Project researchers presented new studies, co-chaired a workshop, and joined a panel on digital innovation in healthcare in Abu Dhabi READ MORE Oct 14, 2025 The iPROLEPSIS Learning Hub Has Been Renewed A refreshed space to learn more about psoriatic arthritis READ MORE Sep 11, 2025 Digital Innovation for Psoriatic Arthritis Prevention An interview with iPROLEPSIS coordinators in Thessalonikeon Polis on how digital tools, wearables, and AI can help prevent psoriatic arthritis READ MORE Jul 17, 2025 iPROLEPSIS, AI-PROGNOSIS & REBECCA: A Thematic Cluster on AI-Driven Digital Health Three EU-funded projects exploring real-world data, wearables, and personalised care in healthcare innovation READ MORE Jun 5, 2025 iPROLEPSIS Presented at EIT Health Morning Health Talk in Athens Co-Creating Health Innovation Ecosystems: Empowering Providers and Citizens Beyond Financial Incentives READ MORE May 19, 2025 iPROLEPSIS presented at the COMFORT-EU Plenary Meeting Strengthening Collaboration in AI for Healthcare READ MORE 1 2 3 4 5 1 ... 1 2 3 4 5 ... 5

The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalized digital care ecosystem. iPROLEPSIS is a s olution for psoriatic arthritis The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalised digital care ecosystem. ABOUT CONSORTIUM CONTACT US November 2025 TODAY Mon Tue Wed Thu Fri Sat Sun 27 28 29 30 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 1 2 3 4 5 6 7 Upcoming events Psoriatic Arthritis (PsA) is a chronic progressive inflammatory disease affecting 1-2% of the general population, while manifesting in up to 30% of people with psoriasis (PsO). Project vision and impact iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with PsA. The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real World Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. DISCOVER MORE Project objectives and work packages iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA) and has 6 Work Packages of the project that will bring together various and complementary expertise from consortium partners. DISCOVER MORE About project 15 Partners 9 Countries 48 m Project duration € 6,4M Total budget The core activity domains Establishment • The foundation for the project’s research activities is laid by means of an extensive exploration of the available literature and data and the design of the clinical data collection and validation studies; • Participatory design supporting the development of a user-oriented ecosystem of solutions will be employed to establish a framework for trustworthy AI-based R&D. Validation • The design and implementation of the clinical studies that will collect research data, validate the inflammatory symptoms digital biomarkers in individuals at risk of PsA and PSO patients, and evaluate the efficacy of the digital care tools with respect to prevention of inflammation exacerbation. Research and development • Research on multimodal data to reveal key PsA inflammation drivers, provide digital biomarkers of PsA inflammatory symptoms, and explore the effect of PsA on the joints and skin microvasculature, as well as the role of mast cells in PsA transition; • Synthesise the outcomes into a multiscale/multifactorial model of the health-to-PsA transition; • Deliver the integrated iPROLEPSIS digital health ecosystem comprising tools for personalised preventive PsA care, to empower patients and HCPs. Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Handbook Handbook 2 Psoriatic Arthritis Key Facts Key Facts Psoriatic Arthritis Handbook Handbook Quizzes about Psoriatic Arthritis Take a Quiz Project news Handbook Handbook 2 iPROLEPSIS Games Showcased at Lisboa Games Week 2025 Read More iPROLEPSIS Newsletter No. 10 Read More iPROLEPSIS at IEEE HealthCom 2025: AI-Enabled Digital Health for Psoriatic Arthritis Read More DISCOVER MORE Contact us We welcome your comments or questions about iPROLEPSIS project! CONTACT US

< BACK Empowering Girls in Tech: Celebrating GirlSteam 2024 Apr 25, 2024 Inspiring the Next Generation of Women in Information and Communication Technologies On 24th April, we celebrated International Girls in Information and Communication Technology Day – GirlSteam 2024, which is part of the larger initiative, International Girls in ICT Day (Girls in ICT 2024). This annual occasion is an international effort promoted by the United Nations agency ITU (International Telecommunication Union). During this event, Bárbara Ramalho (PhD student from FMH-ULisboa) presented the iPROLEPSIS project and the iPROLEPSIS Games . The primary aim was to raise awareness and encourage girls and young women to explore studies and careers in Information and Communication Technologies, especially in the field of Serious Games. iPROLEPSIS games 2.jpeg iPROLEPSIS games 1.jpeg Event banner.jpeg iPROLEPSIS games 2.jpeg 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS Project Presented at HUMAN Lab Meetup Jul 15, 2024 Enhancing Learning Through Innovative Serious Games and Digital Interventions On 8 July 2024, the HUMAN Lab meetup was organised by Universidade de Lisboa (Instituto Superior Técnico, IST). During the event, Bárbara Ramalho and Hugo Escobar from FMH/IST-ULisboa presented the iPROLEPSIS project and the iPROLEPSIS Games. They discussed the project's main goals, motivations, and key milestones, providing insights into their roles in the design and development of serious games. The presentation also addressed the expected outcomes of the project, emphasising how these innovative tools are designed to enhance learning experiences and offer effective digital interventions. 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS, AI-PROGNOSIS & REBECCA: A Thematic Cluster on AI-Driven Digital Health Jul 17, 2025 Three EU-funded projects exploring real-world data, wearables, and personalised care in healthcare innovation Have you ever asked yourself how to make AI really effective along the patient journey? That was one of the first questions we asked ourselves when we launched our project. Along the way, we discovered we weren’t alone – many other research initiatives working with AI in healthcare were asking the same thing. That’s why we decided to take a step forward and create a cluster : a concrete way to collaborate, foster the impact of our solutions, and improve them through scientific exchange and an open science approach. AI-PROGNOSIS, iPROLEPSIS, and REBECCA – three EU-funded projects to advance patient-centric AI in healthcare. Focusing on Parkinson’s disease (PD), AI-PROGNOSIS is developing a suite of AI-powered tools for both patients and clinicians . These include early risk assessment, symptom monitoring, and medication support – based on real-world data from wearables and patient self-reports. It’s about enabling timely, data-driven decisions and bringing predictive analytics to the heart of primary care. iPROLEPSIS is building a comprehensive digital health ecosystem for psoriatic arthritis (PsA). It brings together a multisource biobank, a smartphone-based app powered by digital biomarkers and AI-driven predictive models, and an intervention module featuring therapeutic games, lifestyle coaching, and sleep support. The goal? To reshape the way we monitor and treat chronic inflammatory diseases through personalised mobile health solutions. Finally, REBECCA is working to improve long-term care for breast cancer survivors. By combining electronic health records with data from wearables and behaviour tracking , it generates real-world evidence on patients’ emotional, functional, and quality-of-life needs. Its explainable AI platform also supports caregivers and families via a dedicated app, empowering a more holistic approach to survivorship. What will we do together? We aim to contribute to the discussion on how AI-based digital health can support medical decision-making and real-time monitoring within daily hospital routines. I ntegrating AI into clinical practice is no easy task. Our solutions are designed to enable real-time health monitoring, informed decision-making, and disease management by leveraging biometric, behavioral, and clinical data –maximizing the impact along the patient journey. Another area of strong interest is the development of digital infrastructures that integrate wearable, clinical, behavioral, and environmental datasets. We believe these can be analyzed collectively through AI to generate real-world evidence and support both predictive and causal modeling – helping to guide research and inform treatment planning in more meaningful ways. Cluster.png Cluster.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Newsletter No. 9 Jul 2, 2025 Latest News from iPROLEPSIS Welcome to the ninth edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter_Issue No. 9_July 2025 .pdf Download PDF • 3.75MB iPROLEPSIS_newsletter cover.png iPROLEPSIS_newsletter cover.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS presented at the 15th Portuguese Rheumatology Congress Oct 27, 2023 iPROLEPSIS project and iPROLEPSIS-PDPID study presented at the 15th Portuguese Rheumatology Congress On October 27, 2023, the Portuguese Society of Rheumatology (SPR) , a dedicated partner of iPROLEPSIS , took the stage at the 15th Portuguese Rheumatology Congress (XXV Congresso Português de Reumatologia) , the event attended by around 700 individuals, mainly rheumatologists and GPs. Cátia Gonçalves, Reuma.pt Study Coordinator, and Ana M. Rodrigues, Reuma.pt National Coordinator and Assistant Professor at NOVA Medical School, provided a comprehensive overview of the iPROLEPSIS project, its goals, and clinical studies. They also introduced the iPROLEPSIS-PDPID study , focusing on PsA digital phenotyping and inflammation drivers. Portuguese Rheumatology centres were invited to participate in the iPROLEPSIS-PDPID study, marking a significant step in advancing our research. News & Events iPROLEPSIS.png News & Events iPROLEPSIS.png 1/1 PREVIOUS NEXT

< BACK Psoriasis Awareness Month - August 2024 Aug 20, 2024 From Psoriasis to Psoriatic Arthritis: The Importance of Awareness In August, we marked Psoriasis Awareness Month, raising awareness for the millions living with psoriasis, a chronic autoimmune disease that affects the skin and causes painful and itchy flare-ups. Beyond the visible symptoms, psoriasis can significantly impact mental health and overall quality of life. An important aspect of awareness is the link between psoriasis and psoriatic arthritis, a condition that develops in 20-40% of individuals with psoriasis. Psoriatic arthritis can lead to joint pain, stiffness, and swelling, potentially causing long-term disability if left untreated. This makes early detection and comprehensive management essential for improving patient outcomes. Through continued advocacy and education, we can help those affected by psoriasis seek timely support and prevent the progression to psoriatic arthritis. 1/4 PREVIOUS NEXT

< BACK Trustworthy AI in Digital Health: The iPROLEPSIS Approach Mar 28, 2025 iPROLEPSIS at Health Data Summit 2025 At Health Data Summit 2025 , organised by The European Institute for Innovation Through Health Data on March 18–19 in Brussels , Vasileios Charisis, PhD , from the Signal Processing & Biomedical Technology Unit - AUTH , presented iPROLEPSIS during the session “Trustworthy AI in Digital Health: From Guidelines to Practice”. The presentation outlined the methodology used in iPROLEPSIS to develop a trustworthy AI (TAI) framework tailored to the project’s specific needs. A case study on the Lifestyle Recommendation Engine demonstrated how it aligns with TAI principles and recommendations . The session also featured other Horizon Europe projects , including AI-PROGNOSIS, TRUSTroke, and STRATIFYHF , which presented their approaches to developing trustworthy digital health solutions . By bringing together different initiatives, the session highlighted the importance of trustworthy AI in healthcare , ensuring transparency, reliability, and ethical considerations in digital health innovations . 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS Newsletter No. 5 Jul 10, 2024 Discover Insights from Clinicians, Collaborative Efforts, and Key Events Welcome to the fifth edition of the iPROLEPSIS project newsletter. In this issue, we bring you insightful interviews with clinicians specialising in psoriatic arthritis, insights into recent clustering and networking activities, and reflections on key past events. iPROLEPSIS_Newsletter No. 5 .pdf Download PDF • 8.01MB 1/1 PREVIOUS NEXT