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The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalized digital care ecosystem. iPROLEPSIS is a s olution for psoriatic arthritis The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalised digital care ecosystem. ABOUT CONSORTIUM CONTACT US April 2026 TODAY Mon Tue Wed Thu Fri Sat Sun 30 31 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 1 2 3 4 5 6 7 8 9 10 Upcoming events Psoriatic Arthritis (PsA) is a chronic progressive inflammatory disease affecting 1-2% of the general population, while manifesting in up to 30% of people with psoriasis (PsO). Project vision and impact iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with PsA. The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real World Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. DISCOVER MORE Project objectives and work packages iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA) and has 6 Work Packages of the project that will bring together various and complementary expertise from consortium partners. DISCOVER MORE About project 15 Partners 9 Countries 48 m Project duration € 6,4M Total budget The core activity domains Establishment • The foundation for the project’s research activities is laid by means of an extensive exploration of the available literature and data and the design of the clinical data collection and validation studies; • Participatory design supporting the development of a user-oriented ecosystem of solutions will be employed to establish a framework for trustworthy AI-based R&D. Validation • The design and implementation of the clinical studies that will collect research data, validate the inflammatory symptoms digital biomarkers in individuals at risk of PsA and PSO patients, and evaluate the efficacy of the digital care tools with respect to prevention of inflammation exacerbation. Research and development • Research on multimodal data to reveal key PsA inflammation drivers, provide digital biomarkers of PsA inflammatory symptoms, and explore the effect of PsA on the joints and skin microvasculature, as well as the role of mast cells in PsA transition; • Synthesise the outcomes into a multiscale/multifactorial model of the health-to-PsA transition; • Deliver the integrated iPROLEPSIS digital health ecosystem comprising tools for personalised preventive PsA care, to empower patients and HCPs. Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Handbook Handbook 2 Psoriatic Arthritis Key Facts Key Facts Psoriatic Arthritis Handbook Handbook Quizzes about Psoriatic Arthritis Take a Quiz Project news Handbook Handbook 2 iPROLEPSIS Newsletter No. 11 Read More AI-Driven Early Prediction and Personalised Care | iPROLEPSIS, AI-PROGNOSIS & REBECCA Read More Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs Read More DISCOVER MORE Contact us We welcome your comments or questions about iPROLEPSIS project! CONTACT US

iPROLEPSIS project newsletter Mar 10, 2026 Issue No. 11 iPROLEPSIS project newsletter No 11 Welcome! This is the 11th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Nov 6, 2025 Issue No. 10 iPROLEPSIS project newsletter No 10 Welcome! This is the 10th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Jul 1, 2025 Issue No. 9 iPROLEPSIS project newsletter No 9 Welcome! This is the 9th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Apr 28, 2025 Issue No. 8 iPROLEPSIS project newsletter No 8 Welcome! This is the 8th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Jan 28, 2025 Issue No. 7 iPROLEPSIS project newsletter No 7 Welcome! This is the 7th edition of the Newsletter series of the iPROLEPSIS project. In this issue, we highlight the insights on the future of digital biomarkers in rheumatology care, offer key information about PsA and practical advice to improve daily life, update about past events. READ THE NEWSLETTER Oct 9, 2024 Issue No. 6 iPROLEPSIS project newsletter No 6 Welcome! This is the 6th edition of the Newsletter series of the iPROLEPSIS project. In this issue, we highlight the release of the miPROLEPSIS and miPROLEPSIS Joint Landmarker apps, recent publications, reflections on Psoriatic Arthritis Awareness Day and Psoriasis Awareness Month, and key takeaways from recent events. READ THE NEWSLETTER Jul 9, 2024 Issue No. 5 iPROLEPSIS project newsletter No 5 Welcome! This is the 5th edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the updates and progress of the project activities, synergies and events. READ THE NEWSLETTER Mar 7, 2024 Issue No. 4 iPROLEPSIS project newsletter No 4 Welcome! This is the 4th edition of the Newsletter series of the iPROLEPSIS project. Let's explore the latest developments and advancements in our project activities, collaborations, and upcoming events. READ THE NEWSLETTER Nov 30, 2023 Issue No. 3 iPROLEPSIS project newsletter No 3 Welcome! This is the 3rd edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the updates and progress of the project activities, synergies and events. READ THE NEWSLETTER Sep 5, 2023 Issue No. 2 iPROLEPSIS project newsletter No 2 Welcome! This is the 2nd edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the transformative power of user research and co-creation in the healthcare innovation research process. READ THE NEWSLETTER Jul 3, 2023 Issue No. 1 iPROLEPSIS project newsletter No 1 Welcome! This is the 1st edition of the newsletter series of the iPROLEPSIS project! The 1st newsletter informs you about the iPROLEPSIS project, its vision, pillars and objectives, and the partners involved. READ THE NEWSLETTER

Download needed promo materials for iProlepsis project for psoriatic arthritis, such as posters, flyers, logos, and color palete. Promo materials to download 01 iPROLEPSIS Poster (A0) 02 iPROLEPSIS Flyer (A5) 03 iPROLEPSIS Roll-Up Poster Logo and color palette to download PNG, transparent background SVG, transparent background SVG, transparent background #212178 #B380FF #FFAACC #37C8AB #DEEBF7 PNG, white background WEBP, transparent background

< BACK Calling for Influencers: Join iPROLEPSIS as an Ambassador for Psoriatic Arthritis Feb 27, 2024 Join the iPROLEPSIS Initiative: Become an Ambassador for the iPROLEPSIS Project Join the iPROLEPSIS initiative! Calling all influencers, psoriatic arthritis warriors and health advocates to become iPROLEPSIS Ambassadors ! Our mission is to shed light upon the health-to-PsA transition through groundbreaking AI-driven analysis and cutting-edge technology. We are creating a digital health ecosystem for personalised psoriatic arthritis risk prediction and management. Are you passionate about health advocacy and psoriatic arthritis awareness? Become an iPROLEPSIS Ambassador and be a part of the change! Here is how you can make a difference as an iPROLEPSIS Ambassador: Promote the iPROLEPSIS mission Share iPROLEPSIS updates and developments Share personal stories and insights Ready to be a part of the change? Contact us at info@iprolepsis.eu , and we will provide you with more details. * Please note that this is voluntary, and no monetary compensation is offered. AI-PROGNOSIS events (8).png AI-PROGNOSIS events (8).png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS 5th Plenary Meeting in Athens Dec 5, 2024 Advancing the Development of Digital Solutions for Psoriatic Arthritis Care The iPROLEPSIS consortium gathered in Athens, Greece, on 2-3 December 2024, for the 5th Plenary Meeting. Hosted by Netcompany-Intrasoft and Wellics, this two-day event brought together consortium partners, the External Advisory Board (EAB), and the Project Officer (PO) to discuss key updates and map out the next steps in developing a personalised digital care ecosystem for people with Psoriatic Arthritis (PsA). The meeting focused on project updates, key achievements, and future plans for the Psoriatic Arthritis digital care ecosystem. Day 1 covered progress in the project, co-creation activities, and updates from various work packages. The team also demonstrated the iPROLEPSIS tools, including the miPROLEPSIS apps, HCP’s dashboard, and the Lifestyle Recommendation System. On Day 2, workshops were held on study designs, ecosystem development, and predictive models. Discussions also focused on data governance and dissemination strategies. 1/8 PREVIOUS NEXT

< BACK iPROLEPSIS Newsletter No. 9 Jul 2, 2025 Latest News from iPROLEPSIS Welcome to the ninth edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter_Issue No. 9_July 2025 .pdf Download PDF • 3.75MB iPROLEPSIS_newsletter cover.png iPROLEPSIS_newsletter cover.png 1/1 PREVIOUS NEXT

< BACK Empowering Girls in Tech: Celebrating GirlSteam 2024 Apr 25, 2024 Inspiring the Next Generation of Women in Information and Communication Technologies On 24th April, we celebrated International Girls in Information and Communication Technology Day – GirlSteam 2024, which is part of the larger initiative, International Girls in ICT Day (Girls in ICT 2024). This annual occasion is an international effort promoted by the United Nations agency ITU (International Telecommunication Union). During this event, Bárbara Ramalho (PhD student from FMH-ULisboa) presented the iPROLEPSIS project and the iPROLEPSIS Games . The primary aim was to raise awareness and encourage girls and young women to explore studies and careers in Information and Communication Technologies, especially in the field of Serious Games. iPROLEPSIS games 2.jpeg iPROLEPSIS games 1.jpeg Event banner.jpeg iPROLEPSIS games 2.jpeg 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS at IEEE HealthCom 2025: AI-Enabled Digital Health for Psoriatic Arthritis Nov 3, 2025 Project researchers presented new studies, co-chaired a workshop, and joined a panel on digital innovation in healthcare in Abu Dhabi The iPROLEPSIS team participated in the IEEE HealthCom 2025 Conference , held 21–23 October 2025 and hosted by Khalifa University in Abu Dhabi, United Arab Emirates . The event gathered international experts in digital health , artificial intelligence , and biomedical technologies to discuss how AI can improve the understanding and management of non-communicable diseases . Modeling joint swelling through smartphone photographs Giorgos Apostolidis from the Signal Processing & Biomedical Technology Unit – AUTH presented the paper “Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs”. By analyzing smartphone photos of hands, the study showcased that a digital estimation of joint thickness, namely effective width , with the aid of a logistic regression model , can serve as an effective tool for detecting interphalangeal joint swelling in people with PsA .This approach was validated on a real-world dataset collected within the PDPID study . Giorgos Apostolidis (Signal Processing & Biomedical Technology Unit – AUTH) Designing exergames for Psoriatic Arthritis care Prof. Leontios Hadjileontiadis (AUTH) presented the paper “Designing Exergames for Psoriatic Arthritis: The Spy and Zen Forest Paradigms”. The Spy and Zen Forest exergames were co-designed to complement PsA care by making therapeutic exercises more engaging and accessible at home. Using real-time body tracking on mobile devices , these games promote dynamic movement to enhance mobility and strength, and calm stretching for flexibility and relaxation. Prof. Leontios Hadjileontiadis (Signal Processing & Biomedical Technology Unit-AUTH) Panel discussion: Digital Bridges for Better Health Project Coordinator Prof. Leontios Hadjileontiadis , Scientific & Technical Manager Vasileios Charisis , and Stelios Hadjidimitriou from the Signal Processing & Biomedical Technology Unit – AUTH , together with Dr. Kosmas Dimitropoulos from the Centre for Research & Technology Hellas (CERTH) and Prof. Mohamed Seghier from Khalifa University , participated in the panel discussion “Digital Bridges for Better Health: AI Innovation from Europe to the Middle East and North Africa (MENA),” moderated by Giorgos Apostolidis. The panel provided insights into: The technical challenges in integrating AI with existing healthcare IT systems, How key stakeholders can collaborate to ensure AI digital health tools are user-friendly and clinically relevant, The role of patient engagement and digital literacy in the effectiveness of AI tools in chronic disease management How socio-cultural differences between Europe and MENA can influence the design and adoption of AI digital health solutions What are the key regulatory challenges in Europe and MENA regarding the use of AI in healthcare and what joint efforts can be undertaken to harmonize standards in these regions During the session, the iPROLEPSIS project and its AI-enabled digital health tools for assisting Psoriatic Arthritis management and care were highlighted as a case study of AI solutions with potential to improve outcomes for people with non-communicable diseases . Panel discussion "Digital Bridges for better health: AI Innovation from Europe to the Middle East and North Africa (MENA)" Workshop chairing Scientific & Technical Manager Vasileios Charisis from the Signal Processing & Biomedical Technology Unit-AUTH co-chaired the workshop "AI-enabled Digital Health Tools for Non-Communicable Diseases: From Concepts to Impact" . The workshop was co-organised with the AI-PROGNOSIS Horizon Europe project and included research works in the fields of psoriatic arthritis, Parkinson's disease, multiple sclerosis and post-stroke rehabilitation. Two of the presented papers stem from research carried out within iPROLEPSIS: Apostolidis et al., Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs Ramalho et al., Designing exergames for psoriatic arthritis: The Spy and Zen Forest paradigms Workshop “AI-enabled Digital Health Tools for Non-Communicable Diseases: From Concepts to Impact” The iPROLEPSIS and AI-PROGNOSIS teams from AUTH participated jointly at IEEE HealthCom 2025 , highlighting their shared commitment to advancing AI-enabled digital health solutions that enhance the understanding, early detection, and management of chronic diseases . iPROLEPSIS and AI-PROGNOSIS team members PXL_20251021_131742947.MP.jpg 2.jpg IMG_2954.jpg PXL_20251021_131742947.MP.jpg 1/11 PREVIOUS NEXT

< BACK iPROLEPSIS Project Presented at HUMAN Lab Meetup Jul 15, 2024 Enhancing Learning Through Innovative Serious Games and Digital Interventions On 8 July 2024, the HUMAN Lab meetup was organised by Universidade de Lisboa (Instituto Superior Técnico, IST). During the event, Bárbara Ramalho and Hugo Escobar from FMH/IST-ULisboa presented the iPROLEPSIS project and the iPROLEPSIS Games. They discussed the project's main goals, motivations, and key milestones, providing insights into their roles in the design and development of serious games. The presentation also addressed the expected outcomes of the project, emphasising how these innovative tools are designed to enhance learning experiences and offer effective digital interventions. 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS, AI-PROGNOSIS & REBECCA: A Thematic Cluster on AI-Driven Digital Health Jul 17, 2025 Three EU-funded projects exploring real-world data, wearables, and personalised care in healthcare innovation Have you ever asked yourself how to make AI really effective along the patient journey? That was one of the first questions we asked ourselves when we launched our project. Along the way, we discovered we weren’t alone – many other research initiatives working with AI in healthcare were asking the same thing. That’s why we decided to take a step forward and create a cluster : a concrete way to collaborate, foster the impact of our solutions, and improve them through scientific exchange and an open science approach. AI-PROGNOSIS, iPROLEPSIS, and REBECCA – three EU-funded projects to advance patient-centric AI in healthcare. Focusing on Parkinson’s disease (PD), AI-PROGNOSIS is developing a suite of AI-powered tools for both patients and clinicians . These include early risk assessment, symptom monitoring, and medication support – based on real-world data from wearables and patient self-reports. It’s about enabling timely, data-driven decisions and bringing predictive analytics to the heart of primary care. iPROLEPSIS is building a comprehensive digital health ecosystem for psoriatic arthritis (PsA). It brings together a multisource biobank, a smartphone-based app powered by digital biomarkers and AI-driven predictive models, and an intervention module featuring therapeutic games, lifestyle coaching, and sleep support. The goal? To reshape the way we monitor and treat chronic inflammatory diseases through personalised mobile health solutions. Finally, REBECCA is working to improve long-term care for breast cancer survivors. By combining electronic health records with data from wearables and behaviour tracking , it generates real-world evidence on patients’ emotional, functional, and quality-of-life needs. Its explainable AI platform also supports caregivers and families via a dedicated app, empowering a more holistic approach to survivorship. What will we do together? We aim to contribute to the discussion on how AI-based digital health can support medical decision-making and real-time monitoring within daily hospital routines. I ntegrating AI into clinical practice is no easy task. Our solutions are designed to enable real-time health monitoring, informed decision-making, and disease management by leveraging biometric, behavioral, and clinical data –maximizing the impact along the patient journey. Another area of strong interest is the development of digital infrastructures that integrate wearable, clinical, behavioral, and environmental datasets. We believe these can be analyzed collectively through AI to generate real-world evidence and support both predictive and causal modeling – helping to guide research and inform treatment planning in more meaningful ways. Cluster.png Cluster.png 1/1 PREVIOUS NEXT

< BACK Federated AI for Privacy-Preserving Omics Profiling seminar Jun 18, 2024 Advancing Knowledge in Privacy-Preserving AI for Omics Profiling On 18 June 2024, iPROLEPSIS had the opportunity to attend an online seminar organised by our sister project, IMMEDIATE EU Project. The seminar's topic was Federated AI for Privacy-Preserving Omics Profiling, presented by Prof. Dr. Jan Baumbach. Prof. Baumbach is the chair of the Computational Systems Biology lab at the University of Hamburg and leads the Computational BioMedicine group at the University of Southern Denmark. A big thank you to Prof. Baumbach for sharing his expertise and insights on this cutting-edge topic! 1/14 PREVIOUS NEXT

< BACK Advancing Digital Health Solutions: Updates on User Research and Co-Creation Nov 20, 2023 Navigating the Development of PDPID-App, Insights from Co-Creation Sessions Updates on user research and co-creation The current status of user research and co-creation involves a dedicated focus on advancing the development of the PDPID-app , scheduled for delivery before January 2023. In early October 2023, Erasmus MC ( EMC) conducted a co-creation session with patient partners to assess the general looks and feel of the User Interface (UI) and identify points to improve the app's usability. In apps used for medical data collection, it is of utmost importance that users know what is expected of them. Furthermore, users should be engaged with the app to a level that minimises missing data. Following this, bi-weekly meetings with patient partners were established to maintain alignment with their ideas. Furthermore, project partner FACULDADE DE MOTRICIDADE HUMANA (FMH-ULISBOA) is developing storyboards for the personalised gaming suite . Three co-creation sessions have been executed: one with healthcare professionals and two with patient partners. Additionally, project partners The Centre for Research and Technology Hellas (CERTH) and FACULDADE DE MOTRICIDADE HUMANA (FMH-ULISBOA) have been working with the clinical partners to identify movements for the video analysis tasks that will be included in the iPROLEPSIS-PDPID study. Multiple hand gestures and full-body movements have been identified for further assessment. Key take-away messages The development of the Digital health tools is still at an early stage. However, several take-away messages from the discussions about the PDPID app are : The general looks and UI of the miPROLEPSIS app have been approved by the patient partners. Even though the PDPID-app is a data-collection app for research purposes, patients find it of utmost importance that they can review their own data entries. Participants indicated that the app needs to improve its’ visual cues of when they need to perform certain activities. Take-away messages from the discussions about personalised gaming suite development: Smart games meant for disease management should be highly tailored to the capabilities of the patients. Gaming is for patients a way of relaxation, any game designed should not incorporate any stressful factors. Patient partners expressed interest in the proposed gaming categories. Future steps Future steps involve initiating a round of user testing for the PDPID version of the miPROLEPSIS app to validate designs with patients not involved in the development process. Subsequently, attention will shift to developing recommendation systems for physical activity and diet, incorporating insights from experts in the field (occupational therapists, physical therapists & nutritionists) and patients themselves. For the personalised gaming suite, the completion of the storyboard is planned for the end of December 2023, when the development of the first prototypes will follow. mIPROLEPSIS app.png mIPROLEPSIS app.png 1/1 PREVIOUS NEXT