< BACK iPROLEPSIS Plenary meeting Jun 23, 2023 iPROLEPSIS Consortium Partners Meet in Lisbon to Plan Next Steps The iPROLEPSIS consortium partners gathered in Lisbon, Portugal on June 20-21 for the 2nd Plenary meeting to review the progress and achievements of the project's work packages and plan the next steps. Over the course of two days, the consortium partners engaged in three productive workshops, each focusing on key aspects of the iPROLEPSIS project: Data Collection and Digital Biomarkers: The first workshop delved into the vital task of data collection and the development of digital biomarkers. Attendees discussed the identification of sensor and user data to be collected, including accelerometer/gyroscope data. Additionally, they explored algorithms for identifying inflammation drivers and defined user profiles to enhance personalized healthcare. System Architecture and Cloud Back-end: The second workshop centered around system architecture. The consortium partners discussed the key components of the system, including the orchestrator, and addressed critical aspects such as data management infrastructure and monitoring of app performance issues. miPROLEPSIS App and Serious Games: The third workshop involved a dynamic co-creation session, bringing together clinicians, patients, researchers, and developers. Focusing on the miPROLEPSIS app and serious games, participants explored various areas such as system architecture, key components, data management infrastructure, and app performance monitoring. The adoption of the "Crazy 8s" technique allowed for the rapid generation of a diverse range of ideas. During the third workshop patient representatives joined the session. Their valuable input and perspectives are crucial for understanding the specific needs and requirements of those who will benefit from our iPROLEPSIS project. By actively involving patient representatives, we can ensure that our solutions are truly patient-centric and tailored to their experiences and challenges. The iPROLEPSIS consortium is excited about the progress made during this meeting and is now equipped with a comprehensive plan for the next steps of the project. 3-1.jpg 3-1.jpg 1/1 PREVIOUS NEXT

< BACK Designing Exergames for Psoriatic Arthritis: The Spy and Zen Forest Paradigms Feb 4, 2026 New iPROLEPSIS publication presents the co-design of exergames to support physical activity and rehabilitation in psoriatic arthritis A new publication from the iPROLEPSIS project has been published in the proceedings of the 2025 IEEE International Conference on E-health Networking, Application & Services (HealthCom) . Psoriatic arthritis (PsA) is a rheumatic disease affecting the skin and joints and is commonly associated with stiffness, impaired mobility, and chronic pain. In addition to biological treatments, physiotherapy and exercise are often recommended to improve range of motion and physical function. However, low adherence, high costs, and limited engagement frequently reduce the effectiveness of these interventions. The paper presents the design of two exergames – The Spy and Zen Forest – developed as accessible digital tools to complement traditional rehabilitation approaches. Exergames embed therapeutic movements into game mechanics, supporting motivation and consistency in physical activity. Both games were co-designed with 29 experts , including patients with psoriatic arthritis, clinicians, researchers, and technical stakeholders, to ensure alignment with clinical goals, patient needs, and safe physical engagement. In The Spy , players complete physically engaging missions designed to stimulate dynamic body movement and support coordination, mobility, balance, strength, and flexibility. Zen Forest focuses on slow, calm stretching routines inspired by Pilates and Yoga, promoting flexibility, relaxation, and body awareness. Together, the exergames aim to support personalised activity routines and enable clinicians to monitor progress and recommend tailored interventions. Read the full publication: https://zenodo.org/records/18468928 iPROLEPSIS_Zen and Spy.png iPROLEPSIS_Zen and Spy.png 1/1 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search RSS News Feed Psoriatic Arthritis articles within Nature Reviews Rheumatology Journal of Psoriasis and Psoriatic Arthritis National Psoriasis Foundation

< BACK iPROLEPSIS Games Presented at the Pitch Competition during PhD Open Days Nov 7, 2024 Showcasing iPROLEPSIS Games at the PhD Open Days Pitch Competition On November 5th, Bárbara Ramalho from FMH/IST-ULisboa had the opportunity to present the iPROLEPSIS Games at the Pitch Competition during the PhD Open Days event at the Técnico Innovation Center . In her pitch, Bárbara highlighted the role of serious games in the iPROLEPSIS project, which aims to improve the care and management of psoriatic arthritis (PsA) through a personalised, game-based digital ecosystem. The PhD Open Days gave over a thousand students the chance to connect, network, and showcase their research to the academic community, industry professionals, and alumni. The Pitch Competition was a great opportunity for researchers to present their work and meet potential collaborators. 1/5 PREVIOUS NEXT

< BACK Trustworthy AI in Digital Health: The iPROLEPSIS Approach Mar 28, 2025 iPROLEPSIS at Health Data Summit 2025 At Health Data Summit 2025 , organised by The European Institute for Innovation Through Health Data on March 18–19 in Brussels , Vasileios Charisis, PhD , from the Signal Processing & Biomedical Technology Unit - AUTH , presented iPROLEPSIS during the session “Trustworthy AI in Digital Health: From Guidelines to Practice”. The presentation outlined the methodology used in iPROLEPSIS to develop a trustworthy AI (TAI) framework tailored to the project’s specific needs. A case study on the Lifestyle Recommendation Engine demonstrated how it aligns with TAI principles and recommendations . The session also featured other Horizon Europe projects , including AI-PROGNOSIS, TRUSTroke, and STRATIFYHF , which presented their approaches to developing trustworthy digital health solutions . By bringing together different initiatives, the session highlighted the importance of trustworthy AI in healthcare , ensuring transparency, reliability, and ethical considerations in digital health innovations . 1/3 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Handbook Learning hub Key Facts Handbook News Feed Quizzes Search Handbook 1 Psoriatic Arthritis Handbook Understanding Psoriatic Arthritis h1.1 What is psoriatic arthritis? Psoriatic arthritis is a type of arthritis linked with psoriasis, a chronic skin and nail disease. Psoriasis causes red, scaly rashes and thick, pitted fingernails. Psoriatic arthritis is characterized by joint swelling (inflammation), pain and stiffness and can affect any peripheral joint such as fingers, toes, knees and/or spine. It also affects the insertion of tendons or ligaments in bones (enthesitis). Between 20-40% of people with the skin condition psoriasis will develop psoriatic arthritis (1, 2). Symptoms affecting their joints tend to develop 5 to 10 years after psoriasis is diagnosed but it can occur at any time (3). Currently, it is not clear why some people with psoriasis develop psoriatic arthritis while others do not. The arthritis of psoriatic arthritis comes in 3 forms: oligoarticular arthritis that affects 4 or less peripheral joints (e.g., joints in the fingers, toes, knees); polyarticular arthritis that involves 5 or more peripheral joints on both sides of the body; and axial arthritis that affects the joints of the spine including the sacroiliac joint (where the spine connects to the pelvis). Some people may develop psoriasis after or at the same time as symptoms of psoriatic arthritis present themselves (4). In rare cases, people may have psoriatic arthritis and never have any noticeable symptoms of psoriasis. Psoriatic arthritis and psoriasis are chronic inflammatory conditions that are caused by a fault in the immune system. Our immune system protects us from infection and illness. See related Key Facts section What causes psoriatic arthritis? While psoriatic arthritis can occur at any age, most people present their first signs and symptoms at 30-50 years. Psoriatic arthritis is most likely to be diagnosed within the first ten years of the psoriasis diagnosis (3). Psoriatic arthritis affects both sexes equally. However, the manifestations in terms of severity and impact of the disease differ between sexes. Men are more likely to have involvement of the bones in the spine (axial arthritis) and radiographic damage in the spine and peripheral joints (e.g., fingers, knees and toes), whereas women are more likely to experience impaired quality of life and severe limitations in function (5). Researchers are not sure why some people develop psoriatic arthritis. It is thought that certain genes inherited from parents and grandparents can make a person more likely to develop psoriatic arthritis (6–8). h1.2 In people with a higher genetic predisposition to develop psoriatic arthritis, the condition can be triggered by environmental factors, such as: an infection (9); an accident or injury (10, 11); being overweight (12); smoking (13, 14). Psoriasis and psoriatic arthritis are not contagious. You cannot catch psoriasis or psoriatic arthritis from other people. See related Key Facts section What are the symptoms of psoriatic arthritis? Psoriatic arthritis symptoms usually develop slowly, that is, many people are unaware that they are developing psoriatic arthritis (Figure 1). Although symptoms can develop suddenly in rarer cases. Some of the main symptoms include (15): pain in one or more joints; swelling in one or more joints; stiffness in one or more joints that lasts for 30 minutes or longer. These symptoms are caused by inflammation and can affect any joint in the body. See Figure 2 for the most commonly affected joints. See related Key Facts section h1.3 Psoriatic arthritis can cause pain and swelling in the entheses, that is, places in the body where tendons and ligaments connect to the bones (15). When the entheses become inflamed it is known as enthesitis. Enthesitis pain can spread along a wider area than joint pain. It frequently occurs at the back of the heel or on the bottom of the foot, which can make standing or walking difficult. Affected areas feel tender to touch even when just a small amount of pressure is applied. The knees, hips, elbows and chest can also be affected by enthesitis. Many people with psoriatic arthritis have swollen fingers or toes, a condition that is known as dactylitis (15) (Figure 1). It most commonly affects one or two fingers or toes at a time. Psoriatic arthritis can also cause small round dents in fingernails and/or toenails, a condition known as pitting. The nails can change colour, become thicker, or even lift away from your finger (15). People living with psoriatic arthritis may feel very tired (fatigued) and some may have a low-grade fever. Fatigue does not get better with rest. Psoriatic arthritis symptoms may come and go. A period of increased inflammation and worsening of other symptoms is called a flare. A flare can last for days or months See related Key Facts section h1.5 How is psoriatic arthritis diagnosed? A timely and accurate diagnosis is an important step for optimising care and improve long-term health outcomes (16). If you have been diagnosed with psoriasis in the past, and symptoms of arthritis (e.g., painful or swollen joints) have started more recently, you may have developed psoriatic arthritis. However, the symptoms of psoriatic arthritis can look like other health conditions. Make sure to see your healthcare provider for a diagnosis. The doctor you see first may depend on whether you have previously been diagnosed with psoriasis. If you develop symptoms of arthritis your primary care or skin doctor should refer you to a rheumatologist – a doctor who specialises in joint conditions – for an assessment. Tell your doctor if you have a history of psoriasis and/or psoriatic arthritis in your family. CURRENTLY, NO SINGLE TEST CAN CONFIRM PSORIATIC ARTHRITIS (15). A diagnosis will be made based on your medical history, symptoms, and a physical examination by your doctor. Your doctor may order X-rays or other types of imaging, such as ultrasound scans and magnetic resonance imaging (MRI), to look for changes to your bones and joints. Imaging studies will help your doctor determine the type and pattern of joint involvement, which can also help them distinguish between arthritis types. Blood tests, such as erythrocyte sedimentation rate and C-reactive protein, can help to identify inflammation. Your doctor may also order tests for rheumatoid factor and the anti-CCP antibody to rule out rheumatoid arthritis and HLA-B types to look for your genetic predisposition to spondylarthritis. See related Key Facts section h1.4 See related Key Facts Previous page Next page

Meet our people Meet the people behind the iPROLEPSIS project. Coordination About team Software development About team Clinical experts About team Ethics, legal and exploitation About team Data sience About team Dissemination and communication About team

< BACK The Spy and Zen Forest Exergames as Sources of Digital Biomarkers for Psoriatic Arthritis: A Co-Design Paradigm Aug 24, 2026 New iPROLEPSIS publication presents co-designed exergames to support therapeutic engagement in psoriatic arthritis A new iPROLEPSIS publication presents two exergames co-designed with patients and clinicians to support therapeutic engagement in psoriatic arthritis care. The study introduces The Spy and Zen Forest , exergames that embed therapeutic movements into game mechanics. Psoriatic arthritis requires ongoing physiotherapy and exercise for joint health, but traditional approaches face challenges: patients experience low consistency in participation, high costs, and high dropout rates. The research involved co-design with 29 participants, including patients diagnosed with psoriatic arthritis, clinicians, researchers, and technical experts. This collaborative approach ensured the games align with clinical goals, address patient needs, and support safe and effective rehabilitation. In The Spy, players assume the role of a secret agent completing missions that require dynamic full-body movements targeting coordination, mobility, balance, strength, and flexibility. Zen Forest emphasizes slow, controlled movements inspired by Pilates and yoga, designed to improve flexibility, relaxation, and body awareness. The publication explores how exergames can serve as sources of digital biomarkers – measurable data collected through gameplay including movement quality, repetition patterns, and task performance – that may help researchers monitor patient progress and disease patterns. Read the full publication: https://ieeexplore.ieee.org/document/11552850 iPROLEPSIS_The Spy and Zen publication.png iPROLEPSIS_The Spy and Zen publication.png 1/1 PREVIOUS NEXT

< BACK Calling for Influencers: Join iPROLEPSIS as an Ambassador for Psoriatic Arthritis Feb 27, 2024 Join the iPROLEPSIS Initiative: Become an Ambassador for the iPROLEPSIS Project Join the iPROLEPSIS initiative! Calling all influencers, psoriatic arthritis warriors and health advocates to become iPROLEPSIS Ambassadors ! Our mission is to shed light upon the health-to-PsA transition through groundbreaking AI-driven analysis and cutting-edge technology. We are creating a digital health ecosystem for personalised psoriatic arthritis risk prediction and management. Are you passionate about health advocacy and psoriatic arthritis awareness? Become an iPROLEPSIS Ambassador and be a part of the change! Here is how you can make a difference as an iPROLEPSIS Ambassador: Promote the iPROLEPSIS mission Share iPROLEPSIS updates and developments Share personal stories and insights Ready to be a part of the change? Contact us at info@iprolepsis.eu , and we will provide you with more details. * Please note that this is voluntary, and no monetary compensation is offered. AI-PROGNOSIS events (8).png AI-PROGNOSIS events (8).png 1/1 PREVIOUS NEXT

Software development team Francisco Cardoso PLUX Position Software Developer What is your role in iPROLEPSIS? Monitoring Engineer What are your main activities in the project? I define SLIs/SLOs, design telemetry (metrics, logs, traces), build alerts and dashboards, run incident response/postmortems, and align data retention and security with compliance. What is your motivation? I’m motivated by making complex systems trustworthy. Turning real-time signals into fast decisions that reduce downtime and protect participants and data. Hugo Humberto Plácido da Silva PLUX Position Founder & Chief Innovation Officer What is your role in iPROLEPSIS? Principal Investigator representing PLUX. What are your main activities in the project? Internal management of the project at the board/administration level. Our team is making substantial contributions to the development of digital biomarkers (dBMs) that can be acquired using a smart belt. Furthermore, we are responsible for the iPROLEPSIS system orchestration, verification, and monitoring. What is your motivation? Psoriatic Arthritis (PsA) is a highly conditioning disease that currently affects a significant number of patients globally. Existing assessment and management methods are mostly bound to a clinical setting, involving complex protocols, therefore only of limited access to patients. For as long as I can remember, my work has been centered around purpose-driven innovations in the healthcare space; the possibility to explore novel dBMs as a way of improving the lives of PsA patients constitutes a once-in-a-lifetime opportunity and purpose like none other. Sofia Balula Dias Faculdade de Motricidade Humana Position Principal Investigator representing FMH partner What is your role in iPROLEPSIS? As Principal Investigator, I lead the design and development of a serious games-based intervention tool specifically tailored to support individuals living with Psoriatic Arthritis. What are your main activities in the project? Our multidisciplinary team is leading the development of the iPROLEPSIS serious games application to support Psoriatic Arthritis patients. Through co-creation with patients and collaboration across research, clinical, and design fields, we’re tailoring game mechanics and biofeedback features to meet real needs and preferences. Our work involves prototyping, testing, and refining therapeutic content designed to improve mobility, support pain management, reduce stress, and promote self-management, ultimately contributing to a more holistic and patient-centered approach to chronic care. What is your motivation? I am driven by the opportunity to improve the lives of PsA patients through non-pharmacological, technology-driven interventions. Serious games present an innovative and empowering method for symptom management and patient engagement. To date, there are no serious games specifically tailored to the needs of individuals with PsA, making this work both timely and impactful. Rodrigo Duarte Braga PLUX Position Research Collaborator What is your role in iPROLEPSIS? Systems Engineer What are your main activities in the project? I coordinate system orchestration, verification, and monitoring. I also lead the Smartbelt's technical development, from data acquisition and processing device data to building machine learning models. What is your motivation? Tackling complex challenges and developing innovative solutions and medical devices that create tangible value. Sérgio Lopes da Fonseca PLUX Position Project Manager What is your role in iPROLEPSIS? PLUX’s contribution to iPROLEPSIS management. What are your main activities in the project? Aligning timelines, deliverables, and resources across partners. I manage work-package commitments, budget and risks, and represent PLUX in steering and technical meetings to keep decisions action-oriented and on schedule. What is your motivation? To turn research into deployable, user-centred solutions. I’m driven by projects that measurably improve clinical workflows and patient outcomes—while creating a clear path from prototype to scalable product. iPROLEPSIS is a chance to do all three: integrate wearable biosignals seamlessly, prove value in real settings, and accelerate European med-tech competitiveness. Coordination Clinical Experts Data Science Software Development Ethics, Legal and Exploitation Dissemination and Communication

< BACK iPROLEPSIS Newsletter No. 12 Jul 22, 2026 Latest news from iPROLEPSIS Welcome to the twelfth edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter_Jul 2026_ Issue No. 12 .pdf Download PDF • 5.24MB iPROLEPSIS_newsletter 12.png iPROLEPSIS_newsletter 12.png 1/1 PREVIOUS NEXT

The consortium of iProlepsis project for psoriatic arthritis consists of 15 partners from 9 countries. Discover more about project by visiting our website. About consortium partners iPROLEPSIS project coordinator Aristotle University of Thessaloniki Consortium consists of 15 partners from 9 countries. iPROLEPSIS consortium partners