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< BACK iPROLEPSIS Newsletter No. 5 Jul 10, 2024 Discover Insights from Clinicians, Collaborative Efforts, and Key Events Welcome to the fifth edition of the iPROLEPSIS project newsletter. In this issue, we bring you insightful interviews with clinicians specialising in psoriatic arthritis, insights into recent clustering and networking activities, and reflections on key past events. iPROLEPSIS_Newsletter No. 5 .pdf Download PDF • 8.01MB 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Presented at the 7th Panhellenic Multidisciplinary Congress of Autoimmune Diseases, Rheumatology & Clinical Immunology Apr 7, 2025 Engaging the clinical community with updates on iPROLEPSIS and ongoing research From 28–30 March 2025, the 7th Panhellenic Multidisciplinary Congress of Autoimmune Diseases, Rheumatology & Clinical Immunology took place in Portaria, Greece. Maria Mytilinaiou , representing the Aristotle University of Thessaloniki (AUTH) , presented an overview of the iPROLEPSIS and HIPPOCRATES projects and ongoing clinical studies. The congress brought together clinicians and researchers from across Greece, offering a valuable opportunity to share insights and strengthen collaboration. 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS Lifestyle Recommendation Engine Co-Creation Insights Nov 12, 2024 User-Centered Development of the iPROLEPSIS Lifestyle Recommendation Engine The iPROLEPSIS project recently hosted its first co-creation session focused on refining the Lifestyle Recommendation Engine for individuals with Psoriatic Arthritis (PsA). This online session brought together a diverse, multidisciplinary group of 20 participants, including patient research partners from Portugal, The Netherlands, the UK, and Greece, along with clinicians, researchers, and developers from the iPROLEPSIS consortium. During the session, participants explored mockups and initial prototypes for nutrition and physical activity recommendations, offering valuable insights that guide iterative development towards a more user-centred and impactful design for the iPROLEPSIS Lifestyle Recommendation Engine. Purpose and Approach This collaborative effort aimed to improve the iPROLEPSIS Lifestyle Recommendation Engine, ensuring that it is user-centred and impactful. The session included detailed presentations of mockups and prototypes, followed by discussions where participants shared their perspectives and feedback on the nutrition and physical activity guidelines. Key Findings Strengths Clear Presentation: Participants appreciated the clarity of the nutrition and exercise recommendations, especially the structured breakdown of weekly meal plans and exercise intensity levels, which allowed for easy tailoring to user capabilities. User-Friendly Exercise Recommendations: Including exercise intensity was highly valued, helping users to select routines suitable to their abilities. Areas for Improvement Portion Sizes and Meal Timings : Participants recommended clearer definitions for portion sizes and specific guidance on meal timings to better support daily routines. Household Measurements : To improve accessibility, participants suggested including household measurements for ingredients, making recipes easier to follow. Cultural and Dietary Preferences : The inclusion of various cuisines, dietary options (e.g., vegetarian, gluten-free), and meal preparation cost considerations were recommended. Suggestions for Future Development Customizable Meal Plans : Participants supported options for users to create or choose from curated meal plans, along with suggested recipes for variety and personalisation. Enhanced Accessibility in Physical Activity : The need for exercise recommendations catering to different mobility levels was emphasised, with suggestions for low-intensity options for users with limited physical capacity. Safety Information and Usability : Feedback supported the inclusion of safety information for users with joint conditions and clarity enhancements in the app's design, particularly in colour-coding for specific goals. Interactive Goal Setting : Participants supported the inclusion of features for progress tracking and personalised goal setting to motivate users and enhance engagement. Participant Feedback and Satisfaction Participants expressed high satisfaction, particularly with the session’s structure and the collaborative nature of the discussion. Many appreciated the online format, which improved interaction. Looking Ahead The valuable feedback gathered will guide further development, ensuring the Lifestyle Recommendation Engine meets diverse user needs. Future iterations will aim to incorporate additional user-friendly features, making it easier for individuals with PsA to access personalised nutrition and physical activity recommendations tailored to their unique health goals and lifestyle preferences. 1/3 PREVIOUS NEXT

< BACK Patty de Groot Discusses Digital Biomarkers in Rheumatology Podcast Jan 10, 2025 Exploring the Future of Digital Biomarkers in Rheumatology Patty de Groot from Erasmus MC recently appeared on the Digital Rheumatology Network podcast on Spotify, where she shared her insights on the role of digital biomarkers in rheumatology care. In this engaging conversation, Patty discusses the potential of digital tools, including findings from the iPROLEPSIS project, to improve early diagnosis, personalise treatment, and enhance patient care. She also talks about the use of design-thinking approaches to optimise healthcare workflows and the challenges of integrating digital innovations in clinical practice. Listen to the full podcast episode to learn more about how digital biomarkers are transforming rheumatology care and the future of healthcare innovation. 🎧 Listen here 1/1 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search What are the symptoms of psoriatic arthritis? See related Handbook section PREVIOUS NEXT

< BACK iPROLEPSIS Presented at Health Data Summit 2025 Mar 27, 2025 Showcasing practical strategies for high-quality data mapping and harmonisation At Health Data Summit 2025 , organised by the European Institute for Innovation Through Health Data (i~HD) on March 18–19 in Brussels , the iPROLEPSIS project was presented by Thanos Vidakis from AINIGMA Technologies . The presentation was part of the session titled: "Advanced Strategies and Tools for Ensuring High-Quality Data During Data Mapping". It focused on how iPROLEPSIS uses the OMOP Common Data Model (CDM) and OHDSI tools to harmonize health datasets from various sources. By applying coding standards such as SNOMED , the project ensures consistency and interoperability across data systems. The talk also highlighted recent hands-on workshops with data experts , during which real-world data was mapped to the OMOP model and underwent quality checks . These steps are essential in delivering analytics-ready health data — a key goal of the project. iPROLEPSIS continues to support high standards in digital health research by promoting data quality, standardisation, and collaboration across partners. 1/2 PREVIOUS NEXT

< BACK Europe Day 2024 May 9, 2024 Celebrating Europe Day with iPROLEPSIS sister projects Happy Europe Day 2024! Today we celebrate unity in diversity, innovation and collaboration across the continent. As projects funded under the same Horizon Europe call topic: "Personalised blueprint of chronic inflammation in health-to-disease transition", we're proud to contribute to the common goals of understanding the risk factors that trigger the transition from health to disease, providing personalised prevention measures and reducing the burden of chronic diseases. Within iPROLEPSIS , we aim to develop a suite of digital health tools designed to detect early transitions to psoriatic arthritis, predict flares for timely intervention, and provide personalised recommendations and interventions for managing the disease. With our unique consortium of 15 partners from 9 countries, we are strengthening international and cross-border collaboration to advance research, technology and health progress in Europe and beyond. Join us in commemorating this special day by exploring the impactful work of our sister projects: GlycanTrigger , ENDOTARGET , IMMEDIATE , miGut-Health , AIDA EU project , PREVALUNG EU , PRAESIIDIUM , CARE-IN-HEALTH , Intercept-T2D , INITIALISE , Halt-RONIN , Together, we're shaping a brighter, more inclusive, and sustainable Europe through groundbreaking research and cross-border connections. Europe Day sister projects .png Europe Day sister projects .png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Games Showcased at Lisboa Games Week 2025 Nov 24, 2025 The FMH/IST-ULisboa team presented the iPROLEPSIS Games, connecting with the gaming community and industry stakeholders The iPROLEPSIS Games were presented at Lisboa Games Week 2025 , held from 20–23 November in Portugal. The team from Faculdade de Motricidade Humana / Instituto Superior Técnico – ULisboa (Bárbara Ramalho, Samuel Gomes, Marta Vicente, Filipa Magalhães and Rodolfo Costa) showcased the serious games developed within the project. Lisboa Games Week is an event that reinforces the role of academic and professional training in the video game industry. Educational institutions present courses, projects, and programmes related to video game development, digital art, programming, design, animation, sound, virtual reality, artificial intelligence, and other technological and creative fields. The programme includes exhibitions, practical demonstrations, vocational guidance sessions, talks, and opportunities for direct contact with industry. Participation in this event provided a platform for presenting the iPROLEPSIS Games within a setting focused on education, creativity, and technological development. 🔗 https://lisboagamesweek.pt/ LGWPhoto4.jpeg LGWPhoto3.jpeg LGWPhoto3.jpeg LGWPhoto4.jpeg 1/4 PREVIOUS NEXT

< BACK Workshop at PETRA 2024: Advancing Personalised Health Through Multimodal Sensing and Innovative Environments Jan 25, 2024 Exploring the Future of Healthcare: AI-PROGNOSIS and iPROLEPSIS Projects Collaborate for Workshop on Human Health, Habits, and Behavior The workshop "AGENT - MultimodAl SiGnal Sensing/Analysis, Innovative Interactive Environments, and PersoNalized Behavioral Modeling for Improving QualiTy-of-Life" has been accepted in PETRA 2024! The workshop will be organised by the Centre for Research & Technology Hellas , Aristotle University of Thessaloniki , and Faculdade de Motricidade Humana in cooperation with the AI-PROGNOSIS and iPROLEPSIS projects. More info about the workshop: http://www.petrae.org/workshops/AGENT.html AI-PROGNOSIS is a Horizon Europe-funded project developing Artificial intelligence-based solutions for #Parkinson 's disease risk assessment and prognosis. iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with #Psoriatic #arthritis . The workshop aims to attract an interdisciplinary group of researchers involved in research related to early detection, assessment and monitoring of human health, habits and behaviour. The workshop will focus on novel technologies applied in real or virtual environments and aim to enhance the quality of daily living, especially for people with disabilities or patients suffering from chronic conditions. About PETRA 2024: PETRA (PErvasive Technologies Related to Assistive Environments) is a premier interdisciplinary conference focusing on computational and engineering approaches to enhance human performance and improve the quality of life. Join us in exploring the latest advancements in assistive technologies across various settings. More info: http://www.petrae.org/index.html Looking forward to an enriching exchange of ideas and knowledge at PETRA 2024! Banner1-2024.png Banner1-2024.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Project Presented to Sonova International Sep 10, 2024 Innovative Approaches in Digital Biomarkers In September 2024, the iPROLEPSIS project was presented at a meeting with Sonova International. This event included a series of insightful presentations, highlighting the project's focus on developing digital biomarkers. The iPROLEPSIS concept and vision were shared, showcasing the innovative approaches the project is undertaking. We extend our gratitude for the engaging discussions during the “Sonova-AUTH Day,” hosted by the Signal Processing & Biomedical Technology Unit at Aristotle University of Thessaloniki. The event featured a range of topics, including advancements in digital biomarkers, innovations in hearing instruments by Sonova Group, ear-EEG technology, auditory processing disorders, and insights into the hearing aid market in Greece. 1/2 PREVIOUS NEXT

< BACK iPROLEPSIS presented at the 2024 HIMSS European Health Conference Jun 11, 2024 Showcasing AI-Based Solutions for Psoriatic Arthritis Care Our project partner, PLUX Biosignals , participated in the 2024 HIMSS European Health Conference and Exhibition , where they showcased the innovative work of the iPROLEPSIS project, developing a novel personalised digital care ecosystem for people with psoriatic arthritis. The 2024 HIMSS European Health Conference and Exhibition was a major event for the European digital health community, bringing together approximately 2,500 healthcare executives, practitioners and professionals from 84 different countries in Rome. Held from May 29 to 31, the conference showcased the latest advancements in healthcare technology and provided a platform for critical discussions on the future of digital health in Europe and worldwide. HIMSS24 Europe addressed the region’s strategic initiatives in digital health, including the AI Act and the European Health Data Space, which aim to position Europe as a leader in digital health. HIMSS_iPROLEPSIS (2).jpg HIMSS_iPROLEPSIS (1).jpg HIMSS_iPROLEPSIS (2).jpg 1/2 PREVIOUS NEXT

< BACK State-of-the-art analysis and datasets landscape Nov 6, 2023 Initial review, focusing on the state-of-the-art literature and existing datasets in the field of PsA Psoriatic arthritis is a chronic immune-mediated inflammatory arthritis occurring in patients with PsO. The disease manifestation can be heterogeneous between subjects, and the resulting musculoskeletal impairment can interfere with physical function as well as the quality of life of patients. In a collaborative effort, the iPROLEPSIS partners completed an initial extensive review, focusing on the state-of-the-art literature and existing datasets in the field of PsA, with a special focus on flare dynamics. The primary goal was to enhance the understanding of PsA by investigating disease symptoms, factors associated with flares, and markers for disease development and monitoring. The insights gained from the literature will provide background for various aspects of iPROLEPSIS research, such as investigating PsA inflammation drivers and monitoring, developing the iPROLEPSIS digital health ecosystem for personalised preventive care, and conducting clinical studies. Moreover, various multi-source datasets have been identified that can potentially yield valuable information for the discovery of PsA inflammation drivers and the development of novel digital biomarkers and predictive models for disease monitoring and progression prognosis. The identified datasets will be assessed for relevancy and usability, retrieved, harmonised and curated. These datasets and predictive models will contribute to the research on PsA monitoring and inflammation drivers. In addition, the identified existing datasets will also guide the development of the Lifestyle AI-driven recommendation system and the Serious Games. The key takeaways are: Fatigue, pain and stiffness are commonly reported symptoms in PsA Flare may be triggered by alterations in mood, stress, sleep, bowel movements, and environmental factors Flare may affect mood, stress, sleep, bowel movements, physical activity and fine motor skills Certain symptoms of PsA may also trigger or be triggered by flare Clinical measurements of PsA symptoms and hypothesized flare associated factors, mainly include questionnaires The use of smartphone and wearables to monitor physical activity (mainly through accelerometer data), fine motor skills (through keystroke dynamics), heart rate, heart rate variability have also shown potential to measure PsA symptoms and hypothesized flare associated factors Electrography techniques can also be used in the assessment of certain symptoms and flare associated factors Genetic factors may contribute to development of PsA, pain perception and response to treatment. Gut microbiome may be involved in PsA. MCs in skin are suggested to play a role in skin inflammation Monitoring of PsA can be achieved through clinical examination for inflamed joints, enthesitis dactylitis, nail and skin and subsequent calculation of relative indices and composite scores Imaging-based approaches including images obtained from smartphones and optoacoustics represent a complementary or alternative approach to clinical assessment Data-driven models can serve to find predictive relations even when the underlying mechanisms are poorly understood or are too complex. Recommendations and SGs present a potential approach to modify and improve diet and physical activity Besides diet and physical activity, SGs can also address other aspects of disease, including medication adherence, social support, cognition, breathing, biological and neural function OMOP CDM was opted to be used for standardising the datasets Future steps include an update on state-of-the-art literature and measurement tools on the topics covered by initial research and the identification of new datasets that could be relevant for data-driven models. News & Events iPROLEPSIS - news.png News & Events iPROLEPSIS - news.png 1/1 PREVIOUS NEXT