Oct 1, 2026
iPROLEPSIS investigates drivers of inflammation and factors associated with disease activity in psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. Patients with PsA can experience periods of increased disease activity, known as flares, but knowledge about the triggers of these flares remains limited.
Within iPROLEPSIS, research is being conducted to identify key drivers of inflammation in PsA through the analysis of retrospective datasets and prospective data from the Psoriatic Disease Patient Inflammation Drivers (PDPID) study.
Analysis of the DEPAR and Reuma.pt cohorts showed differences in disease activity, disease duration, phenotype and treatment. Differences between males and females were also observed across several PsA-related measures. The analysis further showed that early PsA diagnosis was associated with lower disease activity and better quality-of-life measures, while diagnosis timing alone did not determine treatment trajectory.
Preliminary analysis of PDPID baseline data from the Netherlands, UK and Greece found that flare was associated with higher pain, fatigue, sleep disturbance and stiffness. Higher perceived stress was associated with higher disease activity. Higher nitrogen dioxide (NO₂) exposure was associated with higher disease activity, while higher ozone (O₃) exposure was associated with lower disease activity.
The analysis will be expanded with more participants, follow-up data and additional clinical, biological and environmental data, including genetic and gut microbiome data.
Read the full report on Zenodo: https://zenodo.org/records/22655513
