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< BACK iPROLEPSIS Project Presented to Sonova International Sep 10, 2024 Innovative Approaches in Digital Biomarkers In September 2024, the iPROLEPSIS project was presented at a meeting with Sonova International. This event included a series of insightful presentations, highlighting the project's focus on developing digital biomarkers. The iPROLEPSIS concept and vision were shared, showcasing the innovative approaches the project is undertaking. We extend our gratitude for the engaging discussions during the “Sonova-AUTH Day,” hosted by the Signal Processing & Biomedical Technology Unit at Aristotle University of Thessaloniki. The event featured a range of topics, including advancements in digital biomarkers, innovations in hearing instruments by Sonova Group, ear-EEG technology, auditory processing disorders, and insights into the hearing aid market in Greece. 1/2 PREVIOUS NEXT

< BACK iPROLEPSIS presented at the 2024 HIMSS European Health Conference Jun 11, 2024 Showcasing AI-Based Solutions for Psoriatic Arthritis Care Our project partner, PLUX Biosignals , participated in the 2024 HIMSS European Health Conference and Exhibition , where they showcased the innovative work of the iPROLEPSIS project, developing a novel personalised digital care ecosystem for people with psoriatic arthritis. The 2024 HIMSS European Health Conference and Exhibition was a major event for the European digital health community, bringing together approximately 2,500 healthcare executives, practitioners and professionals from 84 different countries in Rome. Held from May 29 to 31, the conference showcased the latest advancements in healthcare technology and provided a platform for critical discussions on the future of digital health in Europe and worldwide. HIMSS24 Europe addressed the region’s strategic initiatives in digital health, including the AI Act and the European Health Data Space, which aim to position Europe as a leader in digital health. HIMSS_iPROLEPSIS (2).jpg HIMSS_iPROLEPSIS (1).jpg HIMSS_iPROLEPSIS (2).jpg 1/2 PREVIOUS NEXT

< BACK State-of-the-art analysis and datasets landscape Nov 6, 2023 Initial review, focusing on the state-of-the-art literature and existing datasets in the field of PsA Psoriatic arthritis is a chronic immune-mediated inflammatory arthritis occurring in patients with PsO. The disease manifestation can be heterogeneous between subjects, and the resulting musculoskeletal impairment can interfere with physical function as well as the quality of life of patients. In a collaborative effort, the iPROLEPSIS partners completed an initial extensive review, focusing on the state-of-the-art literature and existing datasets in the field of PsA, with a special focus on flare dynamics. The primary goal was to enhance the understanding of PsA by investigating disease symptoms, factors associated with flares, and markers for disease development and monitoring. The insights gained from the literature will provide background for various aspects of iPROLEPSIS research, such as investigating PsA inflammation drivers and monitoring, developing the iPROLEPSIS digital health ecosystem for personalised preventive care, and conducting clinical studies. Moreover, various multi-source datasets have been identified that can potentially yield valuable information for the discovery of PsA inflammation drivers and the development of novel digital biomarkers and predictive models for disease monitoring and progression prognosis. The identified datasets will be assessed for relevancy and usability, retrieved, harmonised and curated. These datasets and predictive models will contribute to the research on PsA monitoring and inflammation drivers. In addition, the identified existing datasets will also guide the development of the Lifestyle AI-driven recommendation system and the Serious Games. The key takeaways are: Fatigue, pain and stiffness are commonly reported symptoms in PsA Flare may be triggered by alterations in mood, stress, sleep, bowel movements, and environmental factors Flare may affect mood, stress, sleep, bowel movements, physical activity and fine motor skills Certain symptoms of PsA may also trigger or be triggered by flare Clinical measurements of PsA symptoms and hypothesized flare associated factors, mainly include questionnaires The use of smartphone and wearables to monitor physical activity (mainly through accelerometer data), fine motor skills (through keystroke dynamics), heart rate, heart rate variability have also shown potential to measure PsA symptoms and hypothesized flare associated factors Electrography techniques can also be used in the assessment of certain symptoms and flare associated factors Genetic factors may contribute to development of PsA, pain perception and response to treatment. Gut microbiome may be involved in PsA. MCs in skin are suggested to play a role in skin inflammation Monitoring of PsA can be achieved through clinical examination for inflamed joints, enthesitis dactylitis, nail and skin and subsequent calculation of relative indices and composite scores Imaging-based approaches including images obtained from smartphones and optoacoustics represent a complementary or alternative approach to clinical assessment Data-driven models can serve to find predictive relations even when the underlying mechanisms are poorly understood or are too complex. Recommendations and SGs present a potential approach to modify and improve diet and physical activity Besides diet and physical activity, SGs can also address other aspects of disease, including medication adherence, social support, cognition, breathing, biological and neural function OMOP CDM was opted to be used for standardising the datasets Future steps include an update on state-of-the-art literature and measurement tools on the topics covered by initial research and the identification of new datasets that could be relevant for data-driven models. News & Events iPROLEPSIS - news.png News & Events iPROLEPSIS - news.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Plenary meeting Jun 22, 2023 iPROLEPSIS Consortium Partners Meet in Lisbon to Plan Next Steps The iPROLEPSIS consortium partners gathered in Lisbon, Portugal on June 20-21 for the 2nd Plenary meeting to review the progress and achievements of the project's work packages and plan the next steps. Over the course of two days, the consortium partners engaged in three productive workshops, each focusing on key aspects of the iPROLEPSIS project: Data Collection and Digital Biomarkers: The first workshop delved into the vital task of data collection and the development of digital biomarkers. Attendees discussed the identification of sensor and user data to be collected, including accelerometer/gyroscope data. Additionally, they explored algorithms for identifying inflammation drivers and defined user profiles to enhance personalized healthcare. System Architecture and Cloud Back-end: The second workshop centered around system architecture. The consortium partners discussed the key components of the system, including the orchestrator, and addressed critical aspects such as data management infrastructure and monitoring of app performance issues. miPROLEPSIS App and Serious Games: The third workshop involved a dynamic co-creation session, bringing together clinicians, patients, researchers, and developers. Focusing on the miPROLEPSIS app and serious games, participants explored various areas such as system architecture, key components, data management infrastructure, and app performance monitoring. The adoption of the "Crazy 8s" technique allowed for the rapid generation of a diverse range of ideas. During the third workshop patient representatives joined the session. Their valuable input and perspectives are crucial for understanding the specific needs and requirements of those who will benefit from our iPROLEPSIS project. By actively involving patient representatives, we can ensure that our solutions are truly patient-centric and tailored to their experiences and challenges. The iPROLEPSIS consortium is excited about the progress made during this meeting and is now equipped with a comprehensive plan for the next steps of the project. 3-1.jpg 3-1.jpg 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Innovative Federated Learning Approach at IEEE IST 2023 Oct 23, 2023 Enhancing Federated Learning Through Advanced Weight Distribution Analysis IEEE International Conference on Imaging Systems and Techniques (IST) conference served as a platform for presenting iPROLEPSIS research in federated learning, specifically focusing on novel methods for weight aggregation. Title: Federated Learning Aggregation based on Weight Distribution Analysis Abstract: Federated learning has recently been proposed as a solution to the problem of using private or sensitive data for training a central deep model, without exchanging the local data. In federated learning, local models are trained on the client side using the available data, while a server is responsible for aggregating the weights of these models into a global model. However, the traditional weight averaging approach does not take into consideration the importance of the different weights for the performance of a model. To this end, this work proposes a novel federated learning weight aggregation method that estimates the statistical distance of each client's parameters from the Gaussianity, and weighs the contribution of each client to the global model accordingly so that the most significant information is retained and enhanced. To create an accurate global model, a complex weighted averaging of the parameters of clients' models at the layer level is performed, considering as low quality the parameters following the Gaussian distribution. The proposed method can be employed to both convolutional and linear layers and it is based on the notion that parameters following a Gaussian distribution do not significantly affect the output of a model. Experiments with different network architectures and a comparison with a plethora of state-of-the-art approaches on three well-known image classification datasets demonstrate the superiority of the proposed method for federated learning weight aggregation. Read the full publication here: (PDF) Federated Learning Aggregation based on Weight Distribution Analysis ( researchgate.net ) https://ieeexplore.ieee.org/document/10355708 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS at GRAPPA 2025: Advancing Digital Tools for Psoriatic Arthritis Care Jul 18, 2025 Exploring how digital biomarkers can support hand function assessment in real-world settings iPROLEPSIS participated in the GRAPPA Annual Meeting 2025 , held on 10–12 July in Bogotá, Colombia. Vasilis Charisis (Aristotle University of Thessaloniki – AUTH) presented an overview of the project’s key objectives and emerging results. The talk highlighted how digital biomarkers – captured via smartphone typing dynamics and video-based motor tasks – can support the assessment of hand function in real-world conditions. The session reached approximately 350 stakeholders, including clinicians, researchers, and industry representatives, helping raise awareness of iPROLEPSIS and its goals within the psoriatic disease community. 2.jpg 1.jpg 3.jpg 2.jpg 1/3 PREVIOUS NEXT

< BACK Advancing Psoriatic Arthritis: Rheumatologist Ilja Tchetverikov's Insights on iPROLEPSIS May 22, 2024 Exploring Innovative Approaches to Disease Management and Patient Care in Psoriatic Arthritis" Ilja Tchetverikov , a rheumatologist and project partner from the CICERO Foundation (the Netherlands), provides insights into the iPROLEPSIS project's endeavours. He emphasises the need for a deeper understanding of psoriatic arthritis , a chronic inflammatory condition impacting various body parts due to immune system disturbances. I. Tchetverikov highlights the project's focus on investigating disease progression factors and developing non-invasive measurement tools . “Everybody can measure anything, but then you have to know what you're measuring. The whole idea of the project is that we combine two strengths. One of them is providing and developing a technical solution on how to measure the disease activity. And from the other side, we are going to label the data coming in from the system, from the clinical point of view. So we will be able to say whether or not some people have a low or high level of disease activity. So it's one part of the investigation. The other part of the investigation is to see whether other factors, which are already known to influence the whole system of your human body, like stress factors and some, for instance, gut microbiome composition, can also change during the course of the disease and how they are influencing the course of the disease itself,” states Ilja Tchetverikov . Through a collaborative effort integrating clinical expertise and technical innovation, the project aims to assess disease activity levels and explore external factors accurately. iPROLEPSIS interview.png iPROLEPSIS interview.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Games Presented at HiTech Program in Lisbon Jun 27, 2025 FMH/IST-ULisboa team showcased the project’s serious games to investors and health innovation experts On June 26, 2025, the iPROLEPSIS Games were presented during the final pitch session of the HiTech Program , held at the Thalia Theater in Lisbon, Portugal. Representing FMH/IST-ULisboa , Samuel Gomes , Bárbara Ramalho , and Filipa Magalhães introduced the iPROLEPSIS Games to an audience of investors and stakeholders interested in supporting innovative health solutions. This opportunity marked an important step in sharing iPROLEPSIS tools with a wider innovation and investment community. Read more about HiTech program here: https://hiseedtech.com/programs#header HiTech.jpg HiTech.jpg 1/1 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search How is psoriatic arthritis treated? Drug treatments See related Handbook section PREVIOUS NEXT

< BACK iPROLEPSIS Newsletter No. 8 Apr 28, 2025 Latest News from iPROLEPSIS Welcome to the eighth edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter Issue No. 8_Apr 2025 .pdf Download PDF • 3.38MB 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Kick-Off Meeting Jan 8, 2023 iPROLEPSIS, a four-year Horizon Europe project on AI-enabled Psoriatic Arthritis screening, monitoring, and care, kicked off. iPROLEPSIS, a four-year H orizon Europe project on AI-enabled Psoriatic Arthritis screening, monitoring, and care, kicked off. Our consortium partners met in Thessaloniki, Greece, and during a two-day event laid the groundwork for this exciting research and innovation venture. The focus was placed on the four clinical studies that will be conducted in the project. News & Events iPROLEPSIS.png News & Events iPROLEPSIS.png 1/1 PREVIOUS NEXT

< BACK Highlights from PETRA 2024 Jul 1, 2024 The iPROLEPSIS Exergames Introduced at PETRA 2024 The iPROLEPSIS Exergames were introduced and received very positively by the audience at PETRA 2024, a scientific interdisciplinary conference held on 26-28 June 2024 in Crete, Greece. Developing Exergames for Psoriatic Arthritis using Agile Storyboarding and Game Design Processes Abstract: Serious Games (SGs) offer significant potential in healthcare for disease assessment and intervention, enhancing patients’ quality of life. Exercise SGs, or Exergames, promote physical activity and mobility in a gamified environment, encouraging tailored exercises based on individual abilities and needs. Here, within the Horizon Europe iPROLEPSIS project that targets Psoriatic Arthritis (PsA), we describe the design process of Exergames to address PsA symptoms, including morning stiffness, impaired finger/hand and wrist functionality, and motor asymmetry. From a methodological point of view, the storyboarding technique was adopted to facilitate the visualization of the proposed Exergame scenarios, including the graphical user interface, interactive game elements, narratives, characters, and contexts related to the PsA condition. This approach has been implemented within an agile game development methodology, which includes gathering feedback early on to iteratively refine both the game ideas and prototype. Informed by the results of the game design via two agile sessions incorporating 25 participants (PsA patients, clinicians, technology developers, facilitators/observers), the current efforts are focused on developing the game prototypes and corresponding mock-ups, preparing them for upcoming clinical validation trials. The Exergames development lays the groundwork for an innovative framework to improve gross and fine motor symptoms in PsA patients. This framework could inform healthcare providers and policymakers about its potential inclusion in routine PsA management. Read the full publication: https://dl.acm.org/doi/10.1145/3652037.3663939 1/3 PREVIOUS NEXT