< BACK iPROLEPSIS at SportEx during ECSS 2026 Aug 18, 2026 Connecting iPROLEPSIS with the sport science community The European Conference of Sports Science (ECSS) 2026 took place in Lausanne, Switzerland, from 7 to 10 July 2026. As part of the event, SportEx , the official exhibition of ECSS, brought together companies from around the world to showcase innovations in sport science, including wearable technologies, physiological measurement systems, biomechanics, and software solutions. iPROLEPSIS was represented at SportEx by project partner PLUX. This participation helped increase the project’s visibility within the wider sport science community and among stakeholders interested in innovative technologies and digital health. PLUX also showcased its work in biosignal acquisition and wearable technologies, areas closely related to the development of innovative digital health solutions within iPROLEPSIS. IProlepsis 2.jpeg Conference overview 2.jpg Booth 3.jpeg IProlepsis 2.jpeg 1/3 PREVIOUS NEXT

< BACK iPROLEPSIS at IEEE EMBC 2026 Aug 26, 2026 Representing iPROLEPSIS at an international biomedical engineering conference The 48th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2026) took place in Toronto, Canada, from 26 to 30 July 2026. The conference focused on “Engineering Sustainable and Equitable Healthcare” and brought together academics, medical professionals, and industry experts working in biomedical engineering and healthcare. iPROLEPSIS was represented at the conference by project partner PLUX. PLUX used the event to highlight current research initiatives and present its latest developments in biosignal measurement systems, wearable technology, and analytical software. The participation also provided opportunities for networking, exchange with specialists, and gathering feedback relevant to future development and research projects. iProlepsis_2_EMBS.jpeg iProlepsis_EMBS.jpeg iProlepsis_2_EMBS.jpeg 1/2 PREVIOUS NEXT

The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalized digital care ecosystem. iPROLEPSIS is a s olution for psoriatic arthritis The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalised digital care ecosystem. LEARNING HUB PROJECT NEWS Psoriatic Arthritis (PsA) is a chronic progressive inflammatory disease affecting 1-2% of the general population, while manifesting in up to 30% of people with psoriasis (PsO). Project vision and impact iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with PsA. The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real World Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. DISCOVER MORE Project objectives and work packages iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA) and has 6 Work Packages of the project that will bring together various and complementary expertise from consortium partners. DISCOVER MORE About project 15 Partners 9 Countries 48 m Project duration € 6,4M Total budget The core activity domains Establishment • The foundation for the project’s research activities is laid by means of an extensive exploration of the available literature and data and the design of the clinical data collection and validation studies; • Participatory design supporting the development of a user-oriented ecosystem of solutions will be employed to establish a framework for trustworthy AI-based R&D. Validation • The design and implementation of the clinical studies that will collect research data, validate the inflammatory symptoms digital biomarkers in individuals at risk of PsA and PSO patients, and evaluate the efficacy of the digital care tools with respect to prevention of inflammation exacerbation. Research and development • Research on multimodal data to reveal key PsA inflammation drivers, provide digital biomarkers of PsA inflammatory symptoms, and explore the effect of PsA on the joints and skin microvasculature, as well as the role of mast cells in PsA transition; • Synthesise the outcomes into a multiscale/multifactorial model of the health-to-PsA transition; • Deliver the integrated iPROLEPSIS digital health ecosystem comprising tools for personalised preventive PsA care, to empower patients and HCPs. Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Handbook Handbook 2 Psoriatic Arthritis Key Facts Key Facts Psoriatic Arthritis Handbook Handbook Quizzes about Psoriatic Arthritis Take a Quiz Project news Handbook Handbook 2 iPROLEPSIS at IEEE EMBC 2026 Read More iPROLEPSIS at SportEx during ECSS 2026 Read More Dynamic Difficulty Adjustment in Psoriatic Arthritis Serious Games Using Learning-Driven Policies Read More DISCOVER MORE Contact us We welcome your comments or questions about iPROLEPSIS project! CONTACT US

iPROLEPSIS project news Aug 26, 2026 Dynamic Difficulty Adjustment in Psoriatic Arthritis Serious Games Using Learning-Driven Policies New iPROLEPSIS publication presents machine learning approach to personalise game difficulty based on patient condition READ MORE Aug 21, 2026 iPROLEPSIS launches IDBV Study Inflammation Digital Biomarkers Validation study begins recruitment on 20 August 2026 READ MORE Jul 21, 2026 iPROLEPSIS Games Presented at Centro Neurológico de Torres Vedras The visit offered an opportunity to present the iPROLEPSIS Games and discuss the project’s work with the centre’s team READ MORE Jun 10, 2026 iPROLEPSIS 8th Plenary Meeting in Athens Partners met to review progress and align on next steps READ MORE Apr 23, 2026 iPROLEPSIS presented at the European OHDSI Symposium 2026 A poster presented in Rotterdam highlighted cross-country harmonization of psoriatic arthritis cohorts into the OMOP Common Data Model READ MORE Mar 16, 2026 iPROLEPSIS at BIOSTEC 2026 Presenting iPROLEPSIS at an international forum on biomedical engineering and health technology READ MORE Feb 5, 2026 Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs New iPROLEPSIS publication presents a smartphone-based approach for remote joint swelling assessment in psoriatic arthritis READ MORE Aug 26, 2026 iPROLEPSIS at IEEE EMBC 2026 Representing iPROLEPSIS at an international biomedical engineering conference READ MORE Aug 18, 2026 iPROLEPSIS at SportEx during ECSS 2026 Connecting iPROLEPSIS with the sport science community READ MORE Jun 26, 2026 iPROLEPSIS presented at DSAI 2026 Digital biomarkers, serious games and AI-supported health monitoring READ MORE May 27, 2026 iPROLEPSIS at the Aristotle Innovation Forum 2026 Showcasing digital health tools for psoriatic arthritis care READ MORE Apr 22, 2026 iPROLEPSIS presented at TeraMed Conference 2026 in Angola The project and the iPROLEPSIS Games were presented, highlighting their relevance for digital health innovation READ MORE Mar 10, 2026 iPROLEPSIS Newsletter No. 11 Latest News from iPROLEPSIS READ MORE Feb 4, 2026 Designing Exergames for Psoriatic Arthritis: The Spy and Zen Forest Paradigms New iPROLEPSIS publication presents the co-design of exergames to support physical activity and rehabilitation in psoriatic arthritis READ MORE Aug 24, 2026 The Spy and Zen Forest Exergames as Sources of Digital Biomarkers for Psoriatic Arthritis: A Co-Design Paradigm New iPROLEPSIS publication presents co-designed exergames to support therapeutic engagement in psoriatic arthritis READ MORE Jul 22, 2026 iPROLEPSIS Newsletter No. 12 Latest news from iPROLEPSIS READ MORE Jun 15, 2026 iPROLEPSIS Research Presented at the 60th ESCI Annual Scientific Meeting From Sensors to Predictive Algorithms: Real-World Digital Biomarkers of Disease Activity in Psoriatic Arthritis READ MORE May 18, 2026 Transforming Psoriatic Disease Care Through Innovation and Real-World Data: GRAPPA 2025 Soapbox Highlights The article highlights how iPROLEPSIS uses digital tools, smartphone-based data and explainable AI to support personalised psoriatic arthritis monitoring READ MORE Apr 1, 2026 iPROLEPSIS at Healthcare & Medical Equipment Korea 2026 Presenting iPROLEPSIS at Korea’s leading medical technology exhibition READ MORE Mar 3, 2026 AI-Driven Early Prediction and Personalised Care | iPROLEPSIS, AI-PROGNOSIS & REBECCA A joint video highlighting how digital biomarkers and real-world data support patient-centred healthcare across three disease areas READ MORE 1 2 3 ... 7 1 ... 1 2 3 4 5 6 7 ... 7

< BACK Dynamic Difficulty Adjustment in Psoriatic Arthritis Serious Games Using Learning-Driven Policies Aug 26, 2026 New iPROLEPSIS publication presents machine learning approach to personalise game difficulty based on patient condition A new iPROLEPSIS publication presents a system that automatically adjusts game difficulty to match each patient's changing condition during therapeutic gameplay. The study proposes a Dynamic Difficulty Adjustment (DDA) system using machine learning – specifically Reinforcement Learning and Multi-Armed Bandits –to personalise how two serious games challenge players: Mr. Blue Sky, targeting wrist mobility, and The Kite, focusing on breathing and relaxation. Data were collected from 32 participants playing these games, tracking gameplay performance, physiological signals (heart rate and stress), and self-reported relaxation levels. Machine learning algorithms learned which difficulty progression works best based on how patient condition changes during play. Results showed that the best-performing strategies began gameplay at medium difficulty, then adjusted downward. In a feasibility pilot with six psoriatic arthritis patients, this automatic adjustment produced coherent therapeutic progressions while accounting for the fluctuating nature of patient symptoms. The system demonstrates how machine learning can support personalised rehabilitation, continuously adapting game challenges to patient needs rather than using fixed difficulty levels. Read the full publication: https://ieeexplore.ieee.org/document/11663158 iPROLEPSIS_Dynamic Difficulty adjustment in PsA publication.png iPROLEPSIS_Dynamic Difficulty adjustment in PsA publication.png 1/1 PREVIOUS NEXT

< BACK Innovative Digital Solutions for Psoriatic Arthritis: A Spotlight on the iPROLEPSIS Project by Prof. Leontios Hadjileontiadis Feb 14, 2024 Empowering Patients, Pioneering Solutions, and Bridging Gaps in Psoriatic Arthritis Knowledge Prof. Leontios Hadjileontiadis, the coordinator of the iPROLEPSIS project, shares how the iPROLEPSIS project addresses psoriatic arthritis research . iPROLEPSIS aims to identify triggers behind the transition from psoriasis to psoriatic arthritis, employing digital models and everyday devices like smartphones and smartwatches to understand disease dynamics. Beyond research, iPROLEPSIS introduces practical solutions such as biAURA for pain relief through sound and serious games targeting exercise, emotion, nutrition, and pain management. Collaborating with 15 partners, including patient advocates, iPROLEPSIS adopts a co-creation approach , bridging technological innovation with real-world healthcare practices. Focusing on predictive and preventive healthcare, iPROLEPSIS strives to fill the knowledge gap surrounding psoriatic arthritis, transforming the research landscape. Watch the full interview: https://www.youtube.com/watch?v=HpiUosn6ETQ leontios_edited.jpg leontios_edited.jpg 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Showcased at MEDICA 2025 Nov 25, 2025 Project presented by PLUX at an international medical technology trade fair MEDICA 2025 was held in Düsseldorf, Germany, from 17–20 November 2025 and is one of the largest international trade fairs for medical technology and healthcare. iPROLEPSIS was showcased by project partner PLUX at MEDICA 2025, within a shared exhibition space alongside other Portuguese entities. The event offered an opportunity to present the project to industry and healthcare stakeholders and to engage with a broad international audience. MEDICA 2025 2.HEIC MEDICA 2025 1.HEIC MEDICA 2025 2.HEIC 1/2 PREVIOUS NEXT

< BACK Developing Sensorimotor Art Games for Psoriatic Arthritis using Agile Storyboarding and Game Co-Design Processes Jul 31, 2024 Innovative Sensorimotor Art Games for Psoriatic Arthritis: Agile Storyboarding and Co-Design Approaches Serious Games (SGs) have the potential to provide clinical care and enhance patients’ quality of life, while incorporating an element of entertainment. As part of the iPROLEPSIS Horizon Europe project, we introduce two Sensorimotor Art games designed as SGs to assist Psoriatic Arthritis (PsA) patients in managing their symptoms. These SGs provide a platform for self-expression and pain relief through engaging in rhythmic puzzle activities. The co-design process for the proposed Sensorimotor Art games followed an agile methodology, involving 14 experts (including clinicians, researchers, and game developers), to gather feedback on game requirements, storyboards, and mechanics. From the thematic analysis of the transcribed discussion, four main themes emerged, namely: Clinical value (Theme 1), Motor skills and adaptation (Theme 2), Creative engagement (Theme 3), and Feedback and future directions (Theme 4). Clinical value underlines the therapeutic benefits of Sensorimotor Art games for pain distraction and emotional well-being. Motor skills and adaptation focus on hand/finger use and adapting games for older patients. Creative engagement emphasizes fostering creativity, a positive environment, and goal achievement. Finally, Feedback and future directions highlight the importance of continuous feedback and occupational therapists’ involvement in coming sessions. The development of Sensorimotor Art games lays the groundwork for digital interventions to alleviate psychological distress and improve fine motor symptoms in PsA patients. At the same time, these SGs can also provide insights to healthcare providers and policymakers for developing future digital solutions tailored to PsA patients. Read the full publication: https://zenodo.org/records/13142606 Ramalho et al_DSAI_2024 .pdf Download PDF • 1.29MB 1/1 PREVIOUS NEXT

iPROLEPSIS project newsletter Jul 21, 2026 Issue No. 12 iPROLEPSIS project newsletter No 12 Welcome! This is the 12th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Mar 10, 2026 Issue No. 11 iPROLEPSIS project newsletter No 11 Welcome! This is the 11th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Nov 6, 2025 Issue No. 10 iPROLEPSIS project newsletter No 10 Welcome! This is the 10th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Jul 1, 2025 Issue No. 9 iPROLEPSIS project newsletter No 9 Welcome! This is the 9th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Apr 28, 2025 Issue No. 8 iPROLEPSIS project newsletter No 8 Welcome! This is the 8th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Jan 28, 2025 Issue No. 7 iPROLEPSIS project newsletter No 7 Welcome! This is the 7th edition of the Newsletter series of the iPROLEPSIS project. In this issue, we highlight the insights on the future of digital biomarkers in rheumatology care, offer key information about PsA and practical advice to improve daily life, update about past events. READ THE NEWSLETTER Oct 9, 2024 Issue No. 6 iPROLEPSIS project newsletter No 6 Welcome! This is the 6th edition of the Newsletter series of the iPROLEPSIS project. In this issue, we highlight the release of the miPROLEPSIS and miPROLEPSIS Joint Landmarker apps, recent publications, reflections on Psoriatic Arthritis Awareness Day and Psoriasis Awareness Month, and key takeaways from recent events. READ THE NEWSLETTER Jul 9, 2024 Issue No. 5 iPROLEPSIS project newsletter No 5 Welcome! This is the 5th edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the updates and progress of the project activities, synergies and events. READ THE NEWSLETTER Mar 7, 2024 Issue No. 4 iPROLEPSIS project newsletter No 4 Welcome! This is the 4th edition of the Newsletter series of the iPROLEPSIS project. Let's explore the latest developments and advancements in our project activities, collaborations, and upcoming events. READ THE NEWSLETTER Nov 30, 2023 Issue No. 3 iPROLEPSIS project newsletter No 3 Welcome! This is the 3rd edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the updates and progress of the project activities, synergies and events. READ THE NEWSLETTER Sep 5, 2023 Issue No. 2 iPROLEPSIS project newsletter No 2 Welcome! This is the 2nd edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the transformative power of user research and co-creation in the healthcare innovation research process. READ THE NEWSLETTER Jul 4, 2023 Issue No. 1 iPROLEPSIS project newsletter No 1 Welcome! This is the 1st edition of the newsletter series of the iPROLEPSIS project! The 1st newsletter informs you about the iPROLEPSIS project, its vision, pillars and objectives, and the partners involved. READ THE NEWSLETTER

Download needed promo materials for iProlepsis project for psoriatic arthritis, such as posters, flyers, logos, and color palete. Promo materials to download 01 iPROLEPSIS Poster (A0) 02 iPROLEPSIS Flyer (A5) 03 iPROLEPSIS Roll-Up Poster Logo and color palette to download PNG, transparent background SVG, transparent background SVG, transparent background #212178 #B380FF #FFAACC #37C8AB #DEEBF7 PNG, white background WEBP, transparent background

We welcome your comments or questions about iPROLEPSIS project!​ Feel free to contact us by filling in the form to submit your comments or questions.​ Project coordinator Prof. Leontios Hadjileontiadis Project Coordinator Aristotle University of Thessaloniki Contact us We welcome your comments or questions about iPROLEPSIS! Please contact us by filling in the form below to submit your comments or questions. Ask your question or write a comment First name Last name Email Write a message I have read and agree to the Privacy policy SUBMIT Thanks for submitting! Please note that we will not give you medical advice. To discuss symptoms or conditions, please contact your physician or other health care provider.

< BACK Khalifa University Features iPROLEPSIS in Research News Jun 2, 2025 AI, Apps and Arthritis: A Digital Leap in Psoriatic Care Khalifa University Research News has featured iPROLEPSIS in a new article showcasing our mission to transform psoriatic arthritis care through digital innovation. Led by Prof. Leontios Hadjileontiadis, iPROLEPSIS is a Horizon Europe-funded initiative using artificial intelligence, wearable technology, and mobile health apps to shift care from reactive treatment to proactive prevention . By combining explainable AI with real-world patient data, we aim to support earlier diagnosis , personalized treatment , and patient-centered digital tools that empower both clinicians and individuals living with psoriatic arthritis. Read the full article on Khalifa University website: https://www.ku.ac.ae/ai-apps-and-arthritis-a-digital-leap-in-psoriatic-care Hero section.png Hero section.png 1/1 PREVIOUS NEXT