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iPROLEPSIS project news Mar 10, 2026 iPROLEPSIS Newsletter No. 11 Latest News from iPROLEPSIS READ MORE Feb 4, 2026 Designing Exergames for Psoriatic Arthritis: The Spy and Zen Forest Paradigms New iPROLEPSIS publication presents the co-design of exergames to support physical activity and rehabilitation in psoriatic arthritis READ MORE Dec 12, 2025 iPROLEPSIS 7th Plenary Meeting in Lisbon Partners met to review progress and next steps READ MORE Nov 24, 2025 iPROLEPSIS Games Showcased at Lisboa Games Week 2025 The FMH/IST-ULisboa team presented the iPROLEPSIS Games, connecting with the gaming community and industry stakeholders READ MORE Nov 3, 2025 iPROLEPSIS at IEEE HealthCom 2025: AI-Enabled Digital Health for Psoriatic Arthritis Project researchers presented new studies, co-chaired a workshop, and joined a panel on digital innovation in healthcare in Abu Dhabi READ MORE Oct 14, 2025 The iPROLEPSIS Learning Hub Has Been Renewed A refreshed space to learn more about psoriatic arthritis READ MORE Sep 11, 2025 Digital Innovation for Psoriatic Arthritis Prevention An interview with iPROLEPSIS coordinators in Thessalonikeon Polis on how digital tools, wearables, and AI can help prevent psoriatic arthritis READ MORE Mar 3, 2026 AI-Driven Early Prediction and Personalised Care | iPROLEPSIS, AI-PROGNOSIS & REBECCA A joint video highlighting how digital biomarkers and real-world data support patient-centred healthcare across three disease areas READ MORE Feb 3, 2026 Co-Designing Mobile Serious Games to Support Patients With Psoriatic Arthritis and Chronic Pain: Mixed Methods Study New peer-reviewed publication from iPROLEPSIS READ MORE Dec 4, 2025 iPROLEPSIS at Faculdade de Motricidade Humana PhD Seminar Lecture on recent findings shared with PhD students READ MORE Nov 6, 2025 iPROLEPSIS at IEEE-EMBS BSN 2025 Showcasing iPROLEPSIS at a leading international conference on body sensor research READ MORE Oct 29, 2025 World Psoriasis Day: iPROLEPSIS featured by HaDEA On World Psoriasis Day, the European Health and Digital Executive Agency (HaDEA) highlights how the iPROLEPSIS project is advancing early detection and personalised care for psoriatic arthritis READ MORE Oct 8, 2025 iPROLEPSIS presented at the MULTIPULM project kick-off meeting iPROLEPSIS tools to be adapted for clinical studies in Brazil, Serbia, and Türkiye READ MORE Jul 24, 2025 iPROLEPSIS Games Pitch video from HiTech 2025 iPROLEPSIS Games presented during the HiSeedTech programme READ MORE Feb 5, 2026 Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs New iPROLEPSIS publication presents a smartphone-based approach for remote joint swelling assessment in psoriatic arthritis READ MORE Dec 23, 2025 Seasons Greetings from iPROLEPSIS Happy holidays and best wishes for the year ahead! READ MORE Nov 25, 2025 iPROLEPSIS Showcased at MEDICA 2025 Project presented by PLUX at an international medical technology trade fair READ MORE Nov 6, 2025 iPROLEPSIS Newsletter No. 10 Latest News from iPROLEPSIS READ MORE Oct 29, 2025 World Psoriasis Day 2025: Advancing Prevention and Care On World Psoriasis Day, iPROLEPSIS highlights ongoing efforts to improve early detection, prevention, and digital support for people living with psoriasis and psoriatic arthritis READ MORE Oct 2, 2025 iPROLEPSIS at the European Researchers’ Night 2025 Presentation of the iPROLEPSIS Games in Oeiras, Portugal by FMH/IST-ULisboa researchers READ MORE 1 2 3 ... 6 1 ... 1 2 3 4 5 6 ... 6

< BACK iPROLEPSIS Newsletter No. 11 Mar 10, 2026 Latest News from iPROLEPSIS Welcome to the eleventh edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter Issue No. 11_March 2026 .pdf Download PDF • 3.99MB iPROLEPSIS_Newsletter 11.png iPROLEPSIS_Newsletter 11.png 1/1 PREVIOUS NEXT

The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalized digital care ecosystem. iPROLEPSIS is a s olution for psoriatic arthritis The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalised digital care ecosystem. ABOUT CONSORTIUM CONTACT US March 2026 TODAY Mon Tue Wed Thu Fri Sat Sun 23 24 25 26 27 28 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 1 2 3 4 5 Upcoming events Psoriatic Arthritis (PsA) is a chronic progressive inflammatory disease affecting 1-2% of the general population, while manifesting in up to 30% of people with psoriasis (PsO). Project vision and impact iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with PsA. The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real World Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. DISCOVER MORE Project objectives and work packages iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA) and has 6 Work Packages of the project that will bring together various and complementary expertise from consortium partners. DISCOVER MORE About project 15 Partners 9 Countries 48 m Project duration € 6,4M Total budget The core activity domains Establishment • The foundation for the project’s research activities is laid by means of an extensive exploration of the available literature and data and the design of the clinical data collection and validation studies; • Participatory design supporting the development of a user-oriented ecosystem of solutions will be employed to establish a framework for trustworthy AI-based R&D. Validation • The design and implementation of the clinical studies that will collect research data, validate the inflammatory symptoms digital biomarkers in individuals at risk of PsA and PSO patients, and evaluate the efficacy of the digital care tools with respect to prevention of inflammation exacerbation. Research and development • Research on multimodal data to reveal key PsA inflammation drivers, provide digital biomarkers of PsA inflammatory symptoms, and explore the effect of PsA on the joints and skin microvasculature, as well as the role of mast cells in PsA transition; • Synthesise the outcomes into a multiscale/multifactorial model of the health-to-PsA transition; • Deliver the integrated iPROLEPSIS digital health ecosystem comprising tools for personalised preventive PsA care, to empower patients and HCPs. Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Handbook Handbook 2 Psoriatic Arthritis Key Facts Key Facts Psoriatic Arthritis Handbook Handbook Quizzes about Psoriatic Arthritis Take a Quiz Project news Handbook Handbook 2 iPROLEPSIS Newsletter No. 11 Read More AI-Driven Early Prediction and Personalised Care | iPROLEPSIS, AI-PROGNOSIS & REBECCA Read More Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs Read More DISCOVER MORE Contact us We welcome your comments or questions about iPROLEPSIS project! CONTACT US

iPROLEPSIS project newsletter Mar 10, 2026 Issue No. 11 iPROLEPSIS project newsletter No 11 Welcome! This is the 11th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Nov 6, 2025 Issue No. 10 iPROLEPSIS project newsletter No 10 Welcome! This is the 10th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Jul 1, 2025 Issue No. 9 iPROLEPSIS project newsletter No 9 Welcome! This is the 9th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Apr 28, 2025 Issue No. 8 iPROLEPSIS project newsletter No 8 Welcome! This is the 8th edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. READ THE NEWSLETTER Jan 28, 2025 Issue No. 7 iPROLEPSIS project newsletter No 7 Welcome! This is the 7th edition of the Newsletter series of the iPROLEPSIS project. In this issue, we highlight the insights on the future of digital biomarkers in rheumatology care, offer key information about PsA and practical advice to improve daily life, update about past events. READ THE NEWSLETTER Oct 9, 2024 Issue No. 6 iPROLEPSIS project newsletter No 6 Welcome! This is the 6th edition of the Newsletter series of the iPROLEPSIS project. In this issue, we highlight the release of the miPROLEPSIS and miPROLEPSIS Joint Landmarker apps, recent publications, reflections on Psoriatic Arthritis Awareness Day and Psoriasis Awareness Month, and key takeaways from recent events. READ THE NEWSLETTER Jul 9, 2024 Issue No. 5 iPROLEPSIS project newsletter No 5 Welcome! This is the 5th edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the updates and progress of the project activities, synergies and events. READ THE NEWSLETTER Mar 7, 2024 Issue No. 4 iPROLEPSIS project newsletter No 4 Welcome! This is the 4th edition of the Newsletter series of the iPROLEPSIS project. Let's explore the latest developments and advancements in our project activities, collaborations, and upcoming events. READ THE NEWSLETTER Nov 30, 2023 Issue No. 3 iPROLEPSIS project newsletter No 3 Welcome! This is the 3rd edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the updates and progress of the project activities, synergies and events. READ THE NEWSLETTER Sep 5, 2023 Issue No. 2 iPROLEPSIS project newsletter No 2 Welcome! This is the 2nd edition of the Newsletter series of the iPROLEPSIS project. In this newsletter issue, we delve into the transformative power of user research and co-creation in the healthcare innovation research process. READ THE NEWSLETTER Jul 3, 2023 Issue No. 1 iPROLEPSIS project newsletter No 1 Welcome! This is the 1st edition of the newsletter series of the iPROLEPSIS project! The 1st newsletter informs you about the iPROLEPSIS project, its vision, pillars and objectives, and the partners involved. READ THE NEWSLETTER

< BACK AI-Driven Early Prediction and Personalised Care | iPROLEPSIS, AI-PROGNOSIS & REBECCA Mar 3, 2026 A joint video highlighting how digital biomarkers and real-world data support patient-centred healthcare across three disease areas What happens when a disease enters someone’s life and changes everything? Millions of people live with chronic conditions that shape their daily routines – often in ways that are invisible to others. Early diagnosis, timely intervention and more effective care can make a profound difference. In a new joint video developed with support from the European Commission’s Booster initiative, the EU-funded projects iPROLEPSIS , AI-PROGNOSIS and REBECCA present a shared vision for patient-centred artificial intelligence in healthcare. The video highlights how AI and digital biomarkers can enable earlier prediction, continuous monitoring and more personalised care across three disease areas: Psoriatic arthritis (iPROLEPSIS) Parkinson’s disease (AI-PROGNOSIS) Breast cancer survivorship (REBECCA) By integrating real-world behavioural data, wearable sensor signals and patient-reported information, the projects demonstrate how complex health data can be transformed into actionable clinical insights. These AI-driven approaches aim to strengthen clinical decision-making while keeping patients at the centre of care. The video reflects the projects’ commitment to developing trustworthy, responsible and co-designed AI solutions that respond to real clinical and patient needs. Watch the video here: To learn more, visit: iPROLEPSIS – https://www.iprolepsis.eu AI-PROGNOSIS – https://www.ai-prognosis.eu REBECCA – https://www.rebeccaproject.eu Screenshot 2026-03-02 115452.png Screenshot 2026-03-02 115452.png 1/1 PREVIOUS NEXT

Read publications about iProlepsis project for psoriatic arthritis. Discover insights and project progress. iPROLEPSIS project publications Modeling Interphalangeal Joints for Swelling Assessment in Psoriatic Arthritis via Smartphone Photographs February 4, 2026 Digital assessment of swollen joints from smartphone photographs can support remote monitoring of patients with inflammatory arthritis, enabling more efficient care delivery. In this study, we propose a method to classify each interphalangeal joint in hand photographs as swollen or not. Read More European advances in digital rheumatology: explainable insights and personalized digital health tools for psoriatic arthritis May 19, 2025 The shift from traditional to technology-based diagnosis and management of psoriatic arthritis (PsA) represents a significant evolution in patient care. Traditionally, PsA was diagnosed and managed through clinical evaluations, physical examinations, and basic imaging techniques. With the evolution of digital technologies, the PsA care is transforming, giving rise to the field of digital rheumatology. In this vein, Europe has invested in research initiatives, like iPROLEPSIS, that could accelerate this transformation and redefine PsA care within a digital world. In this Viewpoint we present the current clinical PsA landscape, highlight the PsA patients' interaction with the digital world, and showcase the novel iPROLEPSIS digital offerings. The latter scaffold digital rheumatology by identifying PsA key drivers. Moreover, they support personalized PsA risk prediction and improve early PsA detection. Furthermore, they enable precise PsA treatment strategies and digital therapeutics within a novel digital health ecosystem. Read More Developing Sensorimotor Art Games for Psoriatic Arthritis using Agile Storyboarding and Game Co-Design Processes June 28, 2024 Serious Games (SGs) have the potential to provide clinical care and enhance patients’ quality of life, while incorporating an element of entertainment. As part of the iPROLEPSIS Horizon Europe project, we introduce two Sensorimotor Art games designed as SGs to assist Psoriatic Arthritis (PsA) patients in managing their symptoms. Read More Can ChatGPT provide appropriate meal plans for NCD patients? May 30, 2024 Dietary habits significantly affect health conditions and are closely related to the onset and progression of non-communicable diseases (NCDs). Consequently, a well-balanced diet plays an important role in lessening the effects of various disorders, including NCDs. Read More Designing Exergames for Psoriatic Arthritis: The Spy and Zen Forest Paradigms February 4, 2026 In addition to biological interventions, traditional treatments often include physiotherapy and exercise to improve range of motion and physical function. However, a prevalence of low consistency, high costs, and lack of engagement leads to high drop-out rates, making these interventions ineffective. Exergames, short for exercise games, provide an accessible alternative to complement traditional interventions, which embed therapeutic movements into game mechanics, motivating patients to remain active and consistent in their rehabilitation routines. Here we present the design of two exergames for PsA, namely The Spy and Zen Forest. Read More Hot topic debate: preventing psoriatic arthritis in patients with psoriasis November 11, 2024 Can effective treatment of psoriasis (PsO) prevent the development of psoriatic arthritis (PsA)? In a Hot Topic Debate at the 7th World Psoriasis & Psoriatic Arthritis Conference, Dr. Soriano and Dr. Ogdie, both experts in the field, presented contrasting views based on existing research and clinical studies.1 Dr. Soriano argued that biologic treatments for PsO may reduce PsA risk, citing several retrospective studies. On the other hand, Dr. Ogdie argued that current observational data are plagued by biases, making it difficult to conclude whether biologics play a protective role. The session outlined the complexity of this issue, with both speakers agreeing on the need for prospective randomised controlled trials, such as the ongoing PAMPA study, to provide definitive answers. Prof. Laura Coates added that identifying at-risk patients and intervening early to potentially prevent PsA may point to a strategic research approach to address these unanswered questions. Read More “The Kite” Breathing Serious Game: Agile Co-Design for Psoriatic Arthritis June 27, 2024 Serious Games (SGs) have been explored in healthcare for their potential as gamified means for disease assessment and/or intervention. Designing effective SGs requires attention to user requirements and iterative development. We introduce a SG design process for Psoriatic Arthritis (PsA) patients, aiming to enhance their quality of life. Read More AI nutrition recommendation using a deep generative model and ChatGPT May 31, 2024 In recent years, major advances in artificial intelligence (AI) have led to the development of powerful AI systems for use in the field of nutrition in order to enhance personalized dietary recommendations and improve overall health and well-being. Read More Co-Designing Mobile Serious Games to Support Patients With Psoriatic Arthritis and Chronic Pain: Mixed Methods Study February 3, 2026 This study aimed to co-design mobile serious games—NoPain Games—to support patients with PsA in managing chronic pain. Conducted within the iPROLEPSIS Horizon Europe project, the study involved a multidisciplinary cocreation session with rheumatologists, researchers, and technical experts, followed by a usability feedback session with patients with PsA. The goal was to identify therapeutic priorities, refine game mechanics, and assess usability to inform the development of personalized, accessible digital interventions. Read More Digital biomarkers for psoriatic arthritis: a qualitative focus group study on patient-perceived opportunities and barriers October 30, 2024 The widespread adoption of wearables, for example, smartphones and smartwatches in the daily lives of the general population, allows passive monitoring of physiological and behavioural data in the real world. This qualitative study explores the perspective of psoriatic arthritis (PsA) patients towards these so-called digital biomarkers (dBMs). Read More ChatGPT in Nutrition: Trends Challenges and Future Directions June 26, 2024 A healthy and balanced diet is of paramount importance to the physical and psychological well-being of an individual, since unhealthy dietary choices have been linked with the occurrence of non-communicable diseases. Read More Developing Exergames for Psoriatic Arthritis using Agile Storyboarding and Game Design Processes June 26, 2024 Serious Games (SGs) offer significant potential in healthcare for disease assessment and intervention, enhancing patients’ quality of life. Exercise SGs, or Exergames, promote physical activity and mobility in a gamified environment, encouraging tailored exercises based on individual abilities and needs. Read More

< BACK iPROLEPSIS presented at the MULTIPULM project kick-off meeting Oct 8, 2025 iPROLEPSIS tools to be adapted for clinical studies in Brazil, Serbia, and Türkiye The iPROLEPSIS project was presented during the kick-off meeting of the MULTIPULM project, held on 29–30 September in Athens. iPROLEPSIS partners Aristotle University of Thessaloniki (AUTH) , Faculdade de Motricidade Humana (FMH) , and Wellics participated in the meeting, which brought together researchers, clinicians, user research experts, and technology providers. Several tools developed within iPROLEPSIS – including the breathing games created by FMH and the biAURA app developed by AUTH – will be further used in MULTIPULM. These tools will be adapted to the local needs of the project’s pilot sites in Brazil, Serbia, and Türkiye, and evaluated in relevant clinical studies. This collaboration demonstrates the adaptability and broader potential of iPROLEPSIS digital tools beyond psoriatic arthritis, supporting research in other chronic conditions. SPBTU_KoM_MULTIPULM_Athens.jpg ae74e3_e25adf83abf6411cace29ed99801554f~mv2.jpg SPBTU_KoM_MULTIPULM_Athens.jpg 1/2 PREVIOUS NEXT

< BACK Ongoing preparation for the iPROLEPSIS-PDPID study Mar 4, 2024 iPROLEPSIS-PDPID Study: Advancing Psoriatic Arthritis through Innovative Digital Biomarkers Patients with Psoriatic arthritis (PsA) experience difficulties in dealing with unpredictable disease activity, which can affect their quality of life. Developing a digital biomarker using a smartphone and smartwatch would allow for unobtrusive monitoring of the disease activity in these patients. Besides, understanding what factors trigger flare would allow for better disease control. The iPROLEPSIS-PDPID study is a multicentre observational cohort study that aims to develop an unobtrusive and affordable digital biomarker capable of detecting changes in disease activity, including flare, and to identify triggers of flare in patients with PsA. The study will be conducted in four countries: the Netherlands, the UK, Portugal and Greece. Ethical approval for initiating the iPROLEPSIS-PDPID study in the Netherlands and the UK has been granted. The OpenClinica platform will be used in the collection and storage of data for the iPROLEPSIS-PDPID study. Future steps include obtaining ethical approvals for Portugal and Greece as well as local approvals from centres participating in each country, and inclusion of patients from each participating country. The miPROLEPSIS phone app , currently under development, will be used in this study. The app will be installed on the patient smartphone and utilised as a data collector, which will be then used for algorithms development and training. The app will measure physical activity, the length of sleep, self-registered flare, and register daily pain, fatigue, sleep and morning stiffness. The Garmin smartwatch Vivoactive 5 device will be used to collect data on physical activity, heart rate, heart rate variability and sleep quality. The collected data from Garmin will be downloaded from the miPROLEPSIS app by Wellics software (developer in the project), which allows extracting, visualising and exporting collected both company-processed data, as well as raw data. 10.png 13.png 14.png 10.png 1/5 PREVIOUS NEXT

Data science team Konstantinidis Dimitrios CERTH Position Postdoctoral researcher What is your role in iPROLEPSIS? Researcher and technical developer What are your main activities in the project? I am mainly involved in the research activities of CERTH, concerning psoriatic nail detection and classification, range-of-motion assessment through the execution of active video tests and nutrition and physical activity recommendations. What is your motivation? I am deeply passionate about artificial intelligence and deep learning, with a strong interest in uncovering hidden patterns within data that can lead to highly accurate and reliable predictions. I find great satisfaction in developing advanced machine learning techniques to transform data into innovative solutions that contribute to real-world progress. Nikos Melanitis Ainigma Position Data Scientist What is your role in iPROLEPSIS? Data Scientist, Digital health and predictive modelling What are your main activities in the project? To design and implement novel approaches for improved management of PsA, through personalized models that warn patients for high risk of PsA exacerbation (flare). What is your motivation? To be part of the digital innovation in Health, enabling better disease management and personalised, precision medicine. Kosmas Dimitropoulos CERTH Position Principal Researcher (Researcher of Grade B’) What is your role in iPROLEPSIS? Principal Investigator for CERTH What are your main activities in the project? I am mainly involved in the research activities of CERTH, concerning psoriatic nail detection and classification, range-of-motion assessment through the execution of active video tests and nutrition and physical activity recommendations. What is your motivation? I am deeply motivated by the intersection of Artificial Intelligence and healthcare. I aspire to contribute to research that applies deep learning techniques to personalized medicine, enabling more accurate, data-driven, and patient-specific approaches to diagnosis and treatment. Eleni Vasileiou Signal Processing & Biomedical Technology Unit (SPBTU) – Aristotle University of Thessaloniki (AUTH) Position Research assistant working on digital health technologies and AI-enabled healthcare tools What is your role in iPROLEPSIS? AI Researcher & Data Scientist | Digital health and predictive modelling What are your main activities in the project? My main activities focus on developing digital, passively captured indicators that support risk prediction and monitoring models for psoriatic arthritis. I work on digital phenotyping of inflammatory symptoms with an emphasis on tracking motor manifestations using smart devices and wearables. This involves designing methods to analyze data from daily living activities – such as sleep, walking, and hand movements – to capture subtle physiological and behavioral changes associated with disease onset and progression. These efforts aim to identify key drivers of psoriatic arthritis and support personalized models for disease risk, progression prediction, and inflammation monitoring. What is your motivation? I am deeply motivated by the potential of digital health technologies to bring a more human and data-informed approach to healthcare. By combining AI with continuous, real-world data, we can reveal patterns often hidden in traditional clinical assessments. What drives me is the belief that these insights can empower both patients and clinicians to make earlier and more informed decisions, ultimately improving health outcomes and quality of life. My goal is to contribute to a future where technology enhances understanding, prevention, and personalized care for chronic conditions. Coordination Clinical Experts Data Science Software Development Ethics, Legal and Exploitation Dissemination and Communication

iProlepsis project for psoriatic arthritis uses multi-source data analysis for guiding to a novel personalised digital care ecosystem and maximizes the impact. iPROLEPSIS project vision and impact maximisation Health-to-PsA transition through multi-source data analysis guiding to a novel personalised digital care ecosystem and impact maximisation through openness, visibility, networking and reuse of outcomes. Project vision Data analysis, iPROLEPSIS project goals, IoT technologies and mobile application. About Psoriatic Arthritis Psoriatic Arthritis (PsA) is a chronic, inflammatory disease, affecting the peripheral and axial skeleton, with a severe impact on patients’ quality-of-life. It is estimated that 1-2% of the general population has PsA, i.e., 5 to 10 million people in EU are affected . PsA is associated with psoriasis (PsO) and up to 30% of people living with PsO, i.e., at least 100 million people worldwide (WHO), are expected to develop PsA. The goal The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real Worl Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. Technologies IoT sensing technologies and a mobile application will be at the heart of the RWD collection procedure, while retrospective and prospective multi-source data will be collected from the clinical partners’ databases, combined with open access ones. Through the analysis and visualisation of these data using AI predictive models and an intuitive visual analytics tool, respectively, the iPROLEPSIS will be able to propose personalized treatments (i.e., diet, physical activity, stress/fatigue/pain management), assisting doctors, caregivers, and hospitals towards the optimal management of PsA. Finally, through xAI techniques, iPROLEPSIS aims to facilitate hospitals and policy makers in gaining new insights towards better clinical practices, thus shaping future PsA treatment policies. Impact maximisation To ensure the successful implementation of the pathways towards impact in long-term, the project consortium aims at making iPROLEPSIS a reference for the fight against PsA by: 01 Creating an active iPROLEPSIS community of stakeholders. 02 Informing key stakeholders about results and their clinical innovation potential. 03 Making the outputs widely available for research and business purposes in the long term. 04 Increasing people with/at risk of PsA engagement for addressing their issues and concerns in order to increase their awareness and to build trust into new technology. 05 Reaching similar/relevant R&I projects for promoting networking and joint activities. 06 Establishing a forum/community for HCPs and authorities to develop new guidelines and standards. 07 Identifying exploitation mechanisms and activities, assessing the commercialization and applicability of the concepts and ideas. PROJECT OBJECTIVES

iProlepsis psoriatic arthritis project is a comprehensive multiscale model employing novel trustworthy AI-based analysis of multisource and heterogenous data. iPROLEPSIS project objectives and work packages Project aspires to shed light upon the health-to-PsA transition with a comprehensive multiscale / multifactorial PsA model employing novel trustworthy AI-based analysis of multisource and heterogenous (i.a., in-depth health, environmental, genetic, behavioral) data. Project objectives iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA). PsA inflamation drivers Discover PsA inflammation drivers through AI-driven health, environmental and omics data mining. Role of mast cells Investigate the role of mast cells and features from non-invasive skin microvascular/joint imaging in inflammatory symptoms tracking. Personalised interventions Develop ICT-based personalised interventions to sustain or even improve quality-of-life. Co-creative ecosystem Co-create the iPROLEPSIS ecosystem with key stakeholders, following ethical, inclusive and trustworthy AI principles. Digital biomarkers Develop and validate objective digital biomarkers for tracking inflammatory symptoms and disease activity. Trustwothy AI models Build trustworthy AI models for personalised PsA risk prediction, early diagnosis and high disease activity prognosis. Digital health ecosystem Develop and clinically validate the iPROLEPSIS digital health ecosystem to empower persons with/at risk of PsA and healthcare professionals. Work packages The 6 Work Packages of the project will bring together various and complementary expertise from consortium partners. WP1 WP2 WP3 WP4 WP5 WP6 Work Package 1: Management and coordination WP1 is dedicated to project management and coordination aiming to enable a smooth project workflow; Ensure optimal contractual, administrative, financial, scientific, technical, IP and innovation management; Assure project quality and safeguard ethics, regulatory compliance and proper data management. Work Package 2: Knowledge mining, foundation and participatory design WP2 aims to create a foundational body of knowledge concerning PsA, associated conditions and inflammation; Identify, retrieve and curate datasets relevant to R&D activities of the project; Identify user needs and effectively engage with key stakeholders for steering research questions and co-creating the iPROLEPSIS digital care tools; Establish and monitor practices for ensuring adherence of iPROLEPSIS AI-driven components to trustworthy AI principles. Work Package 3: Research on PsA inflammation drivers and monitoring WP3 is dedicated to identify drivers related to PsA and associated inflammation leveraging new and existing multi-source health relevant data; Develop smartphone/wearable-based digital biomarkers (dBMs) for assessing PsA inflammatory symptoms; Shed light on changes in the joints and skin microvasculature related to PsA and the role of mast cells in associated inflammation; Through data fusion, develop a multiscale/multifactorial PsA model, emphasising on the prediction of the transition of high-risk individuals and PsO patients to PsA and of PsA patients to advanced inflammatory state. Work Package 4: Development of the iPROLEPSIS digital health ecosystem for personalised preventive care WP4 will technically specify the iPROLEPSIS ecosystem and set up a robust data management infrastructure and DevOps/MLOps platforms; Through an agile approach, develop the iPROLEPSIS minimum viable products (MVPs) for personalised PsA care including: 1) the patient app incorporating (dBM-based)PsA monitoring, knowledge, targeted interventions and tailored AI-driven lifestyle recommendations, 2) the serious gaming suite for health and wellness, 3) the app for HCPs allowing them to remotely monitor patients and view predictions on their course. Work Package 5: Clinical studies WP5 will develop the study protocols and carry out the process for their timely approval by concerned bodies; Set up a system for coordinating recruitment and efficiently managing clinical data and reporting; Organise and conduct four clinical studies: two multicentre prospective cohort studies for discovery and validation of PsA inflammation drivers and digital biomarkers, one observational study on PsA and changes in the joints and skin microvasculature, and one multicentre proof-of-concept randomised controlled trial (RCT) evaluating the effectiveness of the iPROLEPSIS digital care tools. Work Package 6: Dissemination, communication and exploitation WP6 will maximise visibility of the project and its outcomes and facilitate knowledge exchange while engaging a wide network of stakeholders; Develop PsA-related educational content; Set out a roadmap for regulatory approval of the iPROLEPSIS digital tools; Perform a thorough socio-economic/market analysis and develop concrete joint/individual exploitation plans. PROJECT VISION

We welcome your comments or questions about iPROLEPSIS project!​ Feel free to contact us by filling in the form to submit your comments or questions.​ Project coordinator Prof. Leontios Hadjileontiadis Project Coordinator Aristotle University of Thessaloniki Contact us We welcome your comments or questions about iPROLEPSIS! Please contact us by filling in the form below to submit your comments or questions. Ask your question or write a comment First name Last name Email Write a message I have read and agree to the Privacy policy SUBMIT Thanks for submitting! Please note that we will not give you medical advice. To discuss symptoms or conditions, please contact your physician or other health care provider.