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Data science team Konstantinidis Dimitrios CERTH Position Postdoctoral researcher What is your role in iPROLEPSIS? Researcher and technical developer What are your main activities in the project? I am mainly involved in the research activities of CERTH, concerning psoriatic nail detection and classification, range-of-motion assessment through the execution of active video tests and nutrition and physical activity recommendations. What is your motivation? I am deeply passionate about artificial intelligence and deep learning, with a strong interest in uncovering hidden patterns within data that can lead to highly accurate and reliable predictions. I find great satisfaction in developing advanced machine learning techniques to transform data into innovative solutions that contribute to real-world progress. Nikos Melanitis Ainigma Position Data Scientist What is your role in iPROLEPSIS? Data Scientist, Digital health and predictive modelling What are your main activities in the project? To design and implement novel approaches for improved management of PsA, through personalized models that warn patients for high risk of PsA exacerbation (flare). What is your motivation? To be part of the digital innovation in Health, enabling better disease management and personalised, precision medicine. Kosmas Dimitropoulos CERTH Position Principal Researcher (Researcher of Grade B’) What is your role in iPROLEPSIS? Principal Investigator for CERTH What are your main activities in the project? I am mainly involved in the research activities of CERTH, concerning psoriatic nail detection and classification, range-of-motion assessment through the execution of active video tests and nutrition and physical activity recommendations. What is your motivation? I am deeply motivated by the intersection of Artificial Intelligence and healthcare. I aspire to contribute to research that applies deep learning techniques to personalized medicine, enabling more accurate, data-driven, and patient-specific approaches to diagnosis and treatment. Eleni Vasileiou Signal Processing & Biomedical Technology Unit (SPBTU) – Aristotle University of Thessaloniki (AUTH) Position Research assistant working on digital health technologies and AI-enabled healthcare tools What is your role in iPROLEPSIS? AI Researcher & Data Scientist | Digital health and predictive modelling What are your main activities in the project? My main activities focus on developing digital, passively captured indicators that support risk prediction and monitoring models for psoriatic arthritis. I work on digital phenotyping of inflammatory symptoms with an emphasis on tracking motor manifestations using smart devices and wearables. This involves designing methods to analyze data from daily living activities – such as sleep, walking, and hand movements – to capture subtle physiological and behavioral changes associated with disease onset and progression. These efforts aim to identify key drivers of psoriatic arthritis and support personalized models for disease risk, progression prediction, and inflammation monitoring. What is your motivation? I am deeply motivated by the potential of digital health technologies to bring a more human and data-informed approach to healthcare. By combining AI with continuous, real-world data, we can reveal patterns often hidden in traditional clinical assessments. What drives me is the belief that these insights can empower both patients and clinicians to make earlier and more informed decisions, ultimately improving health outcomes and quality of life. My goal is to contribute to a future where technology enhances understanding, prevention, and personalized care for chronic conditions. Coordination Clinical Experts Data Science Software Development Ethics, Legal and Exploitation Dissemination and Communication

iProlepsis project for psoriatic arthritis uses multi-source data analysis for guiding to a novel personalised digital care ecosystem and maximizes the impact. iPROLEPSIS project vision and impact maximisation Health-to-PsA transition through multi-source data analysis guiding to a novel personalised digital care ecosystem and impact maximisation through openness, visibility, networking and reuse of outcomes. Project vision Data analysis, iPROLEPSIS project goals, IoT technologies and mobile application. About Psoriatic Arthritis Psoriatic Arthritis (PsA) is a chronic, inflammatory disease, affecting the peripheral and axial skeleton, with a severe impact on patients’ quality-of-life. It is estimated that 1-2% of the general population has PsA, i.e., 5 to 10 million people in EU are affected . PsA is associated with psoriasis (PsO) and up to 30% of people living with PsO, i.e., at least 100 million people worldwide (WHO), are expected to develop PsA. The goal The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real Worl Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. Technologies IoT sensing technologies and a mobile application will be at the heart of the RWD collection procedure, while retrospective and prospective multi-source data will be collected from the clinical partners’ databases, combined with open access ones. Through the analysis and visualisation of these data using AI predictive models and an intuitive visual analytics tool, respectively, the iPROLEPSIS will be able to propose personalized treatments (i.e., diet, physical activity, stress/fatigue/pain management), assisting doctors, caregivers, and hospitals towards the optimal management of PsA. Finally, through xAI techniques, iPROLEPSIS aims to facilitate hospitals and policy makers in gaining new insights towards better clinical practices, thus shaping future PsA treatment policies. Impact maximisation To ensure the successful implementation of the pathways towards impact in long-term, the project consortium aims at making iPROLEPSIS a reference for the fight against PsA by: 01 Creating an active iPROLEPSIS community of stakeholders. 02 Informing key stakeholders about results and their clinical innovation potential. 03 Making the outputs widely available for research and business purposes in the long term. 04 Increasing people with/at risk of PsA engagement for addressing their issues and concerns in order to increase their awareness and to build trust into new technology. 05 Reaching similar/relevant R&I projects for promoting networking and joint activities. 06 Establishing a forum/community for HCPs and authorities to develop new guidelines and standards. 07 Identifying exploitation mechanisms and activities, assessing the commercialization and applicability of the concepts and ideas. PROJECT OBJECTIVES

iProlepsis psoriatic arthritis project is a comprehensive multiscale model employing novel trustworthy AI-based analysis of multisource and heterogenous data. iPROLEPSIS project objectives and work packages Project aspires to shed light upon the health-to-PsA transition with a comprehensive multiscale / multifactorial PsA model employing novel trustworthy AI-based analysis of multisource and heterogenous (i.a., in-depth health, environmental, genetic, behavioral) data. Project objectives iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA). PsA inflamation drivers Discover PsA inflammation drivers through AI-driven health, environmental and omics data mining. Role of mast cells Investigate the role of mast cells and features from non-invasive skin microvascular/joint imaging in inflammatory symptoms tracking. Personalised interventions Develop ICT-based personalised interventions to sustain or even improve quality-of-life. Co-creative ecosystem Co-create the iPROLEPSIS ecosystem with key stakeholders, following ethical, inclusive and trustworthy AI principles. Digital biomarkers Develop and validate objective digital biomarkers for tracking inflammatory symptoms and disease activity. Trustwothy AI models Build trustworthy AI models for personalised PsA risk prediction, early diagnosis and high disease activity prognosis. Digital health ecosystem Develop and clinically validate the iPROLEPSIS digital health ecosystem to empower persons with/at risk of PsA and healthcare professionals. Work packages The 6 Work Packages of the project will bring together various and complementary expertise from consortium partners. WP1 WP2 WP3 WP4 WP5 WP6 Work Package 1: Management and coordination WP1 is dedicated to project management and coordination aiming to enable a smooth project workflow; Ensure optimal contractual, administrative, financial, scientific, technical, IP and innovation management; Assure project quality and safeguard ethics, regulatory compliance and proper data management. Work Package 2: Knowledge mining, foundation and participatory design WP2 aims to create a foundational body of knowledge concerning PsA, associated conditions and inflammation; Identify, retrieve and curate datasets relevant to R&D activities of the project; Identify user needs and effectively engage with key stakeholders for steering research questions and co-creating the iPROLEPSIS digital care tools; Establish and monitor practices for ensuring adherence of iPROLEPSIS AI-driven components to trustworthy AI principles. Work Package 3: Research on PsA inflammation drivers and monitoring WP3 is dedicated to identify drivers related to PsA and associated inflammation leveraging new and existing multi-source health relevant data; Develop smartphone/wearable-based digital biomarkers (dBMs) for assessing PsA inflammatory symptoms; Shed light on changes in the joints and skin microvasculature related to PsA and the role of mast cells in associated inflammation; Through data fusion, develop a multiscale/multifactorial PsA model, emphasising on the prediction of the transition of high-risk individuals and PsO patients to PsA and of PsA patients to advanced inflammatory state. Work Package 4: Development of the iPROLEPSIS digital health ecosystem for personalised preventive care WP4 will technically specify the iPROLEPSIS ecosystem and set up a robust data management infrastructure and DevOps/MLOps platforms; Through an agile approach, develop the iPROLEPSIS minimum viable products (MVPs) for personalised PsA care including: 1) the patient app incorporating (dBM-based)PsA monitoring, knowledge, targeted interventions and tailored AI-driven lifestyle recommendations, 2) the serious gaming suite for health and wellness, 3) the app for HCPs allowing them to remotely monitor patients and view predictions on their course. Work Package 5: Clinical studies WP5 will develop the study protocols and carry out the process for their timely approval by concerned bodies; Set up a system for coordinating recruitment and efficiently managing clinical data and reporting; Organise and conduct four clinical studies: two multicentre prospective cohort studies for discovery and validation of PsA inflammation drivers and digital biomarkers, one observational study on PsA and changes in the joints and skin microvasculature, and one multicentre proof-of-concept randomised controlled trial (RCT) evaluating the effectiveness of the iPROLEPSIS digital care tools. Work Package 6: Dissemination, communication and exploitation WP6 will maximise visibility of the project and its outcomes and facilitate knowledge exchange while engaging a wide network of stakeholders; Develop PsA-related educational content; Set out a roadmap for regulatory approval of the iPROLEPSIS digital tools; Perform a thorough socio-economic/market analysis and develop concrete joint/individual exploitation plans. PROJECT VISION

We welcome your comments or questions about iPROLEPSIS project!​ Feel free to contact us by filling in the form to submit your comments or questions.​ Project coordinator Prof. Leontios Hadjileontiadis Project Coordinator Aristotle University of Thessaloniki Contact us We welcome your comments or questions about iPROLEPSIS! Please contact us by filling in the form below to submit your comments or questions. Ask your question or write a comment First name Last name Email Write a message I have read and agree to the Privacy policy SUBMIT Thanks for submitting! Please note that we will not give you medical advice. To discuss symptoms or conditions, please contact your physician or other health care provider.

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search Quizzes What is psoriatic arthritis? Take a Quiz What are the symptoms of psoriatic arthritis? Take a Quiz How is psoriatic arthritis treated? Drug treatments Take a Quiz How is psoriatic arthritis treated? Self-care and lifestyle Take a Quiz How will psoriatic arthritis affect me? Sleep and Fatigue Take a Quiz How will psoriatic arthritis affect me? Relationships and Family Planning Take a Quiz What causes psoriatic arthritis? Take a Quiz How is psoriatic arthritis diagnosed? Take a Quiz How is psoriatic arthritis treated? Non-pharmacological treatments Take a Quiz How will psoriatic arthritis affect me? Work Take a Quiz How will psoriatic arthritis affect me? Emotional wellbeing Take a Quiz

Learn more about international events for psoriatic arthritis. Choose the event and book the date. Upcoming and past events Athens Digital Health Week 2026 Feb 16, 2026, 9:00 AM – Feb 20, 2026, 4:00 PM Athens, Athens, Greece More info Details iPROLEPSIS 7th Plenary meeting Dec 09, 2025, 9:00 AM – Dec 10, 2025, 4:00 PM Lisbon, Lisbon, Portugal More info Details IEEE HealthCom 2025 Oct 21, 2025, 9:00 AM – 7:30 PM Abu Dhabi, United Arab Emirates More info Details HLTH Event 2025 Oct 19, 2025, 9:00 AM – Oct 22, 2025, 6:00 PM Las Vegas, Las Vegas, NV, USA More info Details GRAPPA Annual Meeting 2025 Jul 10, 2025, 11:00 AM – Jul 12, 2025, 8:00 PM Bogota, Colombia More info Details iPROLEPSIS 6th Plenary meeting May 13, 2025, 11:00 AM – May 14, 2025, 5:00 PM Oxford, UK More info Details 7th Polythematic Panhellenic Congress of Autoimmune Diseases, Rheumatology and Clinical Immunology Mar 28, 2025, 10:00 AM – Mar 30, 2025, 8:00 PM Portaria, Pelion More info Details Health Data Summit 2025 Mar 19, 2025, 9:00 AM – Mar 20, 2025, 7:00 PM The EGG, Brussels, Belgium More info Details iPROLEPSIS 5th Plenary Meeting Dec 02, 2024, 7:00 AM – Dec 03, 2024, 5:00 PM Athens, Greece More info Details DSAI 2024 Nov 13, 2024, 7:00 AM – Nov 15, 2024, 5:00 PM Khalifa University, Abu Dhabi, United Arab Emirates (UAE) More info Details PhD Open Days 2024 - 10th edition Nov 05, 2024, 7:00 PM – 11:00 PM Lisbon, Portugal More info Details How to communicate about and disseminate project results under Horizon Europe Cluster 1 ‘Health’ and Horizon 2020 Oct 24, 2024, 12:00 PM – 1:00 PM GMT+3 Webinar More info Details 16th Panhellenic EPEMY Conference Oct 05, 2024, 8:00 AM – Oct 06, 2024, 6:00 PM Ioannina, Greece More info DETAILS Psoriatic Arthritis Awareness Day Sep 28, 2024, 8:00 AM – 11:50 PM Virtual More info DETAILS European Researchers’ Night Sep 27, 2024, 8:00 AM – 7:40 PM Lisbon, Portugal More info DETAILS InnoHealth Forum 2024 Sep 20, 2024, 8:00 AM – Sep 21, 2024, 6:00 PM Larissa, Greece More info DETAILS IEEE EMBC 2024 Jul 15, 2024, 8:00 AM – Jul 19, 2024, 6:00 PM Orlando, Florida, USA More info DETAILS iPROLEPSIS 4th Plenary meeting Jul 01, 2024, 8:00 AM – Jul 02, 2024, 6:00 PM Munich, Germany More info DETAILS Load More

< BACK European Researchers' Night Sep 30, 2024 Engaging Communities through Science Bárbara Ramalho, Hugo Escobar, and Marta Vicente from FMH/IST-ULisboa presented the iPROLEPSIS Games and the iPROLEPSIS project at the European Researchers' Night in Oeiras, Portugal. This event, part of the "Science for Everyone (SCIEVER) – Inclusion and Sustainability" initiative, aimed to engage the public with scientific advancements. Researchers from various fields participated, sharing their work through interactive presentations, live demonstrations, and diverse activities, fostering a stronger connection between science and the community. The event unerlined the importance of making scientific research accessible to all. 1/4 PREVIOUS NEXT

< BACK Patient Voices in Research: Elaine’s Das Cheppo Journey with iPROLEPSIS Mar 4, 2025 A Patient’s Perspective: Elaine’s Journey with iPROLEPSIS Elaine Das Cheppo has been living with psoriatic arthritis for 25 years . Like many others, her diagnosis was delayed, making treatment more challenging in the early years. When her rheumatologist asked if she would like to take part in the iPROLEPSIS project , she did not hesitate. "I struggled in the beginning to understand why I was experiencing so much joint pain. By participating in this study, I hope to help future generations get a diagnosis faster than I did." The Role of Patient Partners in iPROLEPSIS Elaine is a patient partner in iPROLEPSIS, working alongside researchers to improve psoriatic arthritis care. She finds the co-creation sessions particularly insightful, offering her a behind-the-scenes look at how digital health solutions are developed. "It’s interesting to see how new technology is being used to improve diagnosis and treatment. These innovations could help people avoid unnecessary doctor visits and manage their condition more effectively." A Renewed Sense of Purpose For Elaine, being part of iPROLEPSIS is not just about contributing to research—it’s also about personal fulfillment . "For someone who has been retired for quite some time, it’s rewarding to have a new goal and interest in life. Being part of this project gives me a way to make a difference." Watch Elaine’s full story here: 1/1 PREVIOUS NEXT

< BACK Patty de Groot Discusses Digital Biomarkers in Rheumatology Podcast Jan 10, 2025 Exploring the Future of Digital Biomarkers in Rheumatology Patty de Groot from Erasmus MC recently appeared on the Digital Rheumatology Network podcast on Spotify, where she shared her insights on the role of digital biomarkers in rheumatology care. In this engaging conversation, Patty discusses the potential of digital tools, including findings from the iPROLEPSIS project, to improve early diagnosis, personalise treatment, and enhance patient care. She also talks about the use of design-thinking approaches to optimise healthcare workflows and the challenges of integrating digital innovations in clinical practice. Listen to the full podcast episode to learn more about how digital biomarkers are transforming rheumatology care and the future of healthcare innovation. 🎧 Listen here 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Presented at EIT Health Morning Health Talk in Athens Jun 5, 2025 Co-Creating Health Innovation Ecosystems: Empowering Providers and Citizens Beyond Financial Incentives On June 2, 2025, the iPROLEPSIS project was presented at the 1st Morning Health Talk – Greece , part of the EIT Health Morning Health Talks series. The event, titled “Co-Creating Health Innovation Ecosystems: Empowering Providers and Citizens Beyond Financial Incentives” , was organised by EIT Health Greece and hosted at the National Documentation Centre in Athens. Vasileios Charisis from Aristotle University of Thessaloniki (AUTH) presented an overview of iPROLEPSIS, developing a novel personalised digital care ecosystem for people with Psoriatic arthritis (PsA). The session brought together a diverse group of participants from across the health innovation landscape, including: EIT and EIT Health Greece representatives European Digital Innovation Hubs – Health Hub European Network of Living Labs Digital health consultants from the Greek Ministry of Digital Governance Public and private hospitals Private health insurance companies, homecare providers, and telemedicine companies The event offered valuable opportunities for sharing perspectives, building connections, and exploring collaborative strategies for the future of healthcare innovation. IMG_4494_edited.jpg 20250602_111815.jpg IMG_4499.jpg IMG_4494_edited.jpg 1/4 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Key Facts keyfacts 1 Understanding Psoriatic Arthritis Learn what psoriatic arthritis is, how it’s connected to psoriasis, what symptoms to look out for, how it’s diagnosed, and how to recognise a flare. f1.1 f1.2 See related Handbook section See related Handbook section See related Handbook section See related Handbook section See related Handbook section f1.3 f1.5 F1.4 keyfacts 2 Managing Psoriatic Arthritis: Treatments and Lifestyle Learn how psoriatic arthritis is treated through medications, non-pharmacological treatments, and everyday lifestyle choices that support health and wellbeing. See related Handbook section See related Handbook section See related Handbook section See related Handbook section See related Handbook section f2.1 f2.2 f2.3 f2.4 f2.5 keyfacts 3 Living with Psoriatic Arthritis Everyday tips for balancing work, improving sleep, managing fatigue, and supporting mental wellbeing. f3.1 See related Handbook section See related Handbook section See related Handbook section See related Handbook section f3.2 f3.3 f3.4 key facts 4 Intimacy, Reproductive Health and Family Life Understanding how psoriatic arthritis may affect relationships, sexual and reproductive health, and family planning decisions. See related Handbook section See related Handbook section See related Handbook section See related Handbook section f4.1 f4.2 f4.3 f4.4

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Handbook Intimacy, Reproductive Health and Family Life Handbook How will psoriatic arthritis affect me? RELATIONSHIPS AND SEX Psoriatic arthritis can present a number of challenges in a relationship, namely: reduce your enjoyment of sex and other activities you share with your partner; affect your mood and self-esteem; impact your ability to contribute to household and family related duties; lead to financial worries if your condition affects your ability to work. Although your relationship may change because of psoriatic arthritis, you should remember that most couples go through phases in their relationship that are more or less positive, depending on a number of factors such as stress, work-life balance, or other health conditions. See related Key Facts section h4.1 h4.3 Talking to your partner about any changes or challenges you may be facing is a great way to improve communication in the relationship and arrive at solutions to please both of you. If you are not in a relationship and worry about how your condition may affect your prospects of finding a romantic partner, especially if you have visible signs of the condition, keep in mind that most relationships develop gradually and that shared interests are more important than physical considerations. While sex will not make your psoriatic arthritis worse, it can sometimes be painful when you move an affected joint. Besides the physical aspect, psoriatic arthritis may decrease your sex drive, affect your self- confidence, or make you feel less attractive. Psoriatic arthritis can sometimes lead to a dry vagina, and thus to uncomfortable sex. If this is the case, water-based lubricants can help you and/or your partner. Oil-based lubricants may irritate your skin or damage condoms. To help you overcome difficulties with sex, you should: talk openly with your partner about your physical and/or emotional concerns; keep active as physical exercise can help you strengthen your muscles and support your joints; take painkillers approximately one hour before having sex to minimise pain; try different positions and use cushions, pillows, or furniture to support your body; remember that there are multiple ways to achieve sexual satisfactions, such as kissing, caressing, mutual masturbation, oral stimulation, or even sex aids such as vibrators. See related Key Facts section FERTILITY, PREGNANCY, AND BREASTFEEDING If you are planning to start a family, you should discuss your treatment plan with your rheumatologist, as some medications are not safe in pregnancy. It is completely normal to feel concerned about the effect of your condition on your ability to start a family. People with arthritis may take slightly longer to become pregnant. It is best to try for a baby when your condition is not very active. There is a genetic contribution to psoriatic arthritis, that is, the presence of certain genes makes a person more likely to develop the condition. However, this is not a strictly hereditary condition. There are many factors involved in the development of psoriatic arthritis, not just the genes inherited from parents. Therefore, in the vast majority of cases the chances of passing it on to your children are relatively low. FERTILITY In women, there is no evidence to support that psoriatic arthritis affects fertility (51). However, a recent study indicated that untreated inflammatory arthritis, such as psoriatic arthritis, may decrease male fertility (52). In both women and men, fertility does decrease with age or may be affected by other health conditions. h4.2 Therefore, some people living with psoriatic arthritis will need fertility treatments. If your psoriatic arthritis is under control, there should be no problem to initiate fertility treatments. Discuss any plans for fertility treatments with your rheumatologist. They can offer specific advice, review your treatment plan, and liaise with the medical team responsible for your fertility treatment. See related Key Facts section PREGNANCY AND BREASTFEEDING Discuss your plans to start a family with your rheumatologist so that your treatment plan can be adjusted. If you become pregnant unexpectedly, talk to your rheumatologist as soon as possible. All women get aches and pains during pregnancy. As the baby grows, you may feel additional strain on some of your joints, especially on your hips and knees. While there is not a lot of information on the effects of pregnancy in psoriatic arthritis, studies have shown that the majority of women living with rheumatoid arthritis experience some form of symptom improvement during pregnancy. However, some women will have a flare after giving birth. Psoriatic arthritis usually does not affect delivery and you can still give birth through your vagina. If you are considering a caesarean, you should discuss this with your doctors (rheumatologist and obstetrician). It may be necessary to stop some of your medications before the surgery. You should continue anti-rheumatic drugs that are safe in pregnancy during pregnancy and breastfeeding. This will reduce your chances of any complications during pregnancy and will make flares less likely after giving birth. Many mothers feel sad, tearful, or anxious in the first two weeks after having a baby. However, if these symptoms last for longer or start later on, you may have post-natal depression, which affects 1 in 10 women after giving birth. It is important to seek medical help if you feel this way. See related Key Facts section h4.4 Remember that you are not alone. If you need extra support, please speak to your GP or Health Visitor. More information can be found below: NHS Mental Health Services https://www.nhs.uk/nhs-services/mental-health-services/ NHS Postnatal Depression https://www.nhs.uk/mental-health/ conditions/post-natal-depression/overview/ Be kind to your joints and your mind. See related Key Facts Previous page Next page