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The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalized digital care ecosystem. iPROLEPSIS is a s olution for psoriatic arthritis The iPROLEPSIS project is where psoriatic arthritis inflammation is explained through multi-source data analysis guiding a novel personalised digital care ecosystem. ABOUT CONSORTIUM CONTACT US October 2025 TODAY Mon Tue Wed Thu Fri Sat Sun 29 30 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Day (1/4) HLTH Event 2025 +1 more 20 Day (2/4) HLTH Event 2025 +1 more 21 Day (3/4) HLTH Event 2025 +1 more +2 more 22 Day (4/4) HLTH Event 2025 +1 more 23 24 25 26 27 28 29 30 31 1 2 3 4 5 6 7 8 9 Upcoming events Psoriatic Arthritis (PsA) is a chronic progressive inflammatory disease affecting 1-2% of the general population, while manifesting in up to 30% of people with psoriasis (PsO). Project vision and impact iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with PsA. The goal of iPROLEPSIS is to propose a novel ecosystem that involves Real World Data (RWD) collection mechanisms and a powerful decision support system to provide new knowledge for the key actionable factors that affect the health-to-PsA transition, adopting a multiscale/ multifactorial approach, so, with the use of xAI-based models, to offer an efficient, effective, and clinically validated personalised digital care ecosystem for PsA patients. DISCOVER MORE Project objectives and work packages iPROLEPSIS consortium works on 7 ambitious key objectives in the field of Psoriatic Arthritis (PsA) and has 6 Work Packages of the project that will bring together various and complementary expertise from consortium partners. DISCOVER MORE About project 15 Partners 9 Countries 48 m Project duration € 6,4M Total budget The core activity domains Establishment • The foundation for the project’s research activities is laid by means of an extensive exploration of the available literature and data and the design of the clinical data collection and validation studies; • Participatory design supporting the development of a user-oriented ecosystem of solutions will be employed to establish a framework for trustworthy AI-based R&D. Validation • The design and implementation of the clinical studies that will collect research data, validate the inflammatory symptoms digital biomarkers in individuals at risk of PsA and PSO patients, and evaluate the efficacy of the digital care tools with respect to prevention of inflammation exacerbation. Research and development • Research on multimodal data to reveal key PsA inflammation drivers, provide digital biomarkers of PsA inflammatory symptoms, and explore the effect of PsA on the joints and skin microvasculature, as well as the role of mast cells in PsA transition; • Synthesise the outcomes into a multiscale/multifactorial model of the health-to-PsA transition; • Deliver the integrated iPROLEPSIS digital health ecosystem comprising tools for personalised preventive PsA care, to empower patients and HCPs. Contact us We welcome your comments or questions about iPROLEPSIS project! CONTACT US

Clinical experts Laura Coates Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Position NIHR Research Professor What is your role in iPROLEPSIS? Lead for WP5 (clinical studies) What are your main activities in the project? I oversee all of the clinical studies within the consortium. What is your motivation? I am a rheumatologist who has worked in research in psoriatic arthritis for around 20 years. My interest is in improving outcomes for people living with psoriatic arthritis and I believe that work in this project can help us to predict, monitor and understand the disease better in day to day clinics.

Dissemination and communication Kristina Leipuviene SmartSol SIA Position Project manager What is your role in iPROLEPSIS? Dissemination/Communication lead What are your main activities in the project? Leading and planning communication and dissemination activities. SmartSol team also supports networking and clustering with stakeholders. What is your motivation? As leaders of WP6, SmartSol aims to increase awareness of iPROLEPSIS and make it accessible to everyone. We focus on sharing information, raising awareness about psoriatic arthritis, and making a lasting impact through thoughtful planning and engagement with the public.

Meet our people Meet the people behind the iPROLEPSIS project. Coordination About team Software development About team Clinical experts About team Ethics, legal, exploitation About team Data sience About team Dissemination and communication About team

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search How is psoriatic arthritis treated? Drug treatments See related Handbook section PREVIOUS NEXT

< BACK iPROLEPSIS presented at the 2024 HIMSS European Health Conference Jun 11, 2024 Showcasing AI-Based Solutions for Psoriatic Arthritis Care Our project partner, PLUX Biosignals , participated in the 2024 HIMSS European Health Conference and Exhibition , where they showcased the innovative work of the iPROLEPSIS project, developing a novel personalised digital care ecosystem for people with psoriatic arthritis. The 2024 HIMSS European Health Conference and Exhibition was a major event for the European digital health community, bringing together approximately 2,500 healthcare executives, practitioners and professionals from 84 different countries in Rome. Held from May 29 to 31, the conference showcased the latest advancements in healthcare technology and provided a platform for critical discussions on the future of digital health in Europe and worldwide. HIMSS24 Europe addressed the region’s strategic initiatives in digital health, including the AI Act and the European Health Data Space, which aim to position Europe as a leader in digital health. HIMSS_iPROLEPSIS (2).jpg HIMSS_iPROLEPSIS (1).jpg HIMSS_iPROLEPSIS (2).jpg 1/2 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search What is psoriatic arthritis? See related Handbook section PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search What are the symptoms of psoriatic arthritis? See related Handbook section PREVIOUS NEXT

Join iProlepsis project for the psoriatic arthritis community. Share your experience, expertise and observations, observations Community Information will be available soon.

< BACK Highlights from IFPA 2024 Jun 28, 2024 iPROLEPSIS at IFPA 2024 The 7th World Psoriasis & Psoriatic Arthritis Conference, held on June 27-29, 2024, brought together leading experts and researchers to discuss the latest advancements in psoriasis and psoriatic arthritis. Dr Laura Coates from the University of Oxford discussed the potential to prevent psoriatic arthritis, including the work being done in iPROLEPSIS and HIPPOCRATES IMI. 1/6 PREVIOUS NEXT

< BACK Psoriatic Arthritis Awareness Day Sep 28, 2023 iPROLEPSIS project is joining to celebrate the Psoriatic Arthritis Awareness Day This September 28th, the iPROLEPSIS project is joining to celebrate Psoriatic Arthritis Awareness Day, dedicated to raising awareness of the painful inflammatory disease often linked with psoriasis. iPROLEPSIS is a research and innovation initiative. The project uses cutting-edge technology and AI to develop a novel personalised digital care ecosystem for people with Psoriatic Arthritis. Join us on September 28th and help reshape the future of Psoriatic Arthritis care! News & Events iPROLEPSIS - events.png News & Events iPROLEPSIS - events.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Project Presented at HUMAN Lab Meetup Jul 15, 2024 Enhancing Learning Through Innovative Serious Games and Digital Interventions On 8 July 2024, the HUMAN Lab meetup was organised by Universidade de Lisboa (Instituto Superior Técnico, IST). During the event, Bárbara Ramalho and Hugo Escobar from FMH/IST-ULisboa presented the iPROLEPSIS project and the iPROLEPSIS Games. They discussed the project's main goals, motivations, and key milestones, providing insights into their roles in the design and development of serious games. The presentation also addressed the expected outcomes of the project, emphasising how these innovative tools are designed to enhance learning experiences and offer effective digital interventions. 1/3 PREVIOUS NEXT