< BACK iPROLEPSIS Presented at Health Data Summit 2025 Mar 27, 2025 Showcasing practical strategies for high-quality data mapping and harmonisation At Health Data Summit 2025 , organised by the European Institute for Innovation Through Health Data (i~HD) on March 18–19 in Brussels , the iPROLEPSIS project was presented by Thanos Vidakis from AINIGMA Technologies . The presentation was part of the session titled: "Advanced Strategies and Tools for Ensuring High-Quality Data During Data Mapping". It focused on how iPROLEPSIS uses the OMOP Common Data Model (CDM) and OHDSI tools to harmonize health datasets from various sources. By applying coding standards such as SNOMED , the project ensures consistency and interoperability across data systems. The talk also highlighted recent hands-on workshops with data experts , during which real-world data was mapped to the OMOP model and underwent quality checks . These steps are essential in delivering analytics-ready health data — a key goal of the project. iPROLEPSIS continues to support high standards in digital health research by promoting data quality, standardisation, and collaboration across partners. 1/2 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search What is psoriatic arthritis? See related Handbook section PREVIOUS NEXT

< BACK The Spy and Zen Forest Exergames as Sources of Digital Biomarkers for Psoriatic Arthritis: A Co-Design Paradigm Aug 24, 2026 New iPROLEPSIS publication presents co-designed exergames to support therapeutic engagement in psoriatic arthritis A new iPROLEPSIS publication presents two exergames co-designed with patients and clinicians to support therapeutic engagement in psoriatic arthritis care. The study introduces The Spy and Zen Forest , exergames that embed therapeutic movements into game mechanics. Psoriatic arthritis requires ongoing physiotherapy and exercise for joint health, but traditional approaches face challenges: patients experience low consistency in participation, high costs, and high dropout rates. The research involved co-design with 29 participants, including patients diagnosed with psoriatic arthritis, clinicians, researchers, and technical experts. This collaborative approach ensured the games align with clinical goals, address patient needs, and support safe and effective rehabilitation. In The Spy, players assume the role of a secret agent completing missions that require dynamic full-body movements targeting coordination, mobility, balance, strength, and flexibility. Zen Forest emphasizes slow, controlled movements inspired by Pilates and yoga, designed to improve flexibility, relaxation, and body awareness. The publication explores how exergames can serve as sources of digital biomarkers – measurable data collected through gameplay including movement quality, repetition patterns, and task performance – that may help researchers monitor patient progress and disease patterns. Read the full publication: https://ieeexplore.ieee.org/document/11552850 iPROLEPSIS_The Spy and Zen publication.png iPROLEPSIS_The Spy and Zen publication.png 1/1 PREVIOUS NEXT

< BACK "The Kite" Breathing Serious Game: Agile Co-Design for Psoriatic Arthritis Jul 31, 2024 Enhancing PsA Management through Innovative Breathing Exercises and Game-Based Therapy Latest research initiative under the iPROLEPSIS project: “The Kite” Breathing Serious Game: Agile Co-Design for Psoriatic Arthritis presented at IEEE MELECON 2024. This study is part of a broader effort to develop and validate innovative digital biomarkers for managing Psoriatic Arthritis (PsA) through the Artificial Intelligence-Personalised Game Suite (AI-PGS). Abstract: Serious Games (SGs) have the potential to provide clinical care and enhance patients’ quality of life, while incorporating an element of entertainment. As part of the iPROLEPSIS Horizon Europe project, we introduce two Sensorimotor Art games designed as SGs to assist Psoriatic Arthritis (PsA) patients in managing their symptoms. These SGs provide a platform for self-expression and pain relief through engaging in rhythmic puzzle activities. The co-design process for the proposed Sensorimotor Art games followed an agile methodology, involving 14 experts (including clinicians, researchers, and game developers), to gather feedback on game requirements, storyboards, and mechanics. From the thematic analysis of the transcribed discussion, four main themes emerged, namely: Clinical value (Theme 1), Motor skills and adaptation (Theme 2), Creative engagement (Theme 3), and Feedback and future directions (Theme 4). Clinical value underlines the therapeutic benefits of Sensorimotor Art games for pain distraction and emotional well-being. Motor skills and adaptation focus on hand/finger use and adapting games for older patients. Creative engagement emphasizes fostering creativity, a positive environment, and goal achievement. Finally, feedback and future directions highlight the importance of continuous feedback and occupational therapists’ involvement in coming sessions. The development of Sensorimotor Art games lays the groundwork for digital interventions to alleviate psychological distress and improve fine motor symptoms in PsA patients. At the same time, these SGs can also provide insights to healthcare providers and policymakers for developing future digital solutions tailored to PsA patients. Read the full publication: https://zenodo.org/records/13141465 IEEE_MELECON_2024 .pdf Download PDF • 1.33MB 1/1 PREVIOUS NEXT

< BACK 6th iPROLEPSIS Plenary Meeting Held in Oxford May 15, 2025 Partners Shared Progress and Plans for the Future The iPROLEPSIS consortium came together on 13–14 May 2025 for its 6th Plenary Meeting , hosted by the University of Oxford in the beautiful city of Oxford, UK. The two-day meeting covered updates on various parts of the project, including system development, clinical studies, data harmonisation, and user needs. It was a great opportunity for partners to share progress, discuss challenges, and align on next steps. Workshops helped address open issues and refine priorities for the coming months. On the first day, the consortium also welcomed feedback from the External Advisory Board , offering helpful guidance on recent developments. A warm thank you to the University of Oxford for hosting and to all participants for the active and constructive discussions! IMG_9529.jpg IMG_9431.jpg IMG_9527.jpg IMG_9529.jpg 1/8 PREVIOUS NEXT

< BACK iPROLEPSIS Games Presented at Centro Neurológico de Torres Vedras Jul 21, 2026 The visit offered an opportunity to present the iPROLEPSIS Games and discuss the project’s work with the centre’s team On 8 July 2026, the Faculdade de Motricidade Humana from University of Lisbon team visited the Centro Neurológico de Torres Vedras in Portugal to present the iPROLEPSIS Games. The visit provided an opportunity to introduce the iPROLEPSIS games, share the team’s work and exchange insights with the centre’s staff. The iPROLEPSIS Games are being developed as part of the project’s work on digital tools for people with psoriatic arthritis. cns4.png cns2.jpeg cns1.jpeg cns4.png 1/3 PREVIOUS NEXT

< BACK State-of-the-art analysis and datasets landscape Nov 6, 2023 Initial review, focusing on the state-of-the-art literature and existing datasets in the field of PsA Psoriatic arthritis is a chronic immune-mediated inflammatory arthritis occurring in patients with PsO. The disease manifestation can be heterogeneous between subjects, and the resulting musculoskeletal impairment can interfere with physical function as well as the quality of life of patients. In a collaborative effort, the iPROLEPSIS partners completed an initial extensive review, focusing on the state-of-the-art literature and existing datasets in the field of PsA, with a special focus on flare dynamics. The primary goal was to enhance the understanding of PsA by investigating disease symptoms, factors associated with flares, and markers for disease development and monitoring. The insights gained from the literature will provide background for various aspects of iPROLEPSIS research, such as investigating PsA inflammation drivers and monitoring, developing the iPROLEPSIS digital health ecosystem for personalised preventive care, and conducting clinical studies. Moreover, various multi-source datasets have been identified that can potentially yield valuable information for the discovery of PsA inflammation drivers and the development of novel digital biomarkers and predictive models for disease monitoring and progression prognosis. The identified datasets will be assessed for relevancy and usability, retrieved, harmonised and curated. These datasets and predictive models will contribute to the research on PsA monitoring and inflammation drivers. In addition, the identified existing datasets will also guide the development of the Lifestyle AI-driven recommendation system and the Serious Games. The key takeaways are: Fatigue, pain and stiffness are commonly reported symptoms in PsA Flare may be triggered by alterations in mood, stress, sleep, bowel movements, and environmental factors Flare may affect mood, stress, sleep, bowel movements, physical activity and fine motor skills Certain symptoms of PsA may also trigger or be triggered by flare Clinical measurements of PsA symptoms and hypothesized flare associated factors, mainly include questionnaires The use of smartphone and wearables to monitor physical activity (mainly through accelerometer data), fine motor skills (through keystroke dynamics), heart rate, heart rate variability have also shown potential to measure PsA symptoms and hypothesized flare associated factors Electrography techniques can also be used in the assessment of certain symptoms and flare associated factors Genetic factors may contribute to development of PsA, pain perception and response to treatment. Gut microbiome may be involved in PsA. MCs in skin are suggested to play a role in skin inflammation Monitoring of PsA can be achieved through clinical examination for inflamed joints, enthesitis dactylitis, nail and skin and subsequent calculation of relative indices and composite scores Imaging-based approaches including images obtained from smartphones and optoacoustics represent a complementary or alternative approach to clinical assessment Data-driven models can serve to find predictive relations even when the underlying mechanisms are poorly understood or are too complex. Recommendations and SGs present a potential approach to modify and improve diet and physical activity Besides diet and physical activity, SGs can also address other aspects of disease, including medication adherence, social support, cognition, breathing, biological and neural function OMOP CDM was opted to be used for standardising the datasets Future steps include an update on state-of-the-art literature and measurement tools on the topics covered by initial research and the identification of new datasets that could be relevant for data-driven models. News & Events iPROLEPSIS - news.png News & Events iPROLEPSIS - news.png 1/1 PREVIOUS NEXT

< BACK Workshop at PETRA 2024: Advancing Personalised Health Through Multimodal Sensing and Innovative Environments Jan 25, 2024 Exploring the Future of Healthcare: AI-PROGNOSIS and iPROLEPSIS Projects Collaborate for Workshop on Human Health, Habits, and Behavior The workshop "AGENT - MultimodAl SiGnal Sensing/Analysis, Innovative Interactive Environments, and PersoNalized Behavioral Modeling for Improving QualiTy-of-Life" has been accepted in PETRA 2024! The workshop will be organised by the Centre for Research & Technology Hellas , Aristotle University of Thessaloniki , and Faculdade de Motricidade Humana in cooperation with the AI-PROGNOSIS and iPROLEPSIS projects. More info about the workshop: http://www.petrae.org/workshops/AGENT.html AI-PROGNOSIS is a Horizon Europe-funded project developing Artificial intelligence-based solutions for #Parkinson 's disease risk assessment and prognosis. iPROLEPSIS is a Horizon Europe-funded project developing a novel personalised digital care ecosystem for people with #Psoriatic #arthritis . The workshop aims to attract an interdisciplinary group of researchers involved in research related to early detection, assessment and monitoring of human health, habits and behaviour. The workshop will focus on novel technologies applied in real or virtual environments and aim to enhance the quality of daily living, especially for people with disabilities or patients suffering from chronic conditions. About PETRA 2024: PETRA (PErvasive Technologies Related to Assistive Environments) is a premier interdisciplinary conference focusing on computational and engineering approaches to enhance human performance and improve the quality of life. Join us in exploring the latest advancements in assistive technologies across various settings. More info: http://www.petrae.org/index.html Looking forward to an enriching exchange of ideas and knowledge at PETRA 2024! Banner1-2024.png Banner1-2024.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Newsletter No. 8 Apr 28, 2025 Latest News from iPROLEPSIS Welcome to the eighth edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter Issue No. 8_Apr 2025 .pdf Download PDF • 3.38MB 1/1 PREVIOUS NEXT

The consortium of iProlepsis project for psoriatic arthritis consists of 15 partners from 9 countries. Discover more about project by visiting our website. About consortium partners iPROLEPSIS project coordinator Aristotle University of Thessaloniki Consortium consists of 15 partners from 9 countries. iPROLEPSIS consortium partners

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search Psoriatic Arthritis Key Facts keyfacts 1 Understanding Psoriatic Arthritis Learn what psoriatic arthritis is, how it’s connected to psoriasis, what symptoms to look out for, how it’s diagnosed, and how to recognise a flare. f1.1 f1.2 See related Handbook section See related Handbook section See related Handbook section See related Handbook section See related Handbook section f1.3 f1.5 F1.4 keyfacts 2 Managing Psoriatic Arthritis: Treatments and Lifestyle Learn how psoriatic arthritis is treated through medications, non-pharmacological treatments, and everyday lifestyle choices that support health and wellbeing. See related Handbook section See related Handbook section See related Handbook section See related Handbook section See related Handbook section f2.1 f2.2 f2.3 f2.4 f2.5 keyfacts 3 Living with Psoriatic Arthritis Everyday tips for balancing work, improving sleep, managing fatigue, and supporting mental wellbeing. f3.1 See related Handbook section See related Handbook section See related Handbook section See related Handbook section f3.2 f3.3 f3.4 key facts 4 Intimacy, Reproductive Health and Family Life Understanding how psoriatic arthritis may affect relationships, sexual and reproductive health, and family planning decisions. See related Handbook section See related Handbook section See related Handbook section See related Handbook section f4.1 f4.2 f4.3 f4.4

Software development team Francisco Cardoso PLUX Position Software Developer What is your role in iPROLEPSIS? Monitoring Engineer What are your main activities in the project? I define SLIs/SLOs, design telemetry (metrics, logs, traces), build alerts and dashboards, run incident response/postmortems, and align data retention and security with compliance. What is your motivation? I’m motivated by making complex systems trustworthy. Turning real-time signals into fast decisions that reduce downtime and protect participants and data. Hugo Humberto Plácido da Silva PLUX Position Founder & Chief Innovation Officer What is your role in iPROLEPSIS? Principal Investigator representing PLUX. What are your main activities in the project? Internal management of the project at the board/administration level. Our team is making substantial contributions to the development of digital biomarkers (dBMs) that can be acquired using a smart belt. Furthermore, we are responsible for the iPROLEPSIS system orchestration, verification, and monitoring. What is your motivation? Psoriatic Arthritis (PsA) is a highly conditioning disease that currently affects a significant number of patients globally. Existing assessment and management methods are mostly bound to a clinical setting, involving complex protocols, therefore only of limited access to patients. For as long as I can remember, my work has been centered around purpose-driven innovations in the healthcare space; the possibility to explore novel dBMs as a way of improving the lives of PsA patients constitutes a once-in-a-lifetime opportunity and purpose like none other. Sofia Balula Dias Faculdade de Motricidade Humana Position Principal Investigator representing FMH partner What is your role in iPROLEPSIS? As Principal Investigator, I lead the design and development of a serious games-based intervention tool specifically tailored to support individuals living with Psoriatic Arthritis. What are your main activities in the project? Our multidisciplinary team is leading the development of the iPROLEPSIS serious games application to support Psoriatic Arthritis patients. Through co-creation with patients and collaboration across research, clinical, and design fields, we’re tailoring game mechanics and biofeedback features to meet real needs and preferences. Our work involves prototyping, testing, and refining therapeutic content designed to improve mobility, support pain management, reduce stress, and promote self-management, ultimately contributing to a more holistic and patient-centered approach to chronic care. What is your motivation? I am driven by the opportunity to improve the lives of PsA patients through non-pharmacological, technology-driven interventions. Serious games present an innovative and empowering method for symptom management and patient engagement. To date, there are no serious games specifically tailored to the needs of individuals with PsA, making this work both timely and impactful. Rodrigo Duarte Braga PLUX Position Research Collaborator What is your role in iPROLEPSIS? Systems Engineer What are your main activities in the project? I coordinate system orchestration, verification, and monitoring. I also lead the Smartbelt's technical development, from data acquisition and processing device data to building machine learning models. What is your motivation? Tackling complex challenges and developing innovative solutions and medical devices that create tangible value. Sérgio Lopes da Fonseca PLUX Position Project Manager What is your role in iPROLEPSIS? PLUX’s contribution to iPROLEPSIS management. What are your main activities in the project? Aligning timelines, deliverables, and resources across partners. I manage work-package commitments, budget and risks, and represent PLUX in steering and technical meetings to keep decisions action-oriented and on schedule. What is your motivation? To turn research into deployable, user-centred solutions. I’m driven by projects that measurably improve clinical workflows and patient outcomes—while creating a clear path from prototype to scalable product. iPROLEPSIS is a chance to do all three: integrate wearable biosignals seamlessly, prove value in real settings, and accelerate European med-tech competitiveness. Coordination Clinical Experts Data Science Software Development Ethics, Legal and Exploitation Dissemination and Communication