< BACK iPROLEPSIS Newsletter No. 12 Jul 22, 2026 Latest news from iPROLEPSIS Welcome to the twelfth edition of the iPROLEPSIS newsletter, where we share the latest updates and progress from the project. iPROLEPSIS project newsletter_Jul 2026_ Issue No. 12 .pdf Download PDF • 5.24MB iPROLEPSIS_newsletter 12.png iPROLEPSIS_newsletter 12.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS: updates on user research and co-creation Oct 17, 2023 Co-creation sessions for advancing the development of the mIPROLEPSIS app iPROLEPSIS active engagement with users through ongoing co-creation sessions helps to advance the development of the mIPROLEPSIS app, scheduled for delivery before January 2024. In October 2023, the project partner Erasmus MC (EMC) conducted a co-creation session with patient partners to assess the User Interface (UI) of the PDPID-app. The focus was on improving usability, ensuring users’ understanding of expectations and enhancing users’ engagement to minimise missing data. The project partner FACULDADE DE MOTRICIDADE HUMANA (FMH-ULISBOA), is also developing storyboards for the personalised gaming suite . Three co-creation sessions were conducted: one with healthcare professionals and two with patient partners. Project partners The Centre for Research and Technology Hellas (CERTH) and FACULDADE DE MOTRICIDADE HUMANA (FMH-ULISBOA), in collaboration with the clinical partners, worked on identifying movements for the video analysis that will be included in the iPROLEPSIS-PDPID study. Multiple hand gestures and fullbody movements were identified for further assessment. Main points: mIPROLEPSIS App’s general looks and UI were approved by the patient partners; Despite being a data-collection app for research purposes, patients emphasise the significance of reviewing their own data entries; Participants noted a need for enhanced visual cues regarding specific activities in the app. Main points: Personalised gaming suite Smart games meant for disease management need to be highly tailored to the capabilities of the patients; Patients view gaming as a form of relaxation, emphasising the importance of stress-free design; Patient partners expressed interest in the proposed gaming categories. 1/0 PREVIOUS NEXT

< BACK iPROLEPSIS presented at TeraMed Conference 2026 in Angola Apr 22, 2026 The project and the iPROLEPSIS Games were presented, highlighting their relevance for digital health innovation Filipa Magalhães from Faculdade de Motricidade Humana/ Instituto Superior Técnico presented the iPROLEPSIS project and the iPROLEPSIS Games at the TeraMed Conference 2026 , held on 16 April 2026 in Angola. The conference brought together various stakeholders to discuss the challenges and opportunities of implementing digital solutions in healthcare, particularly in the Angolan context. During the event, Filipa Magalhães presented the iPROLEPSIS project and the iPROLEPSIS Games , highlighting their objectives and innovative approach. Given the limited availability of psoriatic arthritis-related data in Angola and other African countries, she emphasised the project’s potential to support the development of digital health solutions through a gamified approach , especially in regions with one of the youngest populations in the world. The co-creation methodology used in the development of the iPROLEPSIS Games was also showcased as a strong example for developers, reinforcing the importance of involving users from the early stages in order to better address real needs and increase patient engagement. As part of the event, Filipa Magalhães also gave an interview to RTP Africa, where she discussed the complexity of psoriatic arthritis and explained how this led to the creation of different game categories addressing various symptoms within the iPROLEPSIS Games. The interview also highlighted the potential impact of digital health interventions in this area. Screenshot 2026-04-21 at 12.37.49.png WhatsApp Image 2026-04-17 at 20.32.00.jpeg Screenshot 2026-04-21 at 12.37.49.png 1/2 PREVIOUS NEXT

< BACK iPROLEPSIS digital ecosystem's architecture Oct 5, 2023 iPROLEPSIS ecosystem's architecture: a glimpse into technical progress One of the main objectives of the iPROLEPSIS project is to provide a digital health ecosystem to support healthcare professionals in disease screening, monitoring, and treatment while empowering individuals with/at risk of Psoriatic Arthritis with personalised insights and preventive interventions. In September 2023, the project’s technical partners introduced the first version of the iPROLEPSIS ecosystem architecture , including the initial technical specifications and product backlog. __________________ Amalia Ntemou from Netcompany-Intrasoft , consortium partner leading technical specification, system architecture and product backlog task within iPROLEPSIS, shares insights on the latest updates on the iPROLEPSIS ecosystem architecture. The first version of the iPROLEPSIS ecosystem's architecture and technical specifications has been defined. Can you explain the importance of this achievement in the project's development process? One of the main objectives of the iPROLEPSIS project is to provide a digital health ecosystem to support healthcare professionals in disease screening, monitoring, and treatment, while empowering individuals with/at risk of PsA with personalised insights and preventive interventions. The design of the architecture and the definition of functional and non-functional requirements are essential for the successful implementation of the iPROLEPSIS ecosystem as it constitutes a clear and comprehensive guide for partners’ development efforts. Various systems’ elements, components, connectors, processes and interactions are illustrated thereby enabling common understanding among project’s partners and adherence to common approaches and specifications that promote effective collaboration and delivery. A well-defined architecture with clear functional and non-functional requirements can be the basis for delivering sustainable solutions. What are the main components of the iPROLEPSIS digital ecosystem to be developed? The initial conceptual architecture of the iPROLEPSIS ecosystem consists of the miPROLEPSIS patient mobile app (including the embedded subcomponent/feature biAURA), the iPROLEPSIS healthcare professionals (HCP) web app , the cloud-based Data Management System , the AI-driven Lifestyle Recommendation Engine , the xAI-driven Models Engine and the Serious Games Suite . Finally, the operation of the entire system is supported by the Orchestration and Monitoring component . For whom is the iPROLEPSIS ecosystem specifically intended, and how does it cater to their unique needs? Patients are the primary users of the miPROLEPSIS patient app which is the tool for personalised disease monitoring. The miPROLEPSIS patient app operates as a tool for capturing data from sensors and wearable devices, as well as communicating feedback from the recommendation engine to the user. The miPROLEPSIS patient app incorporates additional applications/features (e.g., biAURA, keyboard etc.) for further monitoring of patients’ conditions, interventions and engagement hooks. Via the miPROLEPSIS HCP app, doctors and health care professionals are able to track their patients’ health status, review projections of the PsA progression, and utilise recommendations of optimised personalised suggestions towards a better management of PsA. Aggregated patients’ data about their health status, and outcomes of the xAI Models Engine are displayed intuitively and informatively to HCPs through dashboards. Doctors can monitor patients’ adherence to medical, dietary, and physical activity plans and issue warnings and notifications or adjust treatment regimens. In this way, accurate interventions are supported, while efficient and optimized management of PsA patients’ needs can be achieved and communicated to fellow colleagues and related stakeholders. What was the main focus while designing the iPROLEPSIS ecosystem architecture? The iPROLEPSIS digital health ecosystem serves as the enabler for personalised preventive care and the empowerment of citizens, patients and Healthcare Professionals (HCP). This emphasis on personalisation and empowerment guided the collection and definition of functional and non-functional requirements, as well as the internal architecture of components and technical specifications. Ultimately, these efforts led to the design of the ecosystem’s architecture. Have any methodologies been used in designing the iPROLEPSIS ecosystem architecture, and why is it important to use them? To organise the design and architecture of the iPROLEPSIS ecosystem, several established frameworks/methodologies were evaluated based on a thorough literature review in order to conclude to a framework that provides a holistic and comprehensive view of a software system’s architecture. Finally, we used a widely known methodology developed in 1995 by Kruchten , due to its ability to offer a structured approach to the system’s design, enabling multidisciplinary teams to represent different aspects of the system effectively and in detail. Utilising already established methodologies and following best practices, enhances efficiency, reduces risks, leads in better design decisions and contributes to overall success of the project. As the project progresses, how will the architecture and product backlog be refined and adapted during the development phases of the iPROLEPSIS? Development and establishment of the iPROLEPSIS digital health ecosystem is an ongoing process that runs approximately until the end of the project. Technical testing and verification of new versions of ecosystem’s components, as well as the monitoring of their performance and stability once released to users, have also been considered. The outcomes of development and monitoring processes will continuously populate the product backlog, representing the changing needs and priorities as the development of the components progresses. All updates and enhancements will lead to a refined version of the architecture and a fully operational iPROLEPSIS ecosystem. Stay tuned as we embark on this transformative journey towards a brighter future in Psoriatic Arthritis management! News & Events iPROLEPSIS - news.png News & Events iPROLEPSIS - news.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS presented to Eli Lilly in the Netherlands Nov 8, 2023 Presentation to Eli Lilly introduces iPROLEPSIS as the next step in personalised psoriatic arthritis care On the 7th of November 2023, Ilja Tchetverikov from CICERO Rheumatology presented the results and prospects of the DEPAR cohort and introduced iPROLEPSIS clinical studies to the representatives of Eli Lilly company in the Netherlands. DEPAR, Dutch south-west Psoriatic Arthritis Registry, is a registry set up by Cicero Rheumatology, a partnership of rheumatologists working in 15 different hospitals in the south-west of the Netherlands. DEPAR, with the participation of well over 900 patients, supports rheumatologists to gain insight into the treatment and course of psoriatic arthritis. The presentation highlighted iPROLEPSIS as a logical next step in the further development of DEPAR, emphasising the project’s vision and aim to explain psoriatic arthritis inflammation through multi-source data analysis, guiding to a novel personalised digital care ecosystem. Slide1.JPG Slide2.JPG Slide6.JPG Slide1.JPG 1/6 PREVIOUS NEXT

< BACK Developing Exergames for Psoriatic Arthritis using Agile Storyboarding and Game Design Processes Jun 27, 2024 Enhancing Mobility and Quality of Life through Agile Co-Designed Exergames for Psoriatic Arthritis We are pleased to announce our latest study, "Developing Exergames for Psoriatic Arthritis using Agile Storyboarding and Game Design Processes", presented at PETRA 2024. This research, a part of the Horizon Europe iPROLEPSIS project, focuses on creating Exergames to improve physical activity and well-being for individuals with Psoriatic Arthritis. Abstract Serious Games (SGs) offer significant potential in healthcare for disease assessment and intervention, enhancing patients’ quality of life. Exercise SGs, or Exergames, promote physical activity and mobility in a gamified environment, encouraging tailored exercises based on individual abilities and needs. Here, within the Horizon Europe iPROLEPSIS project that targets Psoriatic Arthritis (PsA), we describe the design process of Exergames to address PsA symptoms, including morning stiffness, impaired finger/hand and wrist functionality, and motor asymmetry. From a methodological point of view, the storyboarding technique was adopted to facilitate the visualization of the proposed Exergame scenarios, including the graphical user interface, interactive game elements, narratives, characters, and contexts related to the PsA condition. This approach has been implemented within an agile game development methodology, which includes gathering feedback early on to iteratively refine both the game ideas and prototype. Informed by the results of the game design via two agile sessions incorporating 25 participants (PsA patients, clinicians, technology developers, facilitators/observers), the current efforts are focused on developing the game prototypes and corresponding mock-ups, preparing them for upcoming clinical validation trials. The Exergames development lays the groundwork for an innovative framework to improve gross and fine motor symptoms in PsA patients. This framework could inform healthcare providers and policymakers about its potential inclusion in routine PsA management. Read more: https://dl.acm.org/doi/10.1145/3652037.3663939 Developing Exergames for Psoriatic Arthritis using Agile .pdf Download PDF • 1.70MB 1/1 PREVIOUS NEXT

< BACK Psoriatic Arthritis Awareness Day 2024 Sep 27, 2024 Advancing Psoriatic Arthritis Care with Technology and Research On 28 September, we celebrate Psoriatic Arthritis Awareness Day, a day dedicated to raising awareness about this condition and its impact on patients' lives. The iPROLEPSIS project is dedicated to improving our understanding and management of psoriatic arthritis. Did you know that psoriatic arthritis affects 112 out of 100,000 adults worldwide? This condition causes inflammation, pain, and fatigue, significantly affecting daily life. Therefore, finding better ways to monitor and manage it is important. PROLEPSIS-PDPID Study The iPROLEPSIS-PDPID study focuses on using smart devices and clinical data to develop new AI-driven models for personalised monitoring and flare prediction. This innovative approach seeks to empower patients by providing them with the tools they need to understand their condition better. miPROLEPSIS App A digital tool designed to help patients in tracking their condition. By collecting data from smartphones and smartwatches, the app offers insights into disease triggers and prognosis. This personalised information can help patients manage their symptoms more effectively, leading to improved health outcomes. Collaborative Efforts Conducted across four countries - the Netherlands, UK, Portugal, and Greece - the iPROLEPSIS project brings together experts and patients to transform the care of psoriatic arthritis. Through collaboration, the project aims to develop innovative solutions that cater to the needs of patients, enhancing their quality of life. Join Us in Raising Awareness As we celebrate Psoriatic Arthritis Awareness Day, we invite you to join us in promoting better management and understanding of psoriatic arthritis. Together we can make a difference in the lives of those living with this condition. https://video.wixstatic.com/video/981fae_8ec1c0b1c7f9418eb7cfa55dd1bd3509/720p/mp4/file.mp4 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Presented at EIT Health Morning Health Talk in Athens Jun 5, 2025 Co-Creating Health Innovation Ecosystems: Empowering Providers and Citizens Beyond Financial Incentives On June 2, 2025, the iPROLEPSIS project was presented at the 1st Morning Health Talk – Greece , part of the EIT Health Morning Health Talks series. The event, titled “Co-Creating Health Innovation Ecosystems: Empowering Providers and Citizens Beyond Financial Incentives” , was organised by EIT Health Greece and hosted at the National Documentation Centre in Athens. Vasileios Charisis from Aristotle University of Thessaloniki (AUTH) presented an overview of iPROLEPSIS, developing a novel personalised digital care ecosystem for people with Psoriatic arthritis (PsA). The session brought together a diverse group of participants from across the health innovation landscape, including: EIT and EIT Health Greece representatives European Digital Innovation Hubs – Health Hub European Network of Living Labs Digital health consultants from the Greek Ministry of Digital Governance Public and private hospitals Private health insurance companies, homecare providers, and telemedicine companies The event offered valuable opportunities for sharing perspectives, building connections, and exploring collaborative strategies for the future of healthcare innovation. IMG_4494_edited.jpg 20250602_111815.jpg IMG_4499.jpg IMG_4494_edited.jpg 1/4 PREVIOUS NEXT

< BACK User Research and Co-Creation Aug 4, 2023 User Research and Co-Creation are at the core of iPROLEPSIS research process Within iPROLEPSIS , several Digital Health Tools (DHTs) will be developed with the aim to early detect the transition to PsA in PsO patients, to predict flares to allow for early intervention, and to generate personalised recommendations and personalised interventions that help manage the disease. The different DHTs to be developed are: miPROLEPSIS patient app; miPROLEPSIS healthcare practitioner dashboard; biAURA biaural sounds app; Personalised recommendation system; Personalised Gaming Suite (PGS). At iPROLEPSIS , User Research and Co-Creation form the foundation of the research process. Diverse qualitative and quantitative research methods have been employed, including interviews, observations, surveys, and usability testing, to gather data and refine our healthcare solutions. One key approach has been conducting 10 focus groups with Dutch, English, Portuguese, and Greek Psoriatic Arthritis (PsA) patients . Four prominent themes emerged from the focus group discussions: Disease Activity, Coping, Care Experience, Digital Biomarkers. To obtain more specific input from a broader population of PsA patients, a survey was created. The survey consisted of 5 sections dedicated to the following: Demographics & Technological Experience ; miPROLEPSIS Patient App - Content and Appearance; BiAURA App – Preferences; Personalised Serious Gaming Suite – Content and Appearance. Key highlights of the insights gained include: Creation of a Patient Experience Map . Psoriatic Arthritis (PsA) has a great impact on the life of those affected. Emotional wellbeing is highly related to the experienced disease activity fluctuating over time. The patient experience map relates the level of disease activity over time to the level of emotional wellbeing in a graph. The graph was created to empathise with our end users and indicate where our Digital Health Solutions might be able to help with improving their Emotional Wellbeing during various stages of disease. Development of User Personas . Engaging and relatable descriptions of user needs and desires, guiding user-centered design principles for our digital products. User Requirement Updates. Refinement of User Requirements for the Digital Health Tools based on focus group findings, ensuring that our tools meet the real needs of PsA patients. iPROLEPSIS is committed to advancing Psoriatic Arthritis (PsA) management through cutting-edge technology and empathetic design. News & Events iPROLEPSIS - news.png News & Events iPROLEPSIS - news.png 1/1 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search How is psoriatic arthritis treated? Self-care and lifestyle See related Handbook section PREVIOUS NEXT

< BACK Understanding Enthesitis in Psoriatic Arthritis Oct 7, 2024 iPROLEPSIS presented in the 16th Panhellenic Conference of EPEMY Aristotle University of Thessaloniki presented iPROLEPSIS in the 16th Panhellenic Conference of EPEMY held in Ioannina, Greece, from 3-6 October 2024. The presentation addressed important topics related to nesting, the role of enthesitis in Psoriatic Arthritis and Axial Spondyloarthritis, and the most appropriate treatment approaches for enthesitis and digitalis. This conference focused on inflammatory and autoimmune rheumatic, gastrointestinal, and skin diseases, as well as osteoporosis and osteoarthritis. Individual sessions covered Covid-19, cancer, neurological syndromes, and co-morbidities. The event emphasised clinically applied treatments, with interactive, cross-company tutorials and presentations of research projects from domestic centers, which were awarded for their contributions. Read more about the conference here . 1/1 PREVIOUS NEXT

< BACK AI-Driven Nutrition: Advanced Personal Dietary Recommendations through Deep Generative Models and ChatGPT Jun 25, 2024 AI Nutrition Recommendation Using a Deep Generative Model and ChatGPT A recent scientific report titled "AI Nutrition Recommendation Using a Deep Generative Model and ChatGPT," authored by Ilias Papastratis, Dimitrios Konstantinidis, Petros Daras, and Kosmas Dimitropoulos, introduces a novel approach to personalised dietary recommendations. This research was conducted as part of the iPROLEPSIS project. Abstract: In recent years, major advances in artificial intelligence (AI) have led to the development of powerful AI systems for use in the field of nutrition in order to enhance personalized dietary recommendations and improve overall health and well-being. However, the lack of guidelines from nutritional experts has raised questions on the accuracy and trustworthiness of the nutritional advice provided by such AI systems. This paper aims to address this issue by introducing a novel AI-based nutrition recommendation method that leverages the speed and explainability of a deep generative network and the use of novel sophisticated loss functions to align the network with established nutritional guidelines. The use of a variational autoencoder to robustly model the anthropometric measurements and medical condition of users in a descriptive latent space, as well as the use of an optimizer to adjust meal quantities based on users’ energy requirements enable the proposed method to generate highly accurate, nutritious and personalized weekly meal plans. Coupled with the ability of ChatGPT to provide an unparalleled pool of meals from various cuisines, the proposed method can achieve increased meal variety, accuracy and generalization capabilities. Extensive experiments on 3000 virtual user profiles and 84000 daily meal plans, as well as 1000 real profiles and 7000 daily meal plans, demonstrate the exceptional accuracy of the proposed diet recommendation method in generating weekly meal plans that are appropriate for the users in terms of energy intake and nutritional requirements, as well as the easiness with which it can be integrated into future diet recommendation systems. Read the full publication: https://www.nature.com/articles/s41598-024-65438-x AI Nutrition Recommendation Using a Deep Generative Model and ChatGPT .pdf Download PDF • 4.37MB 1/1 PREVIOUS NEXT