< BACK iPROLEPSIS at Health Data Summit 2025 Feb 12, 2025 Trustworthy AI in Digital Health iPROLEPSIS is excited to join AI-PROGNOSIS and other Horizon Europe research and innovation projects - T RUSTroke, SmartCHANGE, and STRATIFYHF - at the Health Data Summit 2025 in Brussels. Together, these projects will focus on practical approaches for building trustworthy AI-enabled digital health tools aimed at assessing disease risk and progression. During the workshop titled " Trustworthy AI in Digital Health: From Guidelines to Practice" on 19-20 March 2025, iPROLEPSIS will join experts in discussing the importance of ensuring data quality, addressing bias, and applying ethical AI principles in healthcare solutions. The workshop will cover frameworks, methods, and techniques across the AI system development lifecycle, emphasising how to build AI tools that are robust, fair, transparent, and protect privacy. Key discussion topics include: Ensuring data quality and mitigating bias in AI-driven healthcare Applying ethical AI principles throughout AI system development Balancing fairness, privacy, transparency, and robustness The session will be an opportunity for iPROLEPSIS and its partners to contribute to advancing the responsible use of AI in healthcare and discuss solutions for improving digital health tools. Event details: Health Data Summit 2025 Programme details: Summit Programme 1/1 PREVIOUS NEXT

< BACK Developing Sensorimotor Art Games for Psoriatic Arthritis using Agile Storyboarding and Game Co-Design Processes Jul 31, 2024 Innovative Sensorimotor Art Games for Psoriatic Arthritis: Agile Storyboarding and Co-Design Approaches Serious Games (SGs) have the potential to provide clinical care and enhance patients’ quality of life, while incorporating an element of entertainment. As part of the iPROLEPSIS Horizon Europe project, we introduce two Sensorimotor Art games designed as SGs to assist Psoriatic Arthritis (PsA) patients in managing their symptoms. These SGs provide a platform for self-expression and pain relief through engaging in rhythmic puzzle activities. The co-design process for the proposed Sensorimotor Art games followed an agile methodology, involving 14 experts (including clinicians, researchers, and game developers), to gather feedback on game requirements, storyboards, and mechanics. From the thematic analysis of the transcribed discussion, four main themes emerged, namely: Clinical value (Theme 1), Motor skills and adaptation (Theme 2), Creative engagement (Theme 3), and Feedback and future directions (Theme 4). Clinical value underlines the therapeutic benefits of Sensorimotor Art games for pain distraction and emotional well-being. Motor skills and adaptation focus on hand/finger use and adapting games for older patients. Creative engagement emphasizes fostering creativity, a positive environment, and goal achievement. Finally, Feedback and future directions highlight the importance of continuous feedback and occupational therapists’ involvement in coming sessions. The development of Sensorimotor Art games lays the groundwork for digital interventions to alleviate psychological distress and improve fine motor symptoms in PsA patients. At the same time, these SGs can also provide insights to healthcare providers and policymakers for developing future digital solutions tailored to PsA patients. Read the full publication: https://zenodo.org/records/13142606 Ramalho et al_DSAI_2024 .pdf Download PDF • 1.29MB 1/1 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search How is psoriatic arthritis treated? Non-pharmacological treatments See related Handbook section PREVIOUS NEXT

< BACK iPROLEPSIS at IEEE EMBC 2026 Aug 26, 2026 Representing iPROLEPSIS at an international biomedical engineering conference The 48th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2026) took place in Toronto, Canada, from 26 to 30 July 2026. The conference focused on “Engineering Sustainable and Equitable Healthcare” and brought together academics, medical professionals, and industry experts working in biomedical engineering and healthcare. iPROLEPSIS was represented at the conference by project partner PLUX. PLUX used the event to highlight current research initiatives and present its latest developments in biosignal measurement systems, wearable technology, and analytical software. The participation also provided opportunities for networking, exchange with specialists, and gathering feedback relevant to future development and research projects. iProlepsis_2_EMBS.jpeg iProlepsis_EMBS.jpeg iProlepsis_2_EMBS.jpeg 1/2 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search How is psoriatic arthritis treated? Drug treatments See related Handbook section PREVIOUS NEXT

< BACK Psoriatic Arthritis: State of the Art and Datasets Sep 8, 2026 A literature review of PsA symptoms, flare-related factors, monitoring approaches, predictive models and relevant datasets iPROLEPSIS has published an updated report on the state of the art in psoriatic arthritis (PsA) , covering disease symptoms, flare-related factors, monitoring approaches, predictive modelling and relevant datasets. The report reviews current knowledge on PsA and its heterogeneous manifestations, which can affect physical function and quality of life. It also examines factors that may be associated with disease flares and approaches for monitoring symptoms and disease activity. Fatigue, pain and stiffness are among the commonly reported symptoms of PsA. While no specific risk factors for flare are currently known, previous literature suggests that flare may be triggered by changes in mood, stress, sleep, bowel movements and environmental factors. Physical activity and motor skills may also be affected as a consequence of flare. The report reviews clinical and digital approaches for measuring PsA symptoms and related factors. These include questionnaires and clinical assessments, as well as smartphones and wearable devices for monitoring physical activity, fine motor skills, heart rate and heart rate variability. Imaging-based approaches, biological factors and data-driven predictive models are also considered. The report includes: Current knowledge on PsA symptoms and factors potentially associated with flare Clinical, digital, imaging and biological approaches for disease monitoring Use of smartphones and wearables to measure physical activity, motor skills and physiological signals Approaches to predictive modelling for PsA disease activity and progression Relevant multi-source datasets for research on PsA inflammation drivers, digital biomarkers and predictive models Evidence related to lifestyle recommendations and serious games The reviewed literature, identified datasets and predictive modelling approaches will contribute to further iPROLEPSIS research on PsA monitoring, inflammation drivers, digital biomarkers, lifestyle recommendations and serious games. Read the full report on Zenodo: https://zenodo.org/records/22655757 iPROLEPSIS_D2.4.png iPROLEPSIS_D2.4.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS digital ecosystem's architecture Oct 5, 2023 iPROLEPSIS ecosystem's architecture: a glimpse into technical progress One of the main objectives of the iPROLEPSIS project is to provide a digital health ecosystem to support healthcare professionals in disease screening, monitoring, and treatment while empowering individuals with/at risk of Psoriatic Arthritis with personalised insights and preventive interventions. In September 2023, the project’s technical partners introduced the first version of the iPROLEPSIS ecosystem architecture , including the initial technical specifications and product backlog. __________________ Amalia Ntemou from Netcompany-Intrasoft , consortium partner leading technical specification, system architecture and product backlog task within iPROLEPSIS, shares insights on the latest updates on the iPROLEPSIS ecosystem architecture. The first version of the iPROLEPSIS ecosystem's architecture and technical specifications has been defined. Can you explain the importance of this achievement in the project's development process? One of the main objectives of the iPROLEPSIS project is to provide a digital health ecosystem to support healthcare professionals in disease screening, monitoring, and treatment, while empowering individuals with/at risk of PsA with personalised insights and preventive interventions. The design of the architecture and the definition of functional and non-functional requirements are essential for the successful implementation of the iPROLEPSIS ecosystem as it constitutes a clear and comprehensive guide for partners’ development efforts. Various systems’ elements, components, connectors, processes and interactions are illustrated thereby enabling common understanding among project’s partners and adherence to common approaches and specifications that promote effective collaboration and delivery. A well-defined architecture with clear functional and non-functional requirements can be the basis for delivering sustainable solutions. What are the main components of the iPROLEPSIS digital ecosystem to be developed? The initial conceptual architecture of the iPROLEPSIS ecosystem consists of the miPROLEPSIS patient mobile app (including the embedded subcomponent/feature biAURA), the iPROLEPSIS healthcare professionals (HCP) web app , the cloud-based Data Management System , the AI-driven Lifestyle Recommendation Engine , the xAI-driven Models Engine and the Serious Games Suite . Finally, the operation of the entire system is supported by the Orchestration and Monitoring component . For whom is the iPROLEPSIS ecosystem specifically intended, and how does it cater to their unique needs? Patients are the primary users of the miPROLEPSIS patient app which is the tool for personalised disease monitoring. The miPROLEPSIS patient app operates as a tool for capturing data from sensors and wearable devices, as well as communicating feedback from the recommendation engine to the user. The miPROLEPSIS patient app incorporates additional applications/features (e.g., biAURA, keyboard etc.) for further monitoring of patients’ conditions, interventions and engagement hooks. Via the miPROLEPSIS HCP app, doctors and health care professionals are able to track their patients’ health status, review projections of the PsA progression, and utilise recommendations of optimised personalised suggestions towards a better management of PsA. Aggregated patients’ data about their health status, and outcomes of the xAI Models Engine are displayed intuitively and informatively to HCPs through dashboards. Doctors can monitor patients’ adherence to medical, dietary, and physical activity plans and issue warnings and notifications or adjust treatment regimens. In this way, accurate interventions are supported, while efficient and optimized management of PsA patients’ needs can be achieved and communicated to fellow colleagues and related stakeholders. What was the main focus while designing the iPROLEPSIS ecosystem architecture? The iPROLEPSIS digital health ecosystem serves as the enabler for personalised preventive care and the empowerment of citizens, patients and Healthcare Professionals (HCP). This emphasis on personalisation and empowerment guided the collection and definition of functional and non-functional requirements, as well as the internal architecture of components and technical specifications. Ultimately, these efforts led to the design of the ecosystem’s architecture. Have any methodologies been used in designing the iPROLEPSIS ecosystem architecture, and why is it important to use them? To organise the design and architecture of the iPROLEPSIS ecosystem, several established frameworks/methodologies were evaluated based on a thorough literature review in order to conclude to a framework that provides a holistic and comprehensive view of a software system’s architecture. Finally, we used a widely known methodology developed in 1995 by Kruchten , due to its ability to offer a structured approach to the system’s design, enabling multidisciplinary teams to represent different aspects of the system effectively and in detail. Utilising already established methodologies and following best practices, enhances efficiency, reduces risks, leads in better design decisions and contributes to overall success of the project. As the project progresses, how will the architecture and product backlog be refined and adapted during the development phases of the iPROLEPSIS? Development and establishment of the iPROLEPSIS digital health ecosystem is an ongoing process that runs approximately until the end of the project. Technical testing and verification of new versions of ecosystem’s components, as well as the monitoring of their performance and stability once released to users, have also been considered. The outcomes of development and monitoring processes will continuously populate the product backlog, representing the changing needs and priorities as the development of the components progresses. All updates and enhancements will lead to a refined version of the architecture and a fully operational iPROLEPSIS ecosystem. Stay tuned as we embark on this transformative journey towards a brighter future in Psoriatic Arthritis management! News & Events iPROLEPSIS - news.png News & Events iPROLEPSIS - news.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS Games Showcased at Lisboa Games Week 2025 Nov 24, 2025 The FMH/IST-ULisboa team presented the iPROLEPSIS Games, connecting with the gaming community and industry stakeholders The iPROLEPSIS Games were presented at Lisboa Games Week 2025 , held from 20–23 November in Portugal. The team from Faculdade de Motricidade Humana / Instituto Superior Técnico – ULisboa (Bárbara Ramalho, Samuel Gomes, Marta Vicente, Filipa Magalhães and Rodolfo Costa) showcased the serious games developed within the project. Lisboa Games Week is an event that reinforces the role of academic and professional training in the video game industry. Educational institutions present courses, projects, and programmes related to video game development, digital art, programming, design, animation, sound, virtual reality, artificial intelligence, and other technological and creative fields. The programme includes exhibitions, practical demonstrations, vocational guidance sessions, talks, and opportunities for direct contact with industry. Participation in this event provided a platform for presenting the iPROLEPSIS Games within a setting focused on education, creativity, and technological development. 🔗 https://lisboagamesweek.pt/ LGWPhoto4.jpeg LGWPhoto3.jpeg LGWPhoto3.jpeg LGWPhoto4.jpeg 1/4 PREVIOUS NEXT

< BACK User research and co-creation in iPROLEPSIS Sep 15, 2026 How patients and healthcare professionals helped shape the iPROLEPSIS Digital Care Ecosystem iPROLEPSIS has published an updated report on the user research and co-creation activities carried out to support the development of the project’s Digital Care Ecosystem for psoriatic arthritis. The report describes how patients, healthcare professionals and researchers worked together to develop, test and refine the project’s digital tools. Between July 2023 and October 2025, more than 780 patients and 30 healthcare professionals took part in activities across the Netherlands, the United Kingdom, Portugal and Greece. Participants contributed through focus groups, surveys, co-creation workshops and usability testing. Their feedback helped improve different aspects of the tools, including usability, accessibility, navigation, personalisation and visual presentation. The report covers work on the miPROLEPSIS app, the Lifestyle Recommendation System, the biAURA app, the iPROLEPSIS serious games and the dashboard for healthcare professionals. Across the different activities, participants also highlighted the importance of trust, usability and maintaining human connection when developing digital health technologies. The findings will support further refinement, multilingual testing and clinical validation of the iPROLEPSIS tools as the project moves closer to real-world implementation. Read the full report: https://zenodo.org/records/22655597 iPROLEPSIS_D2.5.png iPROLEPSIS_D2.5.png 1/1 PREVIOUS NEXT

< BACK iPROLEPSIS presented at TeraMed Conference 2026 in Angola Apr 22, 2026 The project and the iPROLEPSIS Games were presented, highlighting their relevance for digital health innovation Filipa Magalhães from Faculdade de Motricidade Humana/ Instituto Superior Técnico presented the iPROLEPSIS project and the iPROLEPSIS Games at the TeraMed Conference 2026 , held on 16 April 2026 in Angola. The conference brought together various stakeholders to discuss the challenges and opportunities of implementing digital solutions in healthcare, particularly in the Angolan context. During the event, Filipa Magalhães presented the iPROLEPSIS project and the iPROLEPSIS Games , highlighting their objectives and innovative approach. Given the limited availability of psoriatic arthritis-related data in Angola and other African countries, she emphasised the project’s potential to support the development of digital health solutions through a gamified approach , especially in regions with one of the youngest populations in the world. The co-creation methodology used in the development of the iPROLEPSIS Games was also showcased as a strong example for developers, reinforcing the importance of involving users from the early stages in order to better address real needs and increase patient engagement. As part of the event, Filipa Magalhães also gave an interview to RTP Africa, where she discussed the complexity of psoriatic arthritis and explained how this led to the creation of different game categories addressing various symptoms within the iPROLEPSIS Games. The interview also highlighted the potential impact of digital health interventions in this area. Screenshot 2026-04-21 at 12.37.49.png WhatsApp Image 2026-04-17 at 20.32.00.jpeg Screenshot 2026-04-21 at 12.37.49.png 1/2 PREVIOUS NEXT

< BACK iPROLEPSIS Project Presented to Sonova International Sep 10, 2024 Innovative Approaches in Digital Biomarkers In September 2024, the iPROLEPSIS project was presented at a meeting with Sonova International. This event included a series of insightful presentations, highlighting the project's focus on developing digital biomarkers. The iPROLEPSIS concept and vision were shared, showcasing the innovative approaches the project is undertaking. We extend our gratitude for the engaging discussions during the “Sonova-AUTH Day,” hosted by the Signal Processing & Biomedical Technology Unit at Aristotle University of Thessaloniki. The event featured a range of topics, including advancements in digital biomarkers, innovations in hearing instruments by Sonova Group, ear-EEG technology, auditory processing disorders, and insights into the hearing aid market in Greece. 1/2 PREVIOUS NEXT

Learning Hub Explore resources to help you understand and manage psoriatic arthritis. Learning hub Key Facts Handbook News Feed Quizzes Search How will psoriatic arthritis affect me? Sleep and Fatigue See related Handbook section PREVIOUS NEXT